A novel anti-inflammatory activity of mcIRBP from Momordica charantia is associated with the improvement of diabetic nephropathy

2022 ◽  
Author(s):  
Pei-Yung Liao ◽  
Hsin-Yi Lo ◽  
I-Chen Liu ◽  
Lun-Chien Lo ◽  
Chien-Yun Hsiang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Amino Acid ◽  
Insulin Receptor ◽  
Amino Acid Residue ◽  
Trypsin Inhibitor ◽  
Momordica Charantia ◽  
Inflammatory Activity ◽  
Immune Disorder ◽  
Anti Inflammatory

Diabetic nephropathy is an inflammatory immune disorder accompanying diabetes. mcIRBP, the trypsin inhibitor of Momordica charantia, is an abundant 68-amino-acid-residue protein that interacts with the insulin receptor. Here the long-term...

A gastro-resistant peptide from Momordica charantia improves diabetic nephropathy in db/db mice via its novel reno-protective and anti-inflammatory activities

2022 ◽  
Author(s):  
Pei-Yung Liao ◽  
Hsin-Yi Lo ◽  
I-Chen Liu ◽  
Lun-Chien Lo ◽  
Chien-Yun Hsiang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Glucose Homeostasis ◽  
Momordica Charantia ◽  
Microvascular Complication ◽  
Immune Disorder ◽  
Blood Glucose Homeostasis ◽  
Anti Inflammatory

Diabetic nephropathy (DN), a principal diabetic microvascular complication, is a chronic inflammatory immune disorder. A gastro-resistant peptide mcIRBP-9 from Momordica charantia has shown the modulation of blood glucose homeostasis in...

Abstract 212: Prophylactic Anti-inflammatory Treatment Attenuates The Neuroinflammatory And Behavioral Effects Of Silent Cerebral Infarction

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Christina L Nemeth ◽  
Gretchen N Neigh
Keyword(s):  
Gene Expression ◽  
Cardiac Surgery ◽  
Open Field ◽  
Treatment Strategies ◽  
Fold Change ◽  
Inflammatory Activity ◽  
Central Tendency ◽  
Negative Consequences ◽  
Anti Inflammatory

Silent brain infarction is a frequent complication of cardiac surgery and is associated with mood changes and cognitive disruption. Microsphere embolism (ME) rodent models recapitulate both the diffuse ischemic infarcts and the delayed subtle behavioral disturbances characteristic to silent infarction (SI). Previously, we have shown that ME leads to increased hippocampal inflammation, weakening of the blood brain barrier, and the infiltration of peripherally circulating inflammatory cells in rats. Given long-term increases in inflammatory activity following SI, the current study tests the efficacy of anti-inflammatory versus anti-depressant treatment strategies to reduce the inflammatory and behavioral sequelae of injury. Adult rats were administered either chronic meloxicam (preferential COX-2 inhibitor) or fluoxetine (SSRI) beginning five days prior to ME surgeries. After a two week recovery, animals were tested for anxiety-like behaviors in the open field paradigm and the hippocampus was examined for gene expression of inflammatory cytokines. Meloxicam treated animals showed a decrease in hippocampal gene expression of inflammatory markers (SPP1; p = 0.0272) and greater than a 3-fold change improvement in open field central tendency (p = 0.0003). No differences in inflammatory gene expression were observed in fluoxetine treated animals (SPP1; p = 0.3288); however, fluoxetine treatment resulted in a 2-fold change improvement in open field central tendency (p = 0.0138) suggesting that while both treatment strategies attenuate SI induced behavioral disruption, only meloxicam acts via inflammatory mechanisms. Given the long term negative consequences of increased central and peripheral inflammatory activity, the data suggest that anti-inflammatory therapeutic strategies may benefit patients at risk for SI as well as cardiac surgery candidates.

Antioxidant Activity of DLω-Phenyl-Amino Acid Octyl Esters with Anti-inflammatory Activity

2011 ◽  
Vol 51 (06) ◽  
pp. 485-488
Author(s):  
Christos Kontogiorgis ◽  
Dimitra Hadjipavlou-Litina ◽  
Elisabeth Schulz
Keyword(s):  
Antioxidant Activity ◽  
Amino Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Anti-nociceptive and anti-inflammatory activity of synthesized novel benzoxazole derivatives

2021 ◽  
Vol 20 ◽  
Author(s):  
Mansi L. Patil ◽  
Swati S. Gaikwad ◽  
Naresh J. Gaikwad
Keyword(s):  
Cytotoxic Activity ◽  
Research Study ◽  
Ex Vivo ◽  
Immunological Response ◽  
Inflammatory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Introduction: Pain is an immunological response to any infection or inflammation and long term use of pain management therapy includes use of Nonsteroidal anti-inflammatory drugs which is associated with occurrence of toxicity as well as gastrointestinal bleeding. Therefore, the investigation of new analgesic and anti-inflammatory agents remains a major challenge. Aims: The objective of this research study is to undergo the pharmacological evaluation of newly synthesized benzoxazole derivatives. These novel derivatives were evaluated for anti-nociceptive, anti-inflammatory and cytotoxic activity using various in-vivo and ex-vivo methods. Methods: The study was carried out using swiss mice (adult male) weighing between 20gm to 30gm and were divided into groups containing (n=6) six animals in each group for treatment. The anti-nociceptive activity was performed by using 0.1ml of 0.6% v/v acetic acid as nociception inducer and evaluated by the diminished number of abdominal writhes. The anti-inflammatory activity was done using 0.1 ml of 2% w/v Carrageenan induced paw edema method was observed which was evaluated by calculating the percent maximum possible effect. Histopathological evaluation and cytotoxic activity of the compounds was carried out. Results: The results of this research study revealed that synthesized derivatives (a, b, c, d and e) showed promising anti-nociceptive and anti-inflammatory effect along significantly higher cytotoxic activity in MCF-7 cell lines. Conclusion: It can be concluded that synthesized derivatives (a, b, c, d and e) have potential anti-nociceptive and anti-inflammatory effect along with cytotoxic activity and certain modification in structure may result in potent activity.

scholarly journals Long-Term Consumption of an Amino Acid Diet Reduces the Pancreatic Enzyme Secretion Response to a Trypsin Inhibitor in Rats

1997 ◽  
Vol 127 (7) ◽  
pp. 1377-1381 ◽  
Author(s):  
Yutaka Miura ◽  
Hidemichi Murayama ◽  
Satoshi Tsuzuki ◽  
Etsuro Sugimoto ◽  
Kunio Torii ◽  
...  
Keyword(s):  
Amino Acid ◽  
Trypsin Inhibitor ◽  
Pancreatic Enzyme ◽  
Enzyme Secretion ◽  
Acid Diet ◽  
Pancreatic Enzyme Secretion ◽  
Amino Acid Diet

scholarly journals ANTI-INFLAMMATORY EFFECTS OF LOW PROTEIN DIET SUPPLEMENTED WITH KETO-AMINO ACID IN THE TREATMENT OF TYPE 2 DIABETIC NEPHROPATHY

2012 ◽  
Vol 31 (2) ◽  
pp. A24
Author(s):  
Nan Chen ◽  
Yuanmeng Jin ◽  
Hong Ren ◽  
Jing Xu ◽  
Pingyan Shen ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Amino Acid ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Anti Inflammatory ◽  
Type 2 Diabetic
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