Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

2020 ◽  
Vol 8 (17) ◽  
pp. 3939-3948 ◽  
Author(s):  
Boya Zhang ◽  
Shiyu Wan ◽  
Xinyu Peng ◽  
Mingying Zhao ◽  
Sai Li ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Tumor Ph ◽  
Tumor Retention

A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.

scholarly journals Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

2020 ◽  
Vol 14 (1) ◽  
pp. 22
Author(s):  
Kenji Tsukigawa ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
Koji Nishi ◽  
Toshihiko Tsutsumi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Coupling Reaction ◽  
Synthetic Polymer ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Polymer Conjugate ◽  
Acidic Conditions

In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Human serum albumin (HSA), which has a high biocompatibility and good biodegradability, is also a potent carrier for delivering antitumor drugs. The objective of this study was to develop pH-sensitive HSA conjugates of THP (HSA-THP), and investigate the release of THP and the cytotoxicity under acidic conditions in vitro for further clinical development. HSA-THP was synthesized by conjugating maleimide hydrazone derivatives of THP with poly-thiolated HSA using 2-iminothiolane, via a thiol-maleimide coupling reaction. We synthesized two types of HSA-THP that contained different amounts of THP (HSA-THP2 and HSA-THP4). Free THP was released from both of the HSA conjugates more rapidly at an acidic pH, and the rates of release for HSA-THP2 and HSA-THP4 were similar. Moreover, both HSA-THPs exhibited a higher cytotoxicity at acidic pH than at neutral pH, which is consistent with the effective liberation of free THP under acidic conditions. These findings suggest that these types of HSA-THPs are promising candidates for further development.

Multifunctional human serum albumin-therapeutic nucleotide conjugate with redox and pH-sensitive drug release mechanism for cancer theranostics

2017 ◽  
Vol 27 (16) ◽  
pp. 3925-3930 ◽  
Author(s):  
Vladimir A. Lisitskiy ◽  
Hamda Khan ◽  
Tatyana V. Popova ◽  
Alexey S. Chubarov ◽  
Olga D. Zakharova ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Ph Sensitive ◽  
Release Mechanism ◽  
Drug Release Mechanism ◽  
Cancer Theranostics

pH-responsive Pt-based nanoradiosensitizer for enhanced radiotherapy via oxidative stress amplification

Nanoscale ◽  
2021 ◽  
Author(s):  
Licheng Yu ◽  
Xiaolei Zhang ◽  
Xiaomin Li ◽  
Zhenjie Zhang ◽  
Xiaoyan Niu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Chloroplatinic Acid ◽  
Ph Responsive ◽  
Simple Method ◽  
Stress Amplification

Tumor radioresistance is a major issue in radiotherapy. To address it, a pH-responsive nanoradiosensitizer was synthesized employing a simple method. Initially, chloroplatinic acid was reduced by human serum albumin (HSA)...

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

2018 ◽  
Vol 133 ◽  
pp. 176-187 ◽  
Author(s):  
Claudia Tallian ◽  
Alexandra Herrero-Rollett ◽  
Karina Stadler ◽  
Robert Vielnascher ◽  
Karin Wieland ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Silk Fibroin ◽  
Ph Responsive ◽  
Self Assembling ◽  
Structural Insights

scholarly journals The pH Sensitive Atram Peptide Hitchhikes on Human Serum Albumin En Route to Target Diseased Acidic Tissues

2019 ◽  
Vol 116 (3) ◽  
pp. 513a
Author(s):  
Vanessa P. Nguyen ◽  
Stephen J. Kennel ◽  
Jonathan S. Wall ◽  
Francisco N. Barrera
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Ph Sensitive

Smart textiles in wound care: functionalization of cotton/PET blends with antimicrobial nanocapsules

2019 ◽  
Vol 7 (42) ◽  
pp. 6592-6603 ◽  
Author(s):  
Felice Quartinello ◽  
Claudia Tallian ◽  
Julia Auer ◽  
Herta Schön ◽  
Robert Vielnascher ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Silk Fibroin ◽  
Wound Care ◽  
Wound Dressings ◽  
Ph Responsive ◽  
Smart Textiles

New antimicrobial pH-responsive wound dressings consisting of immobilized human serum albumin/silk fibroin nanocapsules were developed.

II. Lokalisation der Placenta mit 113Inm- Human-Serum-Albumin

1969 ◽  
Vol 08 (01) ◽  
pp. 15-21 ◽  
Author(s):  
K. E. Scheer ◽  
J. Heep ◽  
W. Maier-Borst ◽  
W. J. Lorenz ◽  
H. Sinn ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Vena Cava ◽  
Placenta Praevia ◽  
Wird Eine

ZusammenfassungNach tierexperimentellen Voruntersuchungen wurde die Placentographie mit trägerfreiem 113Inm -HSA als klinische Methode eingeführt. Vor Amniocentesen und bei Verdacht auf Placenta praevia werden Placentographien geschrieben. Den Schwangeren wird eine Aktivität von 500 μCi in die Cubitalvene injiziert. Die der Aktivität entsprechende Indiummenge ist kleiner als 0,1 ng. Die fetale Strahlenbelastung liegt unter lOmrad. Bei Anwendung von 113Inm-HSA entfällt eine Blockade der mütterlichen und fetalen Schilddrüsen. Die genaue Abgrenzung einer Placenta praevia wird nicht durch eine Blasenaktivität beeinträchtigt.Es wurden bisher 19 Placentalokalisationen durchgeführt. In allen Fällen konnte der Placentasitz eindeutig festgestellt werden. Bedingt durch die lange Liegezeit beim Aufnehmen eines Szintigramms kam es in zwei Fällen zu einem Vena-Cava-Kompressions-Syndrom. Zur Verhinderung dieser klinischen Zwischenfälle werden inzwischen Placentographien mit der Anger-Kamera aufgenommen. Mit Hilfe des divergierenden Kollimators konnte der gesamte Abdominalbereich erfaßt werden. Die Aufnahmezeit konnte auf 7 — 10 Minuten verkürzt werden. Die intravenöse injizierte Aktivität betrug bei dieser Methode ebenfalls 500 μCi. Der diagnostische Aussagewert der Kamerabilder ist szintigraphischen Aufnahmen gleichwertig.

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