scholarly journals Noninvasive Near-Infrared Light Triggers Remote Activation of Thermo-Responsive TRPV1 Channels in Neurons Based on Biodegradable/Photothermal Polymer Micelles

Nanoscale ◽  
2022 ◽  
Author(s):  
Wei-Hsu Chen ◽  
Taiki Onoe ◽  
Masao Kamimura
Keyword(s):  
Ion Channel ◽  
Near Infrared ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channel ◽  
Infrared Light ◽  
Temperature Sensitive ◽  
Polymer Micelle ◽  
Trpv1 Channels ◽  
Transient Receptor

In this study, we developed a novel biodegradable/photothermal polymer micelle-based remote-activation method for a temperature-sensitive ion channel, namely transient receptor potential cation channel subfamily V member 1 (TRPV1). Biodegradable/photothermal polymer...

scholarly journals Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Katie Baker ◽  
Kristof Raemdonck ◽  
Bilel Dekkak ◽  
Robert J. Snelgrove ◽  
John Ford ◽  
...  
Keyword(s):  
Ion Channel ◽  
Allergic Asthma ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channel ◽  
Transient Receptor

scholarly journals Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin

2015 ◽  
Vol 113 (2) ◽  
pp. E137-E145 ◽  
Author(s):  
Khaled Elokely ◽  
Phanindra Velisetty ◽  
Lucie Delemotte ◽  
Eugene Palovcak ◽  
Michael L. Klein ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Binding Mode ◽  
Cation Channel ◽  
Binding Modes ◽  
Trpv1 Channels ◽  
Density Maps ◽  
Vanilloid Receptor 1 ◽  
Ligand Interactions ◽  
Transient Receptor

The transient receptor potential cation channel subfamily V member 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the detection and transduction of nociceptive stimuli. Inflammation and nerve damage result in the up-regulation of TRPV1 transcription, and, therefore, modulators of TRPV1 channels are potentially useful in the treatment of inflammatory and neuropathic pain. Understanding the binding modes of known ligands would significantly contribute to the success of TRPV1 modulator drug design programs. The recent cryo-electron microscopy structure of TRPV1 only provides a coarse characterization of the location of capsaicin (CAPS) and resiniferatoxin (RTX). Herein, we use the information contained in the experimental electron density maps to accurately determine the binding mode of CAPS and RTX and experimentally validate the computational results by mutagenesis. On the basis of these results, we perform a detailed analysis of TRPV1–ligand interactions, characterizing the protein ligand contacts and the role of individual water molecules. Importantly, our results provide a rational explanation and suggestion of TRPV1 ligand modifications that should improve binding affinity.

Restoring light sensitivity using tunable near-infrared sensors

Science ◽  
2020 ◽  
Vol 368 (6495) ◽  
pp. 1108-1113 ◽  
Author(s):  
Dasha Nelidova ◽  
Rei K. Morikawa ◽  
Cameron S. Cowan ◽  
Zoltan Raics ◽  
David Goldblum ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Cortical Neurons ◽  
Near Infrared ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Light Sensitivity ◽  
Infrared Light ◽  
Temperature Sensitive ◽  
Near Infrared Light

Enabling near-infrared light sensitivity in a blind human retina may supplement or restore visual function in patients with regional retinal degeneration. We induced near-infrared light sensitivity using gold nanorods bound to temperature-sensitive engineered transient receptor potential (TRP) channels. We expressed mammalian or snake TRP channels in light-insensitive retinal cones in a mouse model of retinal degeneration. Near-infrared stimulation increased activity in cones, ganglion cell layer neurons, and cortical neurons, and enabled mice to perform a learned light-driven behavior. We tuned responses to different wavelengths, by using nanorods of different lengths, and to different radiant powers, by using engineered channels with different temperature thresholds. We targeted TRP channels to human retinas, which allowed the postmortem activation of different cell types by near-infrared light.

scholarly journals Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1

2021 ◽  
Vol 22 (7) ◽  
pp. 3360
Author(s):  
Mee-Ra Rhyu ◽  
Yiseul Kim ◽  
Vijay Lyall
Keyword(s):  
Transient Receptor Potential ◽  
Taste Receptor ◽  
Sensory Nerve ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Trpv1 Channels ◽  
Trigeminal Neurons ◽  
Calcitonin Gene ◽  
Transient Receptor

In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expressed in sensory nerve endings. TRPA1 and TRPV1 can also indirectly influence some, but not all, primary taste qualities via the release of substance P and calcitonin gene-related peptide (CGRP) from trigeminal neurons and their subsequent effects on CGRP receptor expressed in Type III taste receptor cells. Here, we will review the effect of some chemesthetic agonists of TRPA1 and TRPV1 and their influence on bitter, sour, and salt taste qualities.

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