Introducing the metacore concept for multi-target ligand design

2021 ◽  
Author(s):  
Dagmar Stumpfe ◽  
Alexander Hoch ◽  
Jürgen Bajorath
Keyword(s):  

Metacore hierarchy. Shown are two model series of structural analogs (bottom, right) from which series cores (central layer) are isolated that yield a metacore (top left layer).

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1001
Author(s):  
Rui Huang ◽  
David C. Luther ◽  
Xianzhi Zhang ◽  
Aarohi Gupta ◽  
Samantha A. Tufts ◽  
...  

Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with ”small” organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.


ACS Catalysis ◽  
2021 ◽  
pp. 4550-4560
Author(s):  
Manfred Manßen ◽  
Danfeng Deng ◽  
Cameron H. M. Zheng ◽  
Rebecca C. DiPucchio ◽  
Dafa Chen ◽  
...  

2021 ◽  
Vol 13 (11) ◽  
pp. 13705-13713
Author(s):  
Shoma Kitamura ◽  
Motoyuki Iijima ◽  
Junichi Tatami ◽  
Tsubasa Fuke ◽  
Takashi Hinotsu ◽  
...  

2021 ◽  
Vol 11 (15) ◽  
pp. 6885
Author(s):  
Marcos D. Fernandez ◽  
José A. Ballesteros ◽  
Angel Belenguer

Empty substrate integrated coaxial line (ESICL) technology preserves the many advantages of the substrate integrated technology waveguides, such as low cost, low profile, or integration in a printed circuit board (PCB); in addition, ESICL is non-dispersive and has low radiation. To date, only two transitions have been proposed in the literature that connect the ESICL to classical planar lines such as grounded coplanar and microstrip. In both transitions, the feeding planar lines and the ESICL are built in the same substrate layer and they are based on transformed structures in the planar line, which must be in the central layer of the ESICL. These transitions also combine a lot of metallized and non-metallized parts, which increases the complexity of the manufacturing process. In this work, a new through-wire microstrip-to-ESICL transition is proposed. The feeding lines and the ESICL are implemented in different layers, so that the height of the ESICL can be independently chosen. In addition, it is a highly compact transition that does not require a transformer and can be freely rotated in its plane. This simplicity provides a high degree of versatility in the design phase, where there are only four variables that control the performance of the transition.


2021 ◽  
Vol 7 (23) ◽  
pp. eabf9402
Author(s):  
Katherine C. Elbert ◽  
William Zygmunt ◽  
Thi Vo ◽  
Corbin M. Vara ◽  
Daniel J. Rosen ◽  
...  

The use of nanocrystal (NC) building blocks to create metamaterials is a powerful approach to access emergent materials. Given the immense library of materials choices, progress in this area for anisotropic NCs is limited by the lack of co-assembly design principles. Here, we use a rational design approach to guide the co-assembly of two such anisotropic systems. We modulate the removal of geometrical incompatibilities between NCs by tuning the ligand shell, taking advantage of the lock-and-key motifs between emergent shapes of the ligand coating to subvert phase separation. Using a combination of theory, simulation, and experiments, we use our strategy to achieve co-assembly of a binary system of cubes and triangular plates and a secondary system involving two two-dimensional (2D) nanoplates. This theory-guided approach to NC assembly has the potential to direct materials choices for targeted binary co-assembly.


Author(s):  
Sophie B. Rubashkin ◽  
Wan-Yi Chu ◽  
Karen I. Goldberg
Keyword(s):  

Author(s):  
Andrea Bortolato ◽  
Francesca Deflorian ◽  
Giuseppe Deganutti ◽  
Davide Sabbadin ◽  
Stefano Moro ◽  
...  

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