Cleavage, a real turn-off? HIV-mediated proteolysis of PABP1
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In this issue of the Biochemical Journal, Álvarez and colleagues have identified PABP1 [poly(A)-binding protein 1] as a target of protease cleavage during HIV infection. The study shows that HIV-1, HIV-2 and mouse mammary tumour virus, but not other retroviruses, target PABP1 for cleavage and identifies cleavage sites within the RNA-recognition motifs and C-terminal region of the protein. This suggests that PABP1 cleavage may be important in the shut-off of host translation during HIV infection. This extends the viral families that are known to target PABP1 to include Retroviridae, suggesting that PABP1 may be a central target of viral infection.
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1993 ◽
Vol 268
(20)
◽
pp. 15080-15087
1998 ◽
Vol 18
(2)
◽
pp. 685-693
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