Thermodynamic solubility of celecoxib in organic solvents

CrystEngComm ◽  
2022 ◽  
Author(s):  
Vivek Verma ◽  
Rodrigo Soto ◽  
Shayon Bhattacharya ◽  
Damien Thompson ◽  
Kevin Michael Ryan ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Organic Solvents ◽  
Stable Polymorph

The present work investigates the solubility of the stable polymorph of celecoxib (CEL) drug in a range of pure organic solvents, including methanol, isopropanol, butanol, ethyl acetate, acetonitrile and toluene,...

scholarly journals Toxicity of Thevetia peruviana (Pers) Schum. Extract to Adults of Callosobruchus maculatus F. (Coleoptera: Bruchidae)

1970 ◽  
pp. 105-109 ◽  
Author(s):  
JU Mollah ◽  
W Islam
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Organic Solvents ◽  
Callosobruchus Maculatus ◽  
Root Extract ◽  
Thevetia Peruviana

Leaf, stem and roots of Thevetia peruviana (Pers) Schum. were extracted in four organic solvents; petroleum spirit, ethyl acetate, acetone and methanol and tested against the adults of Callosobruchus maculatus F. All the tested extracts effectively produced mortality of C. maculatus and their toxicity was in order of solvents: petroleum spirit>ethyl acetate>acetone>methanol. Root extract was the most toxic to C. maculatus. Females were more tolerant than males. Key words: Extract, mortality, solvent, Thevetia peruviana, Callosobruchus maculatus. DOI = 10.3329/jard.v5i1.1466 J Agric Rural Dev 5(1&2), 105-109, June 2007

scholarly journals In vitro Antibacterial Activity and Phytochemical Analysis of Nicotiana tabacum L. Extracted in Different Organic Solvents

2017 ◽  
Vol 11 (1) ◽  
pp. 352-359 ◽  
Author(s):  
Gemechu Ameya ◽  
Aseer Manilal ◽  
Behailu Merdekios
Keyword(s):  
Nicotiana Tabacum ◽  
Medicinal Plants ◽  
Ethyl Acetate ◽  
Organic Solvents ◽  
Ethyl Acetate Extract ◽  
Antimicrobial Activities ◽  
Modern Medicine ◽  
Phytochemical Analysis ◽  
Human Pathogens

Background: Controlling infectious disease using medicinal plants is the oldest healthcare known to mankind. Regardless of the enormous advances observed in modern medicine, medicinal plants are still playing vital roles. However, only a small proportion of medicinal plants are examined for bioactive compounds which may vary in different factors. This study aimed to evaluate phytochemical constituent and antimicrobial activities of Nicotiana tabacum L. extracted by different solvents against three set of bacteria. Methods: Nicotiana tabacum L. was collected from the Western Ethiopia and extracted in seven organic solvents. An in-vitro anti-bacterial activity of plant extracts was carried out by agar well diffusion assay against microbial type culture collection of human pathogens, clinical bacterial isolates, and biofilm forming bacteria. Gas Chromatographic and Mass Spectroscopic (GC-MS) analysis was used to determine the phytochemical constituents. Results: Antimicrobial activities of plant extract vary by extraction solvents; and ethyl acetate based extracts showed better antimicrobial activities. Of the experimental organisms, biofilm forming uropathogens were the most sensitive while clinical isolates were quite resistant. Analysis of the active ethyl acetate extract by GC-MS evinced a mixture of five volatile compounds; and Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S) was the major compound detected. The overall results of the present study revealed that N. tabacum L extract has high antimicrobial activities against biofilm forming uropathogens. Conclusion: High antimicrobial activity was observed in ethyl acetate extract of N. tabacum against the biofilm forming bacteria whereas the clinically isolated bacteria were the most resistant group. The antibacterial property demonstrated could be due to Pyridine, 3-(1-methyl-2-pyrrolidinyl)-(S) with a broad spectrum of activity.

In vitro screening of inhibition of PPAR-γ activity as a first step in identification of potential breast carcinogens

2015 ◽  
Vol 34 (11) ◽  
pp. 1106-1118 ◽  
Author(s):  
TI Kopp ◽  
J Lundqvist ◽  
RK Petersen ◽  
A Oskarsson ◽  
K Kristiansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Ethyl Acetate ◽  
Organic Solvents ◽  
Inhibitory Effect ◽  
Aromatase Activity ◽  
Peroxisome Proliferator ◽  
Dependent Manner ◽  
Screening Assay ◽  
Ppar Γ

Alcohol consumption and increased estrogen levels are major risk factors for breast cancer, and peroxisome proliferator-activated receptor γ (PPAR-γ) plays an important role in alcohol-induced breast cancer. PPAR-γ activity is inhibited by ethanol, leading to increased aromatase activity and estrogen biosynthesis ultimately leading to breast cancer. If other organic solvents inhibit PPAR-γ activity, they should also lead to increased oestrogen biosynthesis and thus be potential breast carcinogens. Ten commonly used hydrophilic organic solvents were first tested in a cell-based screening assay for inhibitory effects on PPAR-γ transactivation. The chemicals shown to inhibit PPAR-γ were tested with vectors encoding PPAR-γ with deleted AB domains and only the ligand-binding domain to rule out unspecific toxicity. Next, the effects on biosynthesis of estradiol, testosterone and oestrone sulphate were measured in the H295R steroidogenesis assay after incubation with the chemicals. Ethylene glycol, ethyl acetate, and dimethyl sulphoxide inhibited PPAR-γ transactivation in a dose-dependent manner. The inhibitory effect on PPAR-γ was specific for PPAR-γ since the AB domain of PPAR-γ was required for the inhibitory effect. In the second step, ethylene glycol significantly increased production of oestradiol by 19% ( p < 0.05) and ethyl acetate inhibited production of testosterone ( p < 0.05). We here show that screening of 10 commonly used organic solvents for the ability to inhibit PPAR-γ transactivation followed by a well-established steroidogenesis assay for production of sex hormones in exposed H295 R cells may provide a screening tool for potential breast carcinogens. This initial screening thus identified ethylene glycol and possibly ethyl acetate as potential breast carcinogens.

scholarly journals Fractionation of lignin produced from the Earleaf Acacia tree by sequential industrial organic solvents

2021 ◽  
Vol 24 (1) ◽  
pp. 1835-1841
Author(s):  
Thong Hoang Le ◽  
Khanh B. Vu ◽  
Quynh-Thy Song Nguyen ◽  
Phat Van Huynh ◽  
Khanh-Ly T. Huynh ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Organic Solvent ◽  
Ethyl Acetate ◽  
Organic Solvents ◽  
Weight Fraction ◽  
Ft Ir ◽  
Catalytic Applications ◽  
Light Medium ◽  
Acacia Tree ◽  
Different Molecular Weight

Introduction: Understanding the fractions of lignin is important for further conversion of lignin into valuable products. Herein, the “home-made” lignin from Earleaf Acacia tree was extracted by sequential industrial organic solvent and characterized each fraction to reveal its properties for further catalytic applications. Methods: In this work, lignin was prepared from the Earleaf Acacia tree using the soda method. Then, the prepared lignin was fractionated by sequential solvents of ethyl acetate, ethanol, methanol, and acetone. Each lignin fractions were characterized by FT-IR and GPC. Results: The FT-IR results confirmed the soda method can produce lignin from woodchips. The fractionation of lignin separated the lignin mixture into different molecular weight fraction from light – medium into heavy compounds. Conclusion: Lignin was produced from woodchips using the soda method successfully. The fractionation using the sequential organic solvents showed the separation of different molecular weight of lignin, which allow to apply for the further conversion into useful products.

Synthesis, Characterization of 2',7'-dibromo-2,3,6,7-tetraethoxy-9,9'-spirobifluorene

2013 ◽  
Vol 781-784 ◽  
pp. 499-502
Author(s):  
Chun Hua Qi ◽  
Xiao Long Lei ◽  
Xiao Xia Sun ◽  
Yu Hu
Keyword(s):  
Ethyl Acetate ◽  
Organic Solvents ◽  
Methylene Chloride ◽  
Good Solubility ◽  
Synthetic Procedure ◽  
High Yields

A simple and efficient synthetic procedure of 2',7'-dibromo-2,3,6,7-tetraethoxy-9,9'-spirobi [fluoren has been developed. The new monomer of 2',7'-dibromo-2,3,6,7-tetraethoxy-9,9'-spirobi [fluoren has been synthesized in high yields over five steps from readily available starting materials. The new monomer has good solubility in organic solvents such as chloroform, methylene chloride, tetrahydrofuran, ethyl acetate and so on.

The ease estimating of occupational inhalation exposure to three organic solvents: Toluene, ethyl acetate and acetone

2010 ◽  
Vol 196 ◽  
pp. S69-S70
Author(s):  
S. Czerczak ◽  
M. Kupczewska Dobecka
Keyword(s):  
Ethyl Acetate ◽  
Organic Solvents ◽  
Inhalation Exposure

Organic Solvents for Separating Ethyl Acetate-Ethanol by Extractive Distillation

2012 ◽  
Vol 550-553 ◽  
pp. 699-703
Author(s):  
Zhi Gang Zhang ◽  
Ming Lv ◽  
Li Feng Chen ◽  
Wen Xiu Li
Keyword(s):  
Ethyl Acetate ◽  
Organic Solvents ◽  
Mixed Solvent ◽  
Extractive Distillation ◽  
Measured Data ◽  
Azeotropic Mixture ◽  
Distillation Process ◽  
Influence Of Temperature ◽  
Unifac Model ◽  
Influence Of Temperature On

The azeotropic mixture ethyl acetate-ethanol (EA-EtOH) enables effective separation by extractive distillation. The effectiveness of an extractive distillation process depends on the solvent selection, so the single and mixed solvent for separating ethyl acetate-ethanol by extractive distillation were examined. The results showed that the volatility of the ethyl acetate relative to ethanol increased with an increase of the ratio of any given solvent. The selectivity of the mixed solvent is superior to the single solvent. The measured data were correlated well using modified UNIFAC model. Simultaneously, the influence of temperature on solvent selectivity was proposed by using the Clausius-Mosotti equation.

Analytical voltammetry in low-permitivity organic solvents using disk and cylindrical microelectrodes. Determination of thiram in ethyl acetate

2000 ◽  
Vol 46 (2-3) ◽  
pp. 289-296 ◽  
Author(s):  
M.A Hernández-Olmos ◽  
L Agüı́ ◽  
P Yáñez-Sedeño ◽  
J.M Pingarrón
Keyword(s):  
Ethyl Acetate ◽  
Organic Solvents

Enthalpies of solution of naphthalene, N,N-dimethyl-1-naphthylamine, and 1,8-bis(dimethylamino)naphthalene in 16 organic solvents

1992 ◽  
Vol 70 (6) ◽  
pp. 1586-1589 ◽  
Author(s):  
Daniel Figeys ◽  
Maegorzata Koschmidder ◽  
Robert L. Benoit
Keyword(s):  
Carbon Tetrachloride ◽  
Ethyl Acetate ◽  
Dimethyl Sulfoxide ◽  
Organic Solvents ◽  
Enthalpies Of Solution ◽  
Proton Sponge ◽  
Solvent Interactions ◽  
Linear Relationships

The enthalpies of solution of naphthalene, N,N-dimethyl-1-naphthylamine, and 1,8-bis(dimethylamino)naphthalene (proton sponge) were determined at 298.15 K in 16 organic solvents (n-hexane, cyclohexane, carbon tetrachloride, chloroform, 1,2-dichloroethane, benzene, chlorobenzene, dimethyl sulfoxide, N,N-dimethylformamide, ethyl acetate, 1,4-dioxane, anisole, nitrobenzene, benzonitrile, methanol, ethanol). Additional determinations were made with benzene. Useful linear relationships are observed between the molar enthalpies of solution of the four compounds in the solvents. The molar enthalpies of solution were correlated with the solvatochromic parameter of the solvents. The presence of N(CH3)2 groups on naphthalene does not significantly contribute to the solute–solvent interactions.

Enthalpies and Heat Capacities of Ethyl Acetate Solutions in Water and in Several Organic Solvents at 298–318 K

2012 ◽  
Vol 41 (6) ◽  
pp. 1008-1012 ◽  
Author(s):  
Andrey V. Kustov ◽  
Nataliya L. Smirnova ◽  
Olga A. Antonova
Keyword(s):  
Ethyl Acetate ◽  
Organic Solvents ◽  
Heat Capacities
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