scholarly journals Electrochemical multicomponent synthesis of 4-selanylpyrazoles under catalyst- and chemical-oxidant-free conditions

2021 ◽  
Author(s):  
Yan Wu ◽  
Jin-Yang Chen ◽  
Jing Ning ◽  
Xue Jiang ◽  
Jie Deng ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Raw Materials ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Simple Protocol ◽  
High Yields

An electrochemical multicomponent reaction was established under catalyst-, chemical-oxidant-free and mild conditions, which provides an eco-friendly and simple protocol for constructing 4-selanylpyrazoles from easily available raw materials with high yields.

One-pot multicomponent synthesis of β-acetamidoketones catalysed by pTSA1

2007 ◽  
Vol 85 (7-8) ◽  
pp. 479-482 ◽  
Author(s):  
Biswanath Das ◽  
Kongara Ravinder Reddy ◽  
Yallamalla Srinivas ◽  
Rathod Aravind Kumar
Keyword(s):  
Multicomponent Reaction ◽  
Acetyl Chloride ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields ◽  
Three Component Coupling

A catalytic amount of pTSA has been found to be effective to carry out a one-pot three-component coupling of aromatic aldehydes, enolizable ketones or ketoesters, and acetonitrile in the presence of acetyl chloride to afford β-acetamidoketones in high yields. Short reaction times and inexpensive catalyst are main advantages of this protocol.Key words: β-acetamidoketone, pTSA, multicomponent reaction, diastereoselectivity.

scholarly journals A Green and Simple Protocol for Extraction and Application of a Peroxidase-Rich Enzymatic Extract

2020 ◽  
Vol 3 (2) ◽  
pp. 25
Author(s):  
Gonçalo P. Rosa ◽  
Maria do Carmo Barreto ◽  
Diana C. G. A. Pinto ◽  
Ana M. L. Seca
Keyword(s):  
Raw Materials ◽  
Low Cost ◽  
Environmentally Friendly ◽  
Chemical Processes ◽  
Enzymatic Extract ◽  
Renewable Raw Materials ◽  
Mild Conditions ◽  
Social Expectation ◽  
Simple Protocol ◽  
Working Parameters

Recently there is a great social expectation that scientists should produce more sustainable and environmentally friendly chemical processes. Within this necessity, biocatalysis presents many attractive features because reactions are often performed in water, under mild conditions, the catalyst is biodegradable and can be obtained from renewable raw materials. In this work, we propose a simple, rapid and low-cost method for the preparation and application of an enzymatic extract from turnip root. The protocol described includes (1) the preparation of the enzymatic extract, (2) the procedure for the assessment of the more favorable working parameters (temperature, pH) and (3) the methodology for the application of the extract as the catalyst for biotransformation reactions. We anticipate that the protocol in this research will provide a simple way for obtaining an enzymatic extract which can operate efficiently under mild conditions and can effectively catalyze the biotransformation of simple phenols.

Direct catalytic synthesis of β-(C3)-substituted pyrroles: a complementary addition to the Paal–Knorr reaction

2021 ◽  
Vol 57 (2) ◽  
pp. 251-254
Author(s):  
Amol Prakash Pawar ◽  
Jyothi Yadav ◽  
Nisar Ahmad Mir ◽  
Eldhose Iype ◽  
Krishnan Rangan ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Catalytic Synthesis ◽  
Primary Amines ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Substituted Pyrroles ◽  
High Yields

Direct catalytic multicomponent synthesis of β-(C3)-substituted pyrroles is developed with good to high yields, using aqueous succinaldehyde, primary amines, and isatins under mild conditions. An access to the β-substituted free NH-pyrrole is the main focus of the work along with DFT-calculations.

Multicomponent synthesis of new curcumin-based pyrano[2,3-d]pyrimidine derivatives using a nano-magnetic solid acid catalyst

2017 ◽  
Vol 41 (20) ◽  
pp. 12293-12302 ◽  
Author(s):  
Farhad Panahi ◽  
Esmaeil Niknam ◽  
Samira Sarikhani ◽  
Fatemeh Haghighi ◽  
Ali Khalafi-Nezhad
Keyword(s):  
Multicomponent Reaction ◽  
Solid Acid ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Efficient Synthesis ◽  
Multicomponent Synthesis ◽  
Pyrimidine Derivatives ◽  
Mild Conditions ◽  
Magnetic Solid ◽  
Magnetic Solid Acid

An novel nano-magnetic solid acid catalyst was used for the efficient synthesis of new curcumin-based pyrano[2,3-d]pyrimidine derivatives via a multicomponent reaction under mild conditions.

scholarly journals Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization

2014 ◽  
Vol 10 ◽  
pp. 209-212 ◽  
Author(s):  
Lisa Moni ◽  
Luca Banfi ◽  
Andrea Basso ◽  
Alice Brambilla ◽  
Renata Riva
Keyword(s):  
Multicomponent Reaction ◽  
Glycolic Acid ◽  
Ugi Reaction ◽  
Diversity Oriented Synthesis ◽  
Simple Protocol ◽  
High Yields

An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high yields from salicylic derivatives.

scholarly journals Nitrile Synthesis with Aldoxime Dehydratases: A Biocatalytic Platform with Applications in Asymmetric Synthesis, Bulk Chemicals, and Biorefineries

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4466
Author(s):  
Pablo Domínguez de María
Keyword(s):  
Asymmetric Synthesis ◽  
Organic Solvents ◽  
Raw Materials ◽  
Aqueous Media ◽  
Industrial Processes ◽  
Polymer Chemistry ◽  
Fine Chemicals ◽  
Mild Conditions ◽  
Bulk Chemicals ◽  
Recent Developments

Nitriles comprise a broad group of chemicals that are currently being industrially produced and used in fine chemicals and pharmaceuticals, as well as in bulk applications, polymer chemistry, solvents, etc. Aldoxime dehydratases catalyze the cyanide-free synthesis of nitriles starting from aldoximes under mild conditions, holding potential to become sustainable alternatives for industrial processes. Different aldoxime dehydratases accept a broad range of aldoximes with impressive high substrate loadings of up to >1 Kg L−1 and can efficiently catalyze the reaction in aqueous media as well as in non-aqueous systems, such as organic solvents and solvent-free (neat substrates). This paper provides an overview of the recent developments in this field with emphasis on strategies that may be of relevance for industry and sustainability. When possible, potential links to biorefineries and to the use of biogenic raw materials are discussed.

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

A facile approach for the synthesis of 1,3-di- and 1,2,3-tri-substituted indolizines

2015 ◽  
Vol 93 (5) ◽  
pp. 542-545 ◽  
Author(s):  
Jun Tan ◽  
Yiwen Yang ◽  
Jie Chen ◽  
Chunxiang Kuang
Keyword(s):  
Multicomponent Reaction ◽  
Pyridinium Salt ◽  
Quinolinium Salt ◽  
Convenient Synthesis ◽  
High Yields

A convenient synthesis of 1,3-di- and 1,2,3-tri-substituted indolizines involving the multicomponent reaction of pyridinium salt (or quinolinium salt), olefine acid, and 1,2-dichloroethane has been achieved. The process proceeds smoothly in moderate to high yields.

scholarly journals Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles

2018 ◽  
Vol 14 ◽  
pp. 2789-2798 ◽  
Author(s):  
Camila S Pires ◽  
Daniela H de Oliveira ◽  
Maria R B Pontel ◽  
Jean C Kazmierczak ◽  
Roberta Cargnelutti ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Functional Group ◽  
Diazo Compound ◽  
Molecular Iodine ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
X Ray ◽  
Dehydrogenative Coupling ◽  
Reflux Temperature

A one-pot iodine-catalyzed multicomponent reaction has been developed for the selective preparation of 5-amino-4-(arylselanyl)-1H-pyrazoles from a diverse array of benzoylacetonitriles, arylhydrazines and diaryl diselenides. The reactions were conducted in MeCN as solvent at reflux temperature under air. The methodology presents a large functional group tolerance to electron-deficient, electron-rich, and bulky substituents and gave the expected products in good to excellent yields. The synthesized 1,3-diphenyl-4-(phenylselanyl)-1H-pyrazol-5-amine was submitted to an oxidative dehydrogenative coupling to produce a diazo compound confirmed by X-ray analysis.

scholarly journals Zalacca Based Food Industry Development in Karang Asem District Bali Province

2020 ◽  
Vol 4 (1) ◽  
pp. 38-45
Author(s):  
I Gusti Bagus Udayana ◽  
Ni Made Defy Janurianti ◽  
AA Mayun Wirajaya ◽  
Made Yuliartini ◽  
Luh Kartini ◽  
...  
Keyword(s):  
Food Industry ◽  
Raw Materials ◽  
Added Value ◽  
Analysis Methodology ◽  
The People ◽  
Food And Beverage ◽  
Distribution Process ◽  
Hierarchy Analysis ◽  
The Aesthetic ◽  
High Yields

The food industry is one of the industries that is growing very rapidly throughout the world, including in Indonesia. Various types of food and beverages with an attractive appearance continue to be produced to increase the aesthetic value and attractiveness of consumers. Food and beverage production processes include the selection of raw materials, food and beverage processing, food and beverage quality testing, packaging to the food and beverage distribution process. Every process that takes place must be controlled so that the final product produced is safe and suitable for consumption by consumers. Zalacca production in Karangasem Regency is very good to be developed into the useful food industry. The development of the zalacca-based food industry can increase added value for the people and zalacca commodities. The results of the study using the Process Hierarchy Analysis methodology show that Chips, Syrups, and Extracts occupy high yields to be developed.

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