Recent progress in natural product-based inhibitor screening with enzymatic fluorescent probes

2021 ◽  
Vol 13 (15) ◽  
pp. 1778-1787
Author(s):  
Yi Chen
Keyword(s):  
Natural Product ◽  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Progress ◽  
Inhibitor Screening ◽  
Natural Inhibitor

In this mini review, small-molecule based enzymatic fluorescent probes for natural inhibitor screening has been discussed, which includes the construction and sensing mechanisms of developed probes and their applications in inhibitor screening.

scholarly journals Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

RSC Advances ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1393-1415
Author(s):  
Xingwei Chen ◽  
Zhongxi Huang ◽  
Lihua Huang ◽  
Qian Shen ◽  
Nai-Di Yang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Progress ◽  
Assembly Strategy

In this review, we comprehensively summarize the recent progress in the development of small molecular fluorescent probes based on the covalent assembly principle. The challenges and perspective in this field are also presented.

Recent progress in small molecule fluorescent probes for nitroreductase

2018 ◽  
Vol 29 (10) ◽  
pp. 1451-1455 ◽  
Author(s):  
Wenjing Qin ◽  
Chenchen Xu ◽  
Yanfei Zhao ◽  
Changmin Yu ◽  
Sheng Shen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Progress

Recent progress in two-photon small molecule fluorescent probes for enzymes

2019 ◽  
Vol 30 (10) ◽  
pp. 1738-1744 ◽  
Author(s):  
Ding Chen ◽  
Wenjing Qin ◽  
Haixiao Fang ◽  
Lan Wang ◽  
Bo Peng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Progress ◽  
Two Photon

Recent Progress Towards Synthesis of the Indolizidine Alkaloid 195B

2020 ◽  
Vol 17 (2) ◽  
pp. 82-90 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Fatemeh Mohajer ◽  
Zohreh kheilkordi
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Recent Progress ◽  
Human Life ◽  
Natural Compounds ◽  
Biologically Active ◽  
Pharmaceutical Chemistry ◽  
Biological Perspective ◽  
Highly Active

Background: Natural products have been received attention due to their importance in human life as those are biologically active. In this review, there are some reports through different methods related to the synthesis of the indolizidine 195B which was extracted from poisonous frog; however, due to respect nature, the synthesis of natural compounds such as indolizidine has been attracted much attention among scientists and researchers. Objective: This review discloses the procedures and methods to provide indolizidine 195B from 1989 to 2018 due to their importance as a natural product. Conclusion: There are several methods to give rise to the indolizidine 195B as a natural product that is highly active from the biological perspective in pharmaceutical chemistry. In summary, many protocols for the preparations of indolizidine 195B from various substrates, several reagents, and conditions have been reported from different aromatic and aliphatic.

A new method for the in situ assay of α-glucosidase activity and inhibitor screening through an enzyme substrate-mediated DNA hybridization chain reaction

2019 ◽  
Vol 43 (24) ◽  
pp. 9458-9465
Author(s):  
Xiquan Yue ◽  
Lihong Su ◽  
Xu Chen ◽  
Junfeng Liu ◽  
Longpo Zheng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Dna Hybridization ◽  
New Method ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Inhibitor Screening ◽  
Glucosidase Activity ◽  
Enzyme Substrate ◽  
In Situ Assay

The strategy is based on small molecule-mediated hybridization chain reaction.

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