Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection

2020 ◽  
Vol 8 (35) ◽  
pp. 7987-7993
Author(s):  
Tetsuro Saeki ◽  
Eri Takano ◽  
Hirobumi Sunayama ◽  
Yuri Kamon ◽  
Ryo Horikawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Recognition ◽  
Functional Groups ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Cancer Biomarker ◽  
Glycoprotein P ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Novel sequential post-imprinting modifications were demonstrated on the development of multi-functionalized molecularly imprinted polymers for a biomarker glycoprotein.

Discovery and Development of OMNiMIPs: One MoNomer Molecularly Imprinted Polymers

2007 ◽  
Vol 1005 ◽  
Author(s):  
David A. Spivak ◽  
Martha Sibrian-Vazquez ◽  
Stephen Houck
Keyword(s):  
Molecular Recognition ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Functional Monomer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Element ◽  
Molecular Recognition Element ◽  
New Formulation ◽  
Separation Media

AbstractThere is enormous potential for the analytical applications of molecularly imprinted polymers (MIPs); for example, the imprinted polymer sites can function as the molecular recognition element of sensors, immunoassays, and separation media. However, difficulties with formulation variables and the need for empirical optimization have inhibited the widespread use of MIPs by the general scientific community. While investigating new crosslinkers for molecular imprinting, we have recently discovered a much simpler approach to MIP formation which utilizes a single crosslinking monomer, NOBE (N, Obismethacryloyl ethanolamine) in addition to template, solvent and initiator (shown in Scheme 1). We have given this molecular imprinting method the acronym “OMNiMIPs” which stands for one monomer molecularly imprinted polymers. This new formulation eliminates variables such as choice of functional monomer (FM) and crosslinker (XL), the ratio of functional monomer to crosslinker (FM/XL), and the ratio of functional monomer to template which normally complicates MIP design. The affects of OMNiMIP performance variables toward molecular recognition indicate significant differences between these new materials and traditional MIPs formulated with ethyleneglycol dimethacrylate (EGDMA) and methacrylic acid (MAA). These differences and the utility of OMNiMIPs will be discussed.

scholarly journals Molecular Recognition: Perspective and a New Approach

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2757
Author(s):  
W. Rudolf Seitz ◽  
Casey J. Grenier ◽  
John R. Csoros ◽  
Rongfang Yang ◽  
Tianyu Ren
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Binding Kinetics ◽  
Molecularly Imprinted ◽  
New Approach ◽  
Imprinted Polymers ◽  
High Affinity ◽  
Water Blocking ◽  
High Level

This perspective presents an overview of approaches to the preparation of molecular recognition agents for chemical sensing. These approaches include chemical synthesis, using catalysts from biological systems, partitioning, aptamers, antibodies and molecularly imprinted polymers. The latter three approaches are general in that they can be applied with a large number of analytes, both proteins and smaller molecules like drugs and hormones. Aptamers and antibodies bind analytes rapidly while molecularly imprinted polymers bind much more slowly. Most molecularly imprinted polymers, formed by polymerizing in the presence of a template, contain a high level of covalent crosslinker that causes the polymer to form a separate phase. This results in a material that is rigid with low affinity for analyte and slow binding kinetics. Our approach to templating is to use predominantly or exclusively noncovalent crosslinks. This results in soluble templated polymers that bind analyte rapidly with high affinity. The biggest challenge of this approach is that the chains are tangled when the templated polymer is dissolved in water, blocking access to binding sites.

Signaling molecularly imprinted polymers: molecular recognition-based sensing materials

2005 ◽  
Vol 5 (5) ◽  
pp. 263-275 ◽  
Author(s):  
Toshifumi Takeuchi ◽  
Takashi Mukawa ◽  
Hideyuki Shinmori
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Fluorescence signaling molecularly imprinted polymers for antibiotics prepared via site-directed post-imprinting introduction of plural fluorescent reporters within the recognition cavity

2016 ◽  
Vol 4 (44) ◽  
pp. 7138-7145 ◽  
Author(s):  
Hirobumi Sunayama ◽  
Takeo Ohta ◽  
Atsushi Kuwahara ◽  
Toshifumi Takeuchi
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Fluorescent Dyes ◽  
Specific Binding ◽  
Fluorescence Signal ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Fluorescent Reporters ◽  
Binding Event ◽  
Fluorescence Signaling

An antibiotic-imprinted cavity with two different fluorescent dyes was prepared by molecular imprinting and subsequent post-imprinting modifications (PIMs), for the readout of a specific binding event as a fluorescence signal.

A simple and benign protocol for the synthesis of deep eutectic solvents-based hydrophilic molecularly imprinted resin in water for excellent selective molecular recognition in aqueous phase

2021 ◽  
Author(s):  
Mingwei Wang ◽  
Fengxia Qiao ◽  
Hongyuan Yan
Keyword(s):  
Molecular Recognition ◽  
Organic Solvents ◽  
Aqueous Phase ◽  
Molecularly Imprinted Polymers ◽  
Deep Eutectic Solvents ◽  
Green Process ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Aqueous Environments

Molecularly imprinted polymers (MIPs) are conventionally synthesized in organic solvents, resulting in poor compatibility with water and weak molecular recognition of targets in aqueous environments; hence, developing a green process...

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