Palladium mediated C-O bond activation of benzopyrone in 4-oxo-4H-chromone-3-carbaldehyde-4(N)-substituted thiosemicarbazone: Synthesis, structure, nucleic acid/albumin interaction, DNA cleavage, antioxidant and cytotoxic studies

2021 ◽  
Author(s):  
Shanmugapriya Arumugam ◽  
Kalaiarasi Giriraj ◽  
Ravi Manoharan ◽  
Hazel Anne Sparkes ◽  
Kalaivani Palaniappan ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Cleavage ◽  
Bond Activation ◽  
Square Planar ◽  
Cytotoxic Studies ◽  
Palladium Ion

Palladium ion mediated C-O activation at C2 carbon of benzopyrone moiety of 3-formylchromone-4(N)-substituted thiosemicarbazone (HL1-4) has been observed in a square planar palladium(II) complexes. All the complexes were characterised by...

C–F Bond activation at Ni(0) and simple reactions of square planar Ni(ii) fluoride complexes

2005 ◽  
pp. 3686 ◽  
Author(s):  
Suzanne Burling ◽  
Paul I. P. Elliott ◽  
Naser A. Jasim ◽  
Richard J. Lindup ◽  
Jennifer McKenna ◽  
...  
Keyword(s):  
Bond Activation ◽  
Square Planar ◽  
Fluoride Complexes

scholarly journals Anaerobic DNA cleavage in red light by dicopper(II) complexes on disulphide bond activation

2010 ◽  
Vol 122 (3) ◽  
pp. 321-333 ◽  
Author(s):  
Debojyoti Lahiri ◽  
Ritankar Majumdar ◽  
Ashis K. Patra ◽  
Akhil R. Chakravarty
Keyword(s):  
Dna Cleavage ◽  
Bond Activation ◽  
Red Light ◽  
Disulphide Bond

Oxidative coupling of cycloalkanones with 3-(pyridin-2-yl)-1,2,4-triazinone coordinated to Pd(II)

2018 ◽  
Vol 73 (8) ◽  
pp. 583-587
Author(s):  
Mustafa M. El-Abadelah ◽  
Firas F. Awwadi ◽  
Hamdallah A. Hodali ◽  
Rasha S. Rawajfeh ◽  
Monther S. Zreid ◽  
...  
Keyword(s):  
Single Crystal ◽  
Spectral Data ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
X Ray ◽  
X Ray Crystallography ◽  
Square Planar ◽  
Pd Complexes ◽  
Palladium Ion

AbstractDichloro[3-(pyridin-2-yl)-1,2,4-triazinone]Pd(II) undergoes oxidative C–C coupling reaction with cyclopentanone and cyclohexanone at 110°C to yield the respective Pd complexes, chloro[1-(4-chlorophenyl)-5-(2-hydroxycyclopent-1-enyl)-3-(pyridin-2-yl)-1,2,4-triazin-6(1H)-one]palladium(II) (3) and chloro[1-(4-chlorophenyl)-5-(2-hydroxycyclohex-1-enyl)-3-(pyridin-2-yl)-1,2,4-triazin-6(1H)-one]palladium(II) (4). The structures of both complexes are supported by spectral data and confirmed by single-crystal X-ray crystallography. The molecules 3 and 4 stack to form tunnel structures, whilst the geometry around the palladium ion is square planar.

scholarly journals Type I-E CRISPR-Cas system as an immune system in a eukaryote

2018 ◽  
Author(s):  
Devashish Rath ◽  
Lina Amlinger ◽  
Gargi Bindal ◽  
Magnus Lundgren
Keyword(s):  
Nucleic Acid ◽  
Dna Cleavage ◽  
Basic Research ◽  
Type I ◽  
Crispr Locus ◽  
Adaptive Immune ◽  
Research Platform ◽  
Adaptive Immune Systems ◽  
Cas Proteins

AbstractDefense against viruses and other mobile genetic elements (MGEs) is important in many organisms. The CRISPR-Cas systems found in bacteria and archaea constitute adaptive immune systems that acquire the ability to recognize MGEs by introducing nucleic acid samples, spacers, in the CRISPR locus. The CRISPR is transcribed and processed, and the produced CRISPR RNAs guide Cas proteins to degrade matching nucleic acid sequences. No CRISPR-Cas system is found to occur naturally in eukaryotic cells but here we demonstrate interference by type I-E CRISPR-Cas system from Escherichia coli introduced in Saccharomyces cerevisiae. The designed CRISPR arrays are properly expressed and processed in S. cerevisiae. Targeted plasmids display reduced transformation efficiency, indicative of DNA cleavage. Unlike e.g. Cas9-based systems, which can be used to inactivate MGEs in eukaryotes by introducing specific mutations, type I-E systems processively degrade the target. The type I-E system thus allows for defense without knowledge of MGE gene function. The reconstituted CRISPR-Cas system in S. cerevisiae can also function as a basic research platform for testing the role of various factors in the interference process.

Mononuclear and Trinuclear Palladium(II) Complexes of Single- and Three-Ring Benzyl- or Xylyl-Substituted Cyclam Derivatives

2005 ◽  
Vol 58 (5) ◽  
pp. 339 ◽  
Author(s):  
Ying Dong ◽  
Leonard F. Lindoy ◽  
Peter Turner
Keyword(s):  
Crystal Structures ◽  
Complex Cation ◽  
Palladium Complexes ◽  
X Ray ◽  
Square Planar ◽  
Single Ring ◽  
Palladium Ion ◽  
Selection Of

A selection of 1 : 1 (palladium/ligand) complexes of cyclam derivatives incorporating from one to three N-benzyl groups has been synthesized. Related 3 : 1 species of two symmetrically branched, tri-cyclam species incorporating 1,3,5-‘tribenzyl’ or phloroglucinol cores are also reported. The X-ray crystal structures of the palladium complexes of two isomeric forms of the N,N′-dibenzylated (single-ring) macrocycle have been determined. In each complex the palladium ion occupies the N4-plane of the respective macrocycles in a square planar arrangement, with each complex cation adopting a stable trans-III configuration.

scholarly journals Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage

2016 ◽  
Vol 64 (7) ◽  
pp. 817-823
Author(s):  
Toru Sugiyama ◽  
Keiko Kuwata ◽  
Yasutada Imamura ◽  
Yosuke Demizu ◽  
Masaaki Kurihara ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Cleavage ◽  
Peptide Nucleic Acid ◽  
Side Chain ◽  
Lysine Side Chain ◽  
Position Synthesis
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