Versatile polymer-based strategies for antibacterial drug delivery systems and antibacterial coatings

2022 ◽  
Author(s):  
Kexin You ◽  
Bin Gao ◽  
Meiyu Wang ◽  
Xiaoyu Wang ◽  
Kingsley Chidiebere Okoro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Health ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Bacterial Resistance ◽  
Economic Losses ◽  
Antibacterial Drug ◽  
Antibacterial Materials ◽  
Human Health Damage ◽  
Health Damage

Human health damage and economic losses due to bacterial infections are very serious worldwide. Excessive use of antibiotics has caused an increase in bacterial resistance. Fortunately, various non-antibiotic antibacterial materials...

Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

2019 ◽  
Vol 56 (2) ◽  
pp. 396-398
Author(s):  
Georgeta Zegan ◽  
Daniela Anistoroaei ◽  
Elena Mihaela Carausu ◽  
Eduard Radu Cernei ◽  
loredana Golovcencu
Keyword(s):  
Drug Delivery ◽  
Clavulanic Acid ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Intracellular Transport ◽  
Oral Treatment ◽  
Chitosan Nanoparticles ◽  
Well Being ◽  
Cell Penetrating ◽  
Novel Drug

Amoxicillin and clavulanic acid are two of the most commonly prescribed antibacterial worldwide for treating oral infectious diseases. Oral health is of big importance for well-being and general health. A few novel drug delivery systems were designed for oral treatment and prophylaxis of different diseases in the oral cavity. This work focused on the latest drug delivery development of the most common oral pathologies, namely, periodontitis, oral mucosal infections, dental caries and oral cancer. Herein we reveal the synthesis, characterization and application of chitosan nanoparticles for intracellular transport of the weakly cell-penetrating amoxicillin and clavulanic acid in order to improve their efficacy on bacterial infections.

scholarly journals Assessing local impacts of water use on human health: evaluation of water footprint models in the Province Punjab, Pakistan

2021 ◽  
Author(s):  
Natalia Mikosch ◽  
Markus Berger ◽  
Elena Huber ◽  
Matthias Finkbeiner
Keyword(s):  
Human Health ◽  
Water Use ◽  
Water Deprivation ◽  
Water Footprint ◽  
Local Scale ◽  
Water Supply Systems ◽  
Domestic Water ◽  
Income Loss ◽  
Human Health Damage ◽  
Health Damage

Abstract Purpose The water footprint (WF) method is widely applied to quantify water use along the life cycle of products and organizations and to evaluate the resulting impacts on human health. This study analyzes the cause-effect chains for the human health damage related to the water use on a local scale in the Province Punjab of Pakistan, evaluates their consistency with existing WF models, and provides recommendations for future model development. Method Locally occurring cause-effect chains are analyzed based on site observations in Punjab and a literature review. Then, existing WF models are compared to the findings in the study area including their comprehensiveness (covered cause-effect chains), relevance (contribution of the modeled cause-effect chain to the total health damage), and representativeness (correspondence with the local cause-effect chain). Finally, recommendations for the development of new characterization models describing the local cause-effect chains are provided. Results and discussion The cause-effect chains for the agricultural water deprivation include malnutrition due to reduced food availability and income loss as well as diseases resulting from the use of wastewater for irrigation, out of which only the first one is addressed by existing WF models. The cause-effect chain for the infectious diseases due to domestic water deprivation is associated primarily with the absence of water supply systems, while the linkage to the water consumption of a product system was not identified. The cause-effect chains related to the water pollution include the exposure via agricultural products, fish, and drinking water, all of which are reflected in existing impact assessment models. Including the groundwater compartment may increase the relevance of the model for the study area. Conclusions Most cause-effect chains identified on the local scale are consistent with existing WF models. Modeling currently missing cause-effect chains for the impacts related to the income loss and wastewater usage for irrigation can enhance the assessment of the human health damage in water footprinting.

Human health damage caused by particulate matter PM10 and ozone in urban environments: the case of Athens, Greece

2013 ◽  
Vol 185 (8) ◽  
pp. 6933-6942 ◽  
Author(s):  
P. A. Kassomenos ◽  
K. Dimitriou ◽  
A. K. Paschalidou
Keyword(s):  
Particulate Matter ◽  
Human Health ◽  
Urban Environments ◽  
Human Health Damage ◽  
Health Damage

scholarly journals A Human Health Toxicity Assessment of Biogas Engines Regulated and Unregulated Emissions

2020 ◽  
Vol 10 (20) ◽  
pp. 7048
Author(s):  
Alarico Macor ◽  
Alberto Benato
Keyword(s):  
Natural Gas ◽  
Human Health ◽  
Internal Combustion Engines ◽  
Impact Analysis ◽  
Health Impact ◽  
Human Health Damage ◽  
Dioxins And Furans ◽  
Health Damage ◽  
Unregulated Emissions ◽  
Biogas Engines

The aim of the work is to evaluate the damage to human health arising from emissions of in-operation internal combustion engines fed by biogas. The need of including also unregulated emissions like polycyclic aromatic hydrocarbons (PAHs), aldehydes and dioxins and furans is twofold: (i) to cover the lack in biogas engine emissions measurements and (ii) to complete the picture on biogas harmfulness to human health by identifying the substances with the highest impact. To this purpose, an experimental campaign is conducted on six biogas engines and one fed by natural gas all characterised by an electric power of 999 kWel. Collected data are used to perform an impact analysis on human health combining the Health Impact Assessment and the Risk Assessment. Measurements show that PAHs, aldehydes and diossin and furans are almost always below the detection limit, in both biogas and natural gas exhausts. The carcinogenic risk analysis of PAHs for the two fuels established their substantial equivalence. The analysis of equivalent toxicity of dioxins and furans reveals that biogas is, on average, 10 times more toxic than natural gas. Among regulated emissions, NOx in the biogas engines exhausts are three times higher than those of natural gas. They are the main contributors to human health damage, with approximately 90% of the total. SOx ranks second and accounts for about 6% of the total damage. Therefore, (i) the contribution to human health damage of unregulated emissions is limited compared to the damage from unregulated emissions, (ii) the damage per unit of electricity of biogas engines exhausts is about three times higher than that of natural gas and it is directly linked to NOx, (iii) obtaining a good estimation of the human health damage from both biogas and natural gas engines emissions is enough of a reason to consider NOx and SOx.

scholarly journals Study of subchronic toxicity of the developed antibacterial drug based on exosomal particles

2020 ◽  
Vol 175 ◽  
pp. 07002
Author(s):  
Elena Kastarnova ◽  
Vladimir Orobets ◽  
Valeria Shahova ◽  
Olga Sevostyanova ◽  
Ilya Belyaev ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Antibacterial Drug ◽  
Subchronic Toxicity ◽  
Respiratory Epithelial Cells ◽  
White Rats ◽  
Safety Parameters ◽  
Low Toxicity ◽  
Respiratory Epithelial

One of the main promising directions in the development of pharmacology is the development of drugs that provide targeted drug concentration and effective approaches to obtaining them using nanoscale drug delivery systems. In our opinion, the most promising is the use of biodegradable delivery systems due to their low toxicity and xenobiotic effects on the patient’s body. The need to develop regulated drug delivery systems is due to their clear advantage over analogues in standardized dosage forms. Based on modern research publications we have developed an exosomal antibacterial form of azithromycin that has pronounced selective properties for respiratory epithelial cells. The aim of the work was to study the safety parameters of the developed drug based on exosomal particles, in particular subchronic toxicity. For the study 3 experimental and 1 control groups of white rats weighing 190-220 g were formed with 10 heads each. The drug was administered intragastrically daily for 90 days in doses of 1/10; 1/20 and 1/50 of the LD50 set in the acute experiment. The study found that the use of the developed exosomal drug intragastrically once a day for 90 days does not affect the behavioral responses of animals and their external condition.

scholarly journals A REVIEW ON CIPROFLOXACIN: DOSAGE FORM PERSPECTIVE

2018 ◽  
Vol 10 (4) ◽  
pp. 6 ◽  
Author(s):  
M. Vidyavathi ◽  
G. Srividya
Keyword(s):  
Drug Delivery ◽  
Mechanism Of Action ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Research Work ◽  
Delivery Systems ◽  
Drug Reactions ◽  
Methods Development ◽  
Pure Drug

Ciprofloxacin (CF) is one of the topmost selling antibiotics and it is available at a cheap cost which is used to treat many bacterial infections. Many research scientists are working on this drug for various applications on different drug delivery systems. The main objective of this paper is to enlighten about the details of pure drug CF and its delivery systems along with current research on this drug. This review focused on history, pharmacokinetics, mechanism of action, types of dosage form available in the market with their cost, current research going on this drug with their applications and methods development for estimation of CF. It also highlighted the possible interactions and adverse drug reactions of CF and patents available. The present review revealed that the only analytical method for estimation of CF was developed in the first decade, few drug delivery systems (DDS) of CF were developed in the second decade and more research work on the development of novel DDS of CF founded in the last decade.

scholarly journals The influence of value choices in life cycle impact assessment of stressors causing human health damage

2012 ◽  
Vol 18 (3) ◽  
pp. 698-706 ◽  
Author(s):  
An M. De Schryver ◽  
Sebastien Humbert ◽  
Mark A. J. Huijbregts
Keyword(s):  
Life Cycle ◽  
Impact Assessment ◽  
Human Health ◽  
Life Cycle Impact Assessment ◽  
Human Health Damage ◽  
Value Choices ◽  
Health Damage ◽  
Life Cycle Impact

scholarly journals Drug delivery systems for potential treatment of intracellular bacterial infections

10.2741/3627 ◽  
2010 ◽  
Vol 15 (1) ◽  
pp. 397 ◽  
Author(s):  
Edurne Imbuluzqueta
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Potential Treatment

scholarly journals Human Health Damage Modelling in Life Cycle Assessment: A Valuable Addition to the Evaluation of Medical Interventions?

2015 ◽  
Vol 18 (7) ◽  
pp. A731
Author(s):  
S Debaveye ◽  
W De Soete ◽  
S De Meester ◽  
D Vandijck ◽  
B Heirman ◽  
...  
Keyword(s):  
Life Cycle Assessment ◽  
Life Cycle ◽  
Human Health ◽  
Medical Interventions ◽  
Valuable Addition ◽  
Damage Modelling ◽  
Human Health Damage ◽  
Health Damage

Development of human health damage factors for tropospheric ozone considering transboundary transport on a global scale

2015 ◽  
Vol 23 (12) ◽  
pp. 2339-2348 ◽  
Author(s):  
Longlong Tang ◽  
Tatsuya Nagashima ◽  
Kouichi Hasegawa ◽  
Toshimasa Ohara ◽  
Kengo Sudo ◽  
...  
Keyword(s):  
Human Health ◽  
Tropospheric Ozone ◽  
Global Scale ◽  
Human Health Damage ◽  
Health Damage ◽  
Transboundary Transport
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