scholarly journals Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)

2002 ◽  
Vol 361 (3) ◽  
pp. 443 ◽  
Author(s):  
Alesia M. HRUSKA-HAGEMAN ◽  
John A. WEMMIE ◽  
Margaret P. PRICE ◽  
Michael J. WELSH
Keyword(s):  
Ion Channel ◽  
Sodium Channels ◽  
Na Channel ◽  
Synaptic Protein ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

scholarly journals Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions

2021 ◽  
Vol 12 ◽  
Author(s):  
Ibitayo Abigail Ademuwagun ◽  
Solomon Oladapo Rotimi ◽  
Steffen Syrbe ◽  
Yvonne Ukamaka Ajamma ◽  
Ezekiel Adebiyi
Keyword(s):  
Ion Channel ◽  
Sodium Channel ◽  
Sodium Channels ◽  
De Novo ◽  
Single Gene ◽  
Voltage Gated ◽  
Functional Studies ◽  
Voltage Gated Sodium Channels ◽  
Genomic Studies ◽  
The Brain

Genetic epilepsy occurs as a result of mutations in either a single gene or an interplay of different genes. These mutations have been detected in ion channel and non-ion channel genes. A noteworthy class of ion channel genes are the voltage gated sodium channels (VGSCs) that play key roles in the depolarization phase of action potentials in neurons. Of huge significance are SCN1A, SCN1B, SCN2A, SCN3A, and SCN8A genes that are highly expressed in the brain. Genomic studies have revealed inherited and de novo mutations in sodium channels that are linked to different forms of epilepsies. Due to the high frequency of sodium channel mutations in epilepsy, this review discusses the pathogenic mutations in the sodium channel genes that lead to epilepsy. In addition, it explores the functional studies on some known mutations and the clinical significance of VGSC mutations in the medical management of epilepsy. The understanding of these channel mutations may serve as a strong guide in making effective treatment decisions in patient management.

Fast and Slow Activation Kinetics of Voltage-Gated Sodium Channels in Molluscan Neurons

1997 ◽  
Vol 77 (5) ◽  
pp. 2373-2384 ◽  
Author(s):  
William F. Gilly ◽  
Rhanor Gillette ◽  
Matthew McFarlane
Keyword(s):  
Sodium Channels ◽  
Voltage Dependence ◽  
Na Channel ◽  
Molluscan Neurons ◽  
Na Channels ◽  
Activation Kinetics ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Voltage Dependent ◽  
Kinetics Of

Gilly, William F., Rhanor Gillette, and Matthew McFarlane. Fast and slow activation kinetics of voltage-gated sodium channels in molluscan neurons. J. Neurophysiol. 77: 2373–2384, 1997. Whole cell patch-clamp recordings of Na current ( I Na) were made under identical experimental conditions from isolated neurons from cephalopod ( Loligo, Octopus) and gastropod ( Aplysia, Pleurobranchaea, Doriopsilla) species to compare properties of activation gating. Voltage dependence of peak Na conductance ( g Na) is very similar in all cases, but activation kinetics in the gastropod neurons studied are markedly slower. Kinetic differences are very pronounced only over the voltage range spanned by the g Na-voltage relation. At positive and negative extremes of voltage, activation and deactivation kinetics of I Na are practically indistinguishable in all species studied. Voltage-dependent rate constants underlying activation of the slow type of Na channel found in gastropods thus appear to be much more voltage dependent than are the equivalent rates in the universally fast type of channel that predominates in cephalopods. Voltage dependence of inactivation kinetics shows a similar pattern and is representative of activation kinetics for the two types of Na channels. Neurons with fast Na channels can thus make much more rapid adjustments in the number of open Na channels at physiologically relevant voltages than would be possible with only slow Na channels. This capability appears to be an adaptation that is highly evolved in cephalopods, which are well known for their high-speed swimming behaviors. Similarities in slow and fast Na channel subtypes in molluscan and mammalian neurons are discussed.

scholarly journals Erratum to: Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?

2020 ◽  
Author(s):  
Zhi-mei Li ◽  
Li-xia Chen ◽  
Hua Li
Keyword(s):  
Open Access ◽  
Sodium Channels ◽  
Voltage Gated ◽  
Internet Portal ◽  
Creative Commons ◽  
Link Type ◽  
Voltage Gated Sodium Channels

The article “Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?”, written by Zhi-mei LI, Li-xia CHEN, Hua LI, was originally published electronically on the publisher’s internet portal on December 2019 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The original article has been corrected.Corresponding authors: Li-xia CHEN, Hua LI

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