An insight into the determination of size and number concentration of silver nanoparticles in blood using single particle ICP-MS (spICP-MS): Feasibility of application to samples relevant to in vivo toxicology studies

2021 ◽  
Author(s):  
Isabel Abad-Álvaro ◽  
Diego Leite ◽  
Dorota Bartczak ◽  
Susana Cuello ◽  
Beatriz Gomez-Gomez ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Single Particle ◽  
Number Concentration ◽  
Biological Matrices ◽  
Icp Ms ◽  
Toxicological Studies ◽  
Insight Into

Toxicological studies concerning nanomaterials in complex biological matrices usually require a carefully designed workflow that involves handling, transportation and preparation of a large number of samples without affecting the nanoparticle...

scholarly journals Comparison of the suitability of alkaline or enzymatic sample pre-treatment for characterization of silver nanoparticles in human tissue by single particle ICP-MS

2018 ◽  
Vol 33 (5) ◽  
pp. 752-761 ◽  
Author(s):  
Janja Vidmar ◽  
Tina Buerki-Thurnherr ◽  
Katrin Loeschner
Keyword(s):  
Silver Nanoparticles ◽  
Size Distribution ◽  
Single Particle ◽  
Human Tissue ◽  
Number Concentration ◽  
Icp Ms ◽  
Pre Treatment

The method using enzymatic tissue treatment followed by spICP-MS is efficient for determination of mass and number concentration and size distribution of AgNPs in human placental tissues.

Determination of silver nanoparticles in cosmetics using single particle ICP-MS

2021 ◽  
Author(s):  
Věra Kantorová ◽  
Martin Loula ◽  
Antonín Kaňa ◽  
Oto Mestek
Keyword(s):  
Silver Nanoparticles ◽  
Single Particle ◽  
Icp Ms

scholarly journals Combination of single particle ICP-QMS and isotope dilution analysis for the determination of size, particle number and number size distribution of silver nanoparticles

2016 ◽  
Vol 31 (10) ◽  
pp. 2045-2052 ◽  
Author(s):  
Carina A. Sötebier ◽  
Daniel J. Kutscher ◽  
Lothar Rottmann ◽  
Norbert Jakubowski ◽  
Ulrich Panne ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Size Distribution ◽  
Isotope Dilution ◽  
Single Particle ◽  
Particle Number ◽  
Matrix Effects ◽  
Isotope Dilution Analysis ◽  
Size Particle ◽  
Icp Ms

Successful compensation of matrix effects by a combination of single particle ICP-MS and isotope dilution analysis.

scholarly journals Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study

2021 ◽  
Author(s):  
Olga Wronikowska ◽  
Maria Zykubek ◽  
Agnieszka Michalak ◽  
Anna Pankowska ◽  
Paulina Kozioł ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Interdisciplinary Approach ◽  
Nmda Antagonist ◽  
Exchange Chromatography ◽  
Resonance Spectroscopy ◽  
Monoamine Transporters ◽  
Ex Vivo Study ◽  
Insight Into

AbstractMephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone effects. In this study, we comprehensively evaluated glutamatergic involvement in rewarding effects of mephedrone using an interdisciplinary approach including (1) behavioural study on effects of memantine (non-selective NMDA antagonist) on expression of mephedrone-induced conditioned place preference (CPP) in rats; (2) evaluation of glutamate concentrations in the hippocampus of rats following 6 days of mephedrone administration, using in vivo magnetic resonance spectroscopy (MRS); and (3) determination of glutamate levels in the hippocampus of rats treated with mephedrone and subjected to MRS, using ion-exchange chromatography. In the presented research, we confirmed priorly reported mephedrone-induced rewarding effects in the CPP paradigm and showed that memantine (5 mg/kg) was able to reverse the expression of this effect. MRS study showed that subchronic mephedrone administration increased glutamate level in the hippocampus when measured in vivo 24 h (5 mg/kg, 10 mg/kg and 20 mg/kg) and 2 weeks (5 mg/kg and 20 mg/kg) after last injection. Ex vivo chromatographic analysis did not show significant changes in hippocampal glutamate concentrations; however, it showed similar results as obtained in the MRS study proving its validity. Taken together, the presented study provides new insight into glutamatergic involvement in rewarding properties of mephedrone.

Number of spikes in single particle ICP-MS time scans: from the very dilute to the highly concentrated range

2021 ◽  
Author(s):  
Pierre-Emmanuel Peyneau ◽  
Martin Guillon
Keyword(s):  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Particle Number ◽  
Number Concentration ◽  
Particle Number Concentration ◽  
Inductively Coupled ◽  
Nanoparticle Dispersions ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
The Difference

The particle number concentration (PNC) of dilute nanoparticle dispersions can be determined by single particle inductively coupled plasma-mass spectrometry (sp-ICP-MS). Virtually equal to zero for very dilute dispersions, the difference...

Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS

2012 ◽  
Vol 404 (2) ◽  
pp. 539-551 ◽  
Author(s):  
Cristina Losada ◽  
Joan J. Albertí ◽  
Javier Saurina ◽  
Sonia Sentellas
Keyword(s):  
In Vivo Metabolism ◽  
Drug Metabolites ◽  
Icp Ms

Possibilities of single particle—ICP-MS for determining/characterizing titanium dioxide and silver nanoparticles in human urine

2019 ◽  
Vol 54 ◽  
pp. 55-61 ◽  
Author(s):  
Kamala Badalova ◽  
Paloma Herbello-Hermelo ◽  
Pilar Bermejo-Barrera ◽  
Antonio Moreda-Piñeiro
Keyword(s):  
Silver Nanoparticles ◽  
Titanium Dioxide ◽  
Human Urine ◽  
Single Particle ◽  
Icp Ms
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