Mesoporous silica nanoparticles with bilayer coating of poly(acrylic acid-co-itaconic acid) and human serum albumin (HSA): A pH-sensitive carrier for gemcitabine delivery

2016 ◽  
Vol 61 ◽  
pp. 782-790 ◽  
Author(s):  
Ali Pourjavadi ◽  
Zahra Mazaheri Tehrani
Keyword(s):  
Human Serum Albumin ◽  
Acrylic Acid ◽  
Mesoporous Silica ◽  
Serum Albumin ◽  
Human Serum ◽  
Silica Nanoparticles ◽  
Itaconic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive ◽  
Bilayer Coating

scholarly journals Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

2020 ◽  
Vol 14 (1) ◽  
pp. 22
Author(s):  
Kenji Tsukigawa ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
Koji Nishi ◽  
Toshihiko Tsutsumi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Coupling Reaction ◽  
Synthetic Polymer ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Polymer Conjugate ◽  
Acidic Conditions

In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Human serum albumin (HSA), which has a high biocompatibility and good biodegradability, is also a potent carrier for delivering antitumor drugs. The objective of this study was to develop pH-sensitive HSA conjugates of THP (HSA-THP), and investigate the release of THP and the cytotoxicity under acidic conditions in vitro for further clinical development. HSA-THP was synthesized by conjugating maleimide hydrazone derivatives of THP with poly-thiolated HSA using 2-iminothiolane, via a thiol-maleimide coupling reaction. We synthesized two types of HSA-THP that contained different amounts of THP (HSA-THP2 and HSA-THP4). Free THP was released from both of the HSA conjugates more rapidly at an acidic pH, and the rates of release for HSA-THP2 and HSA-THP4 were similar. Moreover, both HSA-THPs exhibited a higher cytotoxicity at acidic pH than at neutral pH, which is consistent with the effective liberation of free THP under acidic conditions. These findings suggest that these types of HSA-THPs are promising candidates for further development.

P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release

2015 ◽  
Vol 26 (10) ◽  
pp. 1203-1208 ◽  
Author(s):  
Yu-Jie Chang ◽  
Xi-Zhen Liu ◽  
Qing Zhao ◽  
Xiao-Hai Yang ◽  
Ke-Min Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment

2019 ◽  
Vol 175 ◽  
pp. 477-486 ◽  
Author(s):  
Chang-Ming Liu ◽  
Guang-Bing Chen ◽  
Hui-Hong Chen ◽  
Jia-Bin Zhang ◽  
Hui-Zhang Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive
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