scholarly journals Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

RSC Advances ◽  
2021 ◽  
Vol 11 (28) ◽  
pp. 17301-17319
Author(s):  
Nadezda Pankratova ◽  
Milica Jović ◽  
Marc E. Pfeifer
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Critical Review ◽  
Point Of Care ◽  
Electrochemical Sensing ◽  
Blood Proteins ◽  
Protein Biomarkers

Critical review on the electrochemical (EC) protocols suggested in the literature for the quantification of protein biomarkers relevant to mild traumatic brain injury (mTBI).

scholarly journals Characteristics of patients included and enrolled in studies on the prognostic value of serum biomarkers for prediction of postconcussion symptoms following a mild traumatic brain injury: a systematic review

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017848 ◽  
Author(s):  
Eric Mercier ◽  
Pier-Alexandre Tardif ◽  
Marcel Emond ◽  
Marie-Christine Ouellet ◽  
Élaine de Guise ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Mild Traumatic Brain Injury ◽  
Prognostic Value ◽  
Protein Biomarkers ◽  
Exclusion Criteria ◽  
Evaluation Approach ◽  
Postconcussion Symptoms

ObjectiveMild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes, but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict postconcussion symptoms following an mTBI.Data sourcesSearches of MEDLINE, Embase, CENTRAL, CINAHL, Web of Science, PsycBITE and PsycINFO up to October 2016.Data selection and extractionTwo reviewers independently screened for potentially eligible studies, extracted data and assessed the overall quality of evidence by outcome using the Grading of Recommendations Assessment, Development and Evaluation approach.ResultsA total of 23 298 citations were obtained from which 166 manuscripts were reviewed. Thirty-six cohort studies (2812 patients) having enrolled between 7 and 311 patients (median 89) fulfilled our inclusion criteria. Most studies excluded patients based on advanced age (n=10 (28%)), neurological disorders (n=20 (56%)), psychiatric disorders (n=17 (47%)), substance abuse disorders (n=13 (36%)) or previous traumatic brain injury (n=10 (28%)). Twenty-one studies (58%) used at least two of these exclusion criteria. The pooled mean age of included patients was 39.3 (SD 4.6) years old (34 studies). The criteria used to define a mTBI were inconsistent. The most frequently reported outcome was postconcussion syndrome using the Rivermead Post-Concussion Symptoms Questionnaire (n=18 (50%)) with follow-ups ranging from 7 days to 5 years after the mTBI.ConclusionsMost studies have recruited samples that are not representative and generalisable to the mTBI population. These exclusion criteria limit the potential use and translation of promising serum protein biomarkers to predict postconcussion symptoms.

scholarly journals Neurosensory Deficits Vary as a Function of Point of Care in Pediatric Mild Traumatic Brain Injury

2018 ◽  
Vol 35 (10) ◽  
pp. 1178-1184 ◽  
Author(s):  
Andrew R. Mayer ◽  
Christopher Wertz ◽  
Sephira G. Ryman ◽  
Eileen P. Storey ◽  
Grace Park ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Point Of Care

scholarly journals FDG-PET imaging in mild traumatic brain injury: a critical review

2014 ◽  
Vol 5 ◽  
Author(s):  
Kimberly R. Byrnes ◽  
Colin M. Wilson ◽  
Fiona Brabazon ◽  
Ramona von Leden ◽  
Jennifer S. Jurgens ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Pet Imaging ◽  
Critical Review ◽  
Fdg Pet

scholarly journals The Current State of Traumatic Brain Injury Biomarker Measurement Methods

Biosensors ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 319
Author(s):  
Alyse D. Krausz ◽  
Frederick K. Korley ◽  
Mark A. Burns
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Point Of Care ◽  
Future Research ◽  
Protein Biomarkers ◽  
Research Directions ◽  
Current State ◽  
Diagnosis And Classification ◽  
Future Research Directions ◽  
Measurement Devices

Traumatic brain injury (TBI) is associated with high rates of morbidity and mortality partially due to the limited tools available for diagnosis and classification. Measuring panels of protein biomarkers released into the bloodstream after injury has been proposed to diagnose TBI, inform treatment decisions, and monitor the progression of the injury. Being able to measure these protein biomarkers at the point-of-care would enable assessment of TBIs from the point-of-injury to the patient’s hospital bedside. In this review, we provide a detailed discussion of devices reported in the academic literature and available on the market that have been designed to measure TBI protein biomarkers in various biofluids and contexts. We also assess the challenges associated with TBI biomarker measurement devices and suggest future research directions to encourage translation of these devices to clinical use.

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