Efficient synthesis of α,β-dichlorinated ketone from α,β-dichlorinated Weinreb amide through simple work-up procedure

2021 ◽  
Author(s):  
Nurcahyo I. Prakoso ◽  
Fuyuhiko Matsuda ◽  
Taiki Umezawa
Keyword(s):  
Side Reactions ◽  
Efficient Synthesis ◽  
Weinreb Amides ◽  
Weinreb Amide ◽  
Work Up

An efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides is described. Quenching with nonaqueous HCl avoided side reactions associated with the typical a work-up procedure. The amide accepted various...

An Efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling

RSC Advances ◽  
2014 ◽  
Vol 4 (57) ◽  
pp. 30019-30027 ◽  
Author(s):  
Tuan Thanh Dang ◽  
Anqi Chen ◽  
Abdul Majeed Seayad
Keyword(s):  
Palladium Nanoparticles ◽  
Recyclable Catalyst ◽  
Efficient Synthesis ◽  
Weinreb Amides ◽  
Weinreb Amide

Palladium nanoparticles on ZIF-8 as a robust and recyclable catalyst for Weinreb amide and ketone synthesis through carbonylative coupling.

scholarly journals Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives

2019 ◽  
Vol 10 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Fatma Ahmed Abo Elsoud ◽  
Mohamed Abd-Elmonem ◽  
Mohamed Abo Elsebaa ◽  
Kamal Usef Sadek
Keyword(s):  
Kojic Acid ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Short Reaction Time ◽  
Biologically Relevant ◽  
Three Component Reaction ◽  
High Yields ◽  
Organometallic Catalyst ◽  
Work Up

Efficient synthesis of non-annulated 2-amino-4H-pyrans and 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives, which are biologically relevant heterocycles is achieved, utilizing a domino three-component reaction of ethyl acetoacetate or kojic acid with aromatic aldehydes and malononitrile catalyzed by Zn(L-proline)2 as reusable organometallic catalyst. The process exhibits high atom economy, short reaction time, simple work up, high yields and environmentally friendly nature. Excellent yields of the targeted molecules have been obtained.

scholarly journals BAKERS YEAST CATALYZED AND ULTRASOUND ACCELERATED SYNTHESIS OF 2-AMINO-2-CHROMENES

2021 ◽  
Vol 9 (01) ◽  
pp. 189-195
Author(s):  
Balaji S. Londhe ◽  
◽  
Santosh L. Khillare ◽  
Avinash M. Nalawade ◽  
Ramrao A. Mane ◽  
...  
Keyword(s):  
Dual Role ◽  
Yeast Cells ◽  
Side Reactions ◽  
Efficient Synthesis ◽  
Neutral Conditions

In the present work, bakers yeast catalyzed efficient synthesis of 2-amino-2-chromenes in methanol is presented. Here the ultrasonication has dual role i.e. as a source of energy for the reaction and tool for the disruption of the yeast cells. The cyclocondensation has been essentially carried under neutral conditions, thus reducing the possibility of unwanted side reactions.

Efficient synthesis of N-protected amino/peptide Weinreb amides from T3P and DBU

2013 ◽  
Vol 54 (6) ◽  
pp. 478-482 ◽  
Author(s):  
K.M. Sharnabai ◽  
G. Nagendra ◽  
T.M. Vishwanatha ◽  
Vommina V. Sureshbabu
Keyword(s):  
Efficient Synthesis ◽  
Weinreb Amides

Diastereoselective Synthesis of Functionalised Trans-Tetrahydrobenzofuran-4-Ones in an Aqueous Medium by using DABCO as an Efficient Catalyst

2017 ◽  
Vol 41 (11) ◽  
pp. 657-660 ◽  
Author(s):  
Mohammad Reza Salari ◽  
Mohammad H. Mosslemin ◽  
Alireza Hassanabadi
Keyword(s):  
Aqueous Medium ◽  
High Purity ◽  
Reaction Times ◽  
Diastereoselective Synthesis ◽  
Efficient Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Pyridinium Bromide ◽  
Work Up

A one-pot, efficient synthesis of 11 novel 2,3-diacylated trans-tetrahydrobenzofuran-4-one derivatives has been achieved via a three-component condensation of a N-(4-halophenacyl)-pyridinium bromide, a cyclic 1,3-diketone such as 5,5-dimethyl-1,3-cyclohexanedione (dimedone) or cyclohexane-1,3-dione and an arylglyoxal in the presence of catalytic amounts of 1,4-diaza-bicyclo[2.2.2]octane (DABCO) in water under reflux conditions. The attractive features of the method are excellent yields and high purity, short reaction times, easy work-up, and use of an inexpensive and non-toxic catalyst.

scholarly journals A Solvent-Free Protocol for the Green Synthesis of 5-Arylidene-2,4-thiazolidinediones Using Ethylenediamine Diacetate as Catalyst

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yuliang Zhang ◽  
Zhongqiang Zhou
Keyword(s):  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Work Up ◽  
Solvent Free Reaction

A simple and efficient synthesis of 5-arylidene-2,4-thiazolidinediones by the Knoevenagel condensation of aromatic aldehydes with 2,4-thiazolidinedione catalyzed by ethylenediamine diacetate under solvent-free conditions is described. The major advantages of this method are simple experimental and work-up procedures, solvent-free reaction conditions, small amount of catalyst, short reaction time, high yields, and utilization of an inexpensive and reusable catalyst.

ChemInform Abstract: An Efficient Synthesis of 4-Isochromanones via Parham-Type Cyclization with Weinreb Amide.

ChemInform ◽  
2016 ◽  
Vol 47 (5) ◽  
pp. no-no
Author(s):  
Chaolei Wang ◽  
Zheng Wu ◽  
Jia Wang ◽  
Jie Liu ◽  
Hequan Yao ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Weinreb Amide

scholarly journals An Efficient Synthesis of 1,8-Dioxo-Octahydroxanthenes Derivatives Using Heterogeneous Ce-ZSM-11 Zeolite Catalyst

2018 ◽  
Vol 13 (3) ◽  
pp. 436 ◽  
Author(s):  
Rameshwar R. Magar ◽  
Ganesh T. Pawar ◽  
Sachin P. Gadekar ◽  
Machhindra Karbhari Lande
Keyword(s):  
Zeolite Catalyst ◽  
Bet Surface Area ◽  
High Yield ◽  
Efficient Synthesis ◽  
X Ray Diffraction ◽  
One Pot ◽  
Efficient Catalyst ◽  
Temperature Programmed ◽  
The One ◽  
Work Up

The Ce-ZSM-11 zeolite has been used as an efficient catalyst for the one pot synthesis of 1,8-dioxo-octahydroxanthene derivatives from aromatic aldehyde and 5,5-dimethyl-cyclohexane-1,3-dione under reflux condition. The catalyst was characterized by Powder X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), Fourier Transform Infrared Spectroscopy (FTIR), Brunauer-Emmer-Teller (BET) surface area analysis, and Temperature Programmed Desorption (TPD) techniques. This method provides several advantageous such as use of inexpensive catalyst, simple work-up procedure, high yield of desired product and reusability of catalyst. Copyright © 2018 BCREC Group. All rights reservedReceived: 5th January 2018; Revised: 25th May 2018; Accepted: 27th May 2018How to Cite: Magar, R.R., Pawar, G.T., Gadekar, S.P., Lande, M.K. (2018). An Efficient Synthesis of  1,8-Dioxo-Octahydroxanthenes Derivatives Using Heterogeneous Ce-ZSM-11 Zeolite Catalyst. Bulletin of Chemical Reaction Engineering & Catalysis, 13 (3): 436-446 (doi:10.9767/bcrec.13.3.2062.436-446)Permalink/DOI: https://doi.org/10.9767/bcrec.13.3.2062.436-446 

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