Mixed-charge modification as a robust method to realize antiviral ability of gold nanoparticles in high protein environment

Nanoscale ◽  
2021 ◽  
Author(s):  
Xu Li ◽  
Yue Huang ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Gold Nanoparticles ◽  
Antiviral Drugs ◽  
High Protein ◽  
Human Beings ◽  
Robust Method ◽  
Sulfonic Group ◽  
Protein Environment

Pandemics caused by viruses have resulted in incalculable losses to human beings, which are exacerbated due to the lack of antiviral drugs. The sulfonic group modified nanomedicine has been proved...

Effect of size and protein environment on electrochemical properties of gold nanoparticles on carbon electrodes

2009 ◽  
Vol 77 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Timur I. Abdullin ◽  
Oksana V. Bondar ◽  
Irina I. Nikitina ◽  
Emil R. Bulatov ◽  
Michail V. Morozov ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Electrochemical Properties ◽  
Carbon Electrodes ◽  
Protein Environment

scholarly journals Meta-analysis of the role of zinc in coordinating absorption of mineral elements in wheat seedlings

Plant Methods ◽  
2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Xiaolong Guo ◽  
Xiangyu Ma ◽  
Jialiang Zhang ◽  
Jinghuan Zhu ◽  
Tian Lu ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Wheat Seedling ◽  
Mineral Elements ◽  
Human Beings ◽  
Wheat Cultivars ◽  
Robust Method ◽  
Wheat Seedlings ◽  
Modern Wheat ◽  
Role Of Zn

Abstract Background Zinc (Zn) is an important nutrient for human beings, which is also an essential micronutrient for crop growth. This study investigated the role of Zn in coordinating the mineral elements absorption in modern wheat (Triticum aestivum L.) cultivars with a new developed method. Results A method was developed, and showed a robust capability to simultaneously investigate seven mineral elements uptake in wheat seedling. With this method, we found low Zn supply (<  1 μM) promoted the absorption of potassium (K), magnesium (Mg) and manganese (Mn) in wheat seedling, while high Zn supply (>  1 μM) significantly inhibited the absorption of these elements. Cultivars with the green genes (Rht-B1b and Rht-D1b) showed a higher uptake capability on ammonium (NH4+), and cultivars with Rht-B1b allele can uptake more phosphors (P), K, calcium (Ca), Mn and Zn compared to cultivars with Rht-D1b. Further analysis indicated higher uptake capability of NH4+ in cultivars contained Rhts was independent of Zn. Conclusion The key role of Zn in coordinating for mineral elements absorption was identified in modern wheat cultivars, providing the reference for Zn application in wheat. Meanwhile, this study provides a robust method for quantifying the absorption of mineral elements, which may be adopted into the broadly investigations on the coordinated nutrients absorption of plant.

scholarly journals BIOSYNTHESIS OF GOLD NANOPARTICLES BY BIOSORPTION USING NEOSARTORYA UDAGAWAE: CHARACTERIZATION AND INVITRO EVALUATION

2016 ◽  
Vol 8 (11) ◽  
pp. 108 ◽  
Author(s):  
V. Jhansi Lakshmi ◽  
K. P. Kannan
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Zeta Potential ◽  
Uv Spectroscopy ◽  
Spherical Shape ◽  
Average Diameter ◽  
Chloroauric Acid ◽  
Human Beings ◽  
Tem Analysis ◽  
The Stability

Objective: The present study was aimed to investigate gold nanoparticles synthesized by fungal isolate Neosartorya udagawae and determination of their stability in biofluids to probe their aptness in drug delivery applications.Methods: In this procedure, gold nanoparticles were prepared by biosynthesis using seven days old culture of Neosartorya udagawae and aqueous chloroauric acid. After the complete reaction, the fungal biomass was subjected to UV-Vis, XRD, FT-IR Spectrum analysis, TEM, Zeta potential, SEM and EDX analysis.Results: Intra/extracellular synthesis of gold nanoparticles was confirmed by a sharp peak at 526 nm in UV spectroscopy. SEM, TEM analysis demonstrates the spherical shape of AuNPs with an average diameter of 50 nm and XRD confirm the crystalline gold nanoparticles. FTIR analysis reveals the presence of the protein shell around the gold nanoparticles. The zeta potential value of AuNPs was-36mV which confirmed the stability of nanoparticles dispersion. Gold nanoparticles have shown high stability in biofluids of Bovine Serum Albumin and Phosphate Buffer Saline at pH-5, pH-7and pH-9 which mimic the human colonic biological environment.Conclusion: The fungal synthesis of AuNPs has been experimentally demonstrated and their stability in BSA, 10% NaCl and PBS at pH-7. This might be a promising option for drug delivery applications in carcinogenic colon disorders in human beings. 

A Label-Free Colorimetric Biosensor for 17β-Estradiol Detection Using Nanoparticles Assembled by Aptamer and Cationic Polymer

2016 ◽  
Vol 69 (1) ◽  
pp. 12 ◽  
Author(s):  
Dongwei Zhang ◽  
Weilin Zhang ◽  
Jiayun Ye ◽  
Shenshan Zhan ◽  
Bing Xia ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Detection Limit ◽  
Colorimetric Detection ◽  
Cationic Polymer ◽  
Label Free ◽  
Human Beings ◽  
Remarkable Change ◽  
Environment Effects ◽  
Diallyldimethylammonium Chloride ◽  
17Β Estradiol

Concern is mounting regarding the human health and environment effects of 17β-estradiol (E2), a natural oestrogen excreted by human beings and animals. In this paper, a sensitive and selective biosensor for the detection of E2 using gold nanoparticles (AuNPs), label-free E2-specific aptamer, and poly(diallyldimethylammonium chloride) (PDDA) was developed. In the absence of E2, PDDA can electrostatically interact with E2-specific aptamer, and the charge responsible for inducing AuNPs aggregation was destroyed. However, the introduction of E2 can specifically interact with the aptamer to form E2–aptamer complex so that PDDA can aggregate AuNPs and cause a remarkable change in colour from wine red to blue, which enables colorimetric detection of E2 with selectivity and a detection limit of 1.57 nM.

Rate of Absorption of Water from Stomach and Small Bowel of Human Beings

1954 ◽  
Vol 27 (5) ◽  
pp. 565-577 ◽  
Author(s):  
John F. Scholer ◽  
Charles F. Code
Keyword(s):  
Small Bowel ◽  
Human Beings ◽  
Rate Of Absorption

A Study of the Action of Prostigmine on the Bowel of Human Beings

1949 ◽  
Vol 12 (6) ◽  
pp. 970-977 ◽  
Author(s):  
John M. McMahon ◽  
Charles F. Code ◽  
Willtam G. Saver ◽  
J. Arnold Bargen
Keyword(s):  
Human Beings

Constructing and Deconstructing Concepts

2016 ◽  
Vol 63 (5) ◽  
pp. 249-262 ◽  
Author(s):  
Charles A. Doan ◽  
Ronaldo Vigo
Keyword(s):  
Information Theory ◽  
Model Performance ◽  
Unsupervised Classification ◽  
Family Resemblance ◽  
Category Membership ◽  
Formal Models ◽  
Human Beings ◽  
One Dimensional ◽  
Relational Patterns ◽  
Optimal Classification

Abstract. Several empirical investigations have explored whether observers prefer to sort sets of multidimensional stimuli into groups by employing one-dimensional or family-resemblance strategies. Although one-dimensional sorting strategies have been the prevalent finding for these unsupervised classification paradigms, several researchers have provided evidence that the choice of strategy may depend on the particular demands of the task. To account for this disparity, we propose that observers extract relational patterns from stimulus sets that facilitate the development of optimal classification strategies for relegating category membership. We conducted a novel constrained categorization experiment to empirically test this hypothesis by instructing participants to either add or remove objects from presented categorical stimuli. We employed generalized representational information theory (GRIT; Vigo, 2011b , 2013a , 2014 ) and its associated formal models to predict and explain how human beings chose to modify these categorical stimuli. Additionally, we compared model performance to predictions made by a leading prototypicality measure in the literature.

Behavioral Testing of Mice Concerning Anxiety and Depression

2015 ◽  
Vol 223 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Nina Schweinfurth ◽  
Undine E. Lang
Keyword(s):  
Environmental Influences ◽  
Sickness Behavior ◽  
Laboratory Research ◽  
Anxiety And Depression ◽  
Housing Conditions ◽  
Human Beings ◽  
Behavioral Testing ◽  
New Developments ◽  
Animal Trials ◽  
Resilience Factors

Abstract. In the development of new psychiatric drugs and the exploration of their efficacy, behavioral testing in mice has always shown to be an inevitable procedure. By studying the behavior of mice, diverse pathophysiological processes leading to depression, anxiety, and sickness behavior have been revealed. Moreover, laboratory research in animals increased at least the knowledge about the involvement of a multitude of genes in anxiety and depression. However, multiple new possibilities to study human behavior have been developed recently and improved and enable a direct acquisition of human epigenetic, imaging, and neurotransmission data on psychiatric pathologies. In human beings, the high influence of environmental and resilience factors gained scientific importance during the last years as the search for key genes in the development of affective and anxiety disorders has not been successful. However, environmental influences in human beings themselves might be better understood and controllable than in mice, where environmental influences might be as complex and subtle. The increasing possibilities in clinical research and the knowledge about the complexity of environmental influences and interferences in animal trials, which had been underestimated yet, question more and more to what extent findings from laboratory animal research translate to human conditions. However, new developments in behavioral testing of mice involve the animals’ welfare and show that housing conditions of laboratory mice can be markedly improved without affecting the standardization of results.

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