The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress trigger hepatocyte apoptosis induced by silver nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Jiangyan Li ◽  
Xiaoru Chang ◽  
Mengting Shang ◽  
Shuyan Niu ◽  
Wenli Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Mitochondrial Fission ◽  
Target Organ ◽  
Engineered Nanoparticles ◽  
Hepatocyte Apoptosis ◽  
Main Target ◽  
Antimicrobial Nanoparticles ◽  
And Oxidative Stress

The previous studies have revealed that liver is the main target organ of deposition for the engineered nanoparticles. The hepatotoxicity of silver nanoparticles (AgNPs), the widely used antimicrobial nanoparticles, has...

scholarly journals Chenopodium murale essential oil alleviates the genotoxicity and oxidative stress of silver nanoparticles in the rat kidney

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mossad Abdel-Wahhab ◽  
Helmy Ahmed ◽  
Aziza El-Nekeety ◽  
Sekena Abdel-Aziem ◽  
Hafiza Shara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Essential Oil ◽  
Rat Kidney ◽  
Chenopodium Murale ◽  
And Oxidative Stress

scholarly journals Silver nanoparticles cause osmoregulatory impairment and oxidative stress in Caspian kutum (Rutilus kutum, Kamensky 1901)

2017 ◽  
Vol 189 (9) ◽  
Author(s):  
Fatemeh F. Masouleh ◽  
Bagher M. Amiri ◽  
Alireza Mirvaghefi ◽  
Hossein Ghafoori ◽  
Steffen S. Madsen
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
And Oxidative Stress

Ablation of toll-like receptor 4 mitigates cardiac mitochondrial dysfunction in hyperhomocysteinemia

2017 ◽  
Vol 95 (11) ◽  
pp. 1369-1375 ◽  
Author(s):  
Nevena Jeremic ◽  
Gregory J. Weber ◽  
Suresh C. Tyagi
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cell ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Fission ◽  
Cell Loss ◽  
Toll Like Receptor ◽  
Endothelial Cell Loss ◽  
Toll Like Receptor 4 ◽  
Immune Response Pathway ◽  
And Oxidative Stress

Hyperhomocysteinemia (HHcy) is a risk factor for adverse cardiovascular events; however, the mechanism for development of this disease is still unknown. Toll-like receptor 4 (TRL4) is a molecule involved in the immune response pathway and is quickly becoming a receptor of interest in the field of hypertension. In this study, we hypothesized that ablation of TLR4 mitigates cardiac mitochondrial dysfunction in a model of HHcy. Five strains of mice (C57BL/6J, CBS+/−, C3H, CBS+/−/C3H, and C3H/HeOuJ) 10–12 weeks old were utilized. We found that HHcy causes heart hypertrophy and promotes oxidative stress while mice with HHcy and inactivated TLR4 showed significant improvement in examined parameters. A dominance of endothelial cell mitochondrial fission over mitochondrial fusion in HHcy and oxidative stress was observed, which may explain the endothelial cell loss and dysfunction that contributes to inward cardiac remodeling.

Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrial fission and oxidative stress

2010 ◽  
Vol 100 (2) ◽  
pp. 155-162 ◽  
Author(s):  
S.P. Schmidt ◽  
T.J. Corydon ◽  
C.B. Pedersen ◽  
P. Bross ◽  
N. Gregersen
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Fission ◽  
Short Chain ◽  
Chain Acyl ◽  
And Oxidative Stress

scholarly journals DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress

2016 ◽  
Vol 1857 (8) ◽  
pp. 1267-1276 ◽  
Author(s):  
Björn Oettinghaus ◽  
Donato D'Alonzo ◽  
Elisa Barbieri ◽  
Lisa Michelle Restelli ◽  
Claudia Savoia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Mitochondrial Fission ◽  
And Oxidative Stress
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