The birth of proteoglycans: the nature of the link between protein and carbohydrate of a chondroitin sulfate complex from hyaline cartilage

2007 ◽  
pp. c2
Author(s):  
Tim E Hardingham
Keyword(s):  
Chondroitin Sulfate ◽  
Hyaline Cartilage ◽  
Sulfate Complex

Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil

2010 ◽  
Vol 80 (1) ◽  
pp. 168-173 ◽  
Author(s):  
Liangliang Huang ◽  
Weiping Sui ◽  
Yuanxiu Wang ◽  
Qiang Jiao
Keyword(s):  
Controlled Release ◽  
Chondroitin Sulfate ◽  
Sulfate Complex

Toxicodynamic Evaluation of a Cisplatin–Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells

Renal Failure ◽  
2011 ◽  
Vol 33 (6) ◽  
pp. 609-614
Author(s):  
Jing-Shi Zhang ◽  
Daisuke Kadowaki ◽  
Hiroshi Nonoguchi ◽  
Sumio Hirata ◽  
Hakaru Seo ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Sulfate Complex ◽  
Proximal Tubular ◽  
Perfused Kidney

scholarly journals Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

2019 ◽  
Vol 14 (1) ◽  
pp. 40-51 ◽  
Author(s):  
Zar Chi Soe ◽  
Bijay Kumar Poudel ◽  
Hanh Thuy Nguyen ◽  
Raj Kumar Thapa ◽  
Wenquan Ou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chondroitin Sulfate ◽  
Cancer Cells ◽  
Sulfate Complex ◽  
Colorectal Cancer Cells

scholarly journals Properties of aqueous dispersion of chitosan and chondroitin sulfate complex derived from aquatic organisms

Vestnik MGTU ◽  
2016 ◽  
Vol 19 (3) ◽  
pp. 585-592
Author(s):  
V. Yu. Novikov ◽  
◽  
N. V. Dolgopyatova ◽  
I. N. Konovalova ◽  
Yu. A. Kuchina ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Aqueous Dispersion ◽  
Aquatic Organisms ◽  
Sulfate Complex

scholarly journals Chondroprotectors: A range of application in general somatic practice

2017 ◽  
Vol 89 (5) ◽  
pp. 98-104 ◽  
Author(s):  
O A Shavlovskaya
Keyword(s):  
Articular Cartilage ◽  
Chondroitin Sulfate ◽  
Disease Progression ◽  
Hyaline Cartilage ◽  
Functional Disorders ◽  
Dosing Regimen ◽  
Metabolic Processes ◽  
Progressive Loss ◽  
Optimal Dosing ◽  
Pain Symptoms

Chondroprotectors (CP) are biological agents that contribute to the regeneration of the cartilage surfaces and articular capsule, participating in the metabolic processes of the articular cartilage. Progressive loss of hyaline cartilage and lower levels of chondroitin sulfate were observed in osteoarthritis (OA) at different sites, including dorsopathy. OA therapy is aimed at slowing disease progression, relieving pain symptoms, and reducing functional disorders. For this purpose, oral or injectable CPs (Chondroguard, Sustaguard) are prescribed. The optimal dosing regimen of parenteral CPs is the following: three intramuscular Chondrogard 1 ml (100 mg) jections during the first week; 25—30 intramuscular chondroguard 2 ml (200 mg) injections every other day during the second week, a repeat cycle after 6 months; Sustaguard 400 mg thrice weekly for 4 weeks.

Mussel-Inspired Tissue-Adhesive Hydrogel Based on the Polydopamine–Chondroitin Sulfate Complex for Growth-Factor-Free Cartilage Regeneration

2018 ◽  
Vol 10 (33) ◽  
pp. 28015-28026 ◽  
Author(s):  
Lu Han ◽  
Menghao Wang ◽  
Pengfei Li ◽  
Donglin Gan ◽  
Liwei Yan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chondroitin Sulfate ◽  
Cartilage Regeneration ◽  
Tissue Adhesive ◽  
Sulfate Complex

Generation of scaffold incorporated with nanobioglass encapsulated in chitosan/chondroitin sulfate complex for bone tissue engineering

2020 ◽  
Vol 153 ◽  
pp. 1-16 ◽  
Author(s):  
Bhisham Narayan Singh ◽  
Vivek Veeresh ◽  
Sarada Prasanna Mallick ◽  
Shivam Sinha ◽  
Amit Rastogi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Chondroitin Sulfate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sulfate Complex

Preparation and properties of chitosan chondroitin sulfate complex microcapsules

2008 ◽  
Vol 65 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Weiping Sui ◽  
Liangliang Huang ◽  
Jun Wang ◽  
Qibing Bo
Keyword(s):  
Chondroitin Sulfate ◽  
Sulfate Complex

Effect of Glycosaminoglycans on Thrombin- and Atroxin-Induced Fibrin Assembly and Structure

1989 ◽  
Vol 62 (04) ◽  
pp. 1057-1061 ◽  
Author(s):  
Marcus E Carr ◽  
Patrick L Powers
Keyword(s):  
Chondroitin Sulfate ◽  
Fiber Diameter ◽  
Lag Phase ◽  
Low Molecular Weight ◽  
Fibrin Gels ◽  
Fiber Size ◽  
Induced Changes ◽  
The Impact ◽  
Fiber Radius ◽  
Turbidity Increase

SummaryThis study was performed to quantitate the impact of several glycosaminoglycans (GAG) on fibrin assembly and structure. Gel formation was monitored as the increase in optical density at 633 nm subsequent to thrombin (2 NIH u/ml) or atroxin (0.10 mg/ml) addition to solutions of buffered fibrinogen (1 mg/ml) or plasma. Gel absorbance was measured as a function of wavelength (400 to 800 nm) and gel fiber diameter and mass/length ratio (μ) were calculated. Chondroitin sulfate A (CSA)shortened the lag phase, enhanced the maximal rate of turbidity increase, and increased the final gel turbidity of fibrin gels formed by thrombin or atroxin. CSA (16 mg/ml) increased fiber μ from 1.3 to 3.1 × 1013 dalton/cm and fiber radius from 6.0 to 8.6 × 10-6 cm in thrombin-induced gels. μ increased from 0.7 to 2.7 × 1013 dalton/cm and fiber radius from 4 to 7.8 × 10-6 cm for atroxin-induced gels. Above 16 mg/ml, CSA caused fibrinogen precipitation in purified solutions but not in plasma. CSA inhibited thrombin-induced plasma clotting of plasma but effects in atroxin-mediated plasma gels paralleled those seen in purified solutions. Chondroitin sulfate B (CSB)-induced changes in fibrin were similar but slightly less dramatic than those seen with CSA. μ increased from 0.9 to 2.0 × 1013 dalton/cm for thrombin-induced fibrin gels and from 0.8 to 2.3 × 1013 dalton/cm for atroxininduced gels. Low molecular weight heparin (Mr = 5100) slowed fibrin assembly and reduced fiber size by 50% in thrombininduced gels. Changes in μ of atroxin-induced gels were much less pronounced (<20%). This study documents pronounced GAGinduced changes in fibrin structure which vary with GAG species and may mediate significant physiologic functions.

The Gut Microbiota of Rats under Experimental Osteoarthritis and Administration of Chondroitin Sulfate and Probiotic

2020 ◽  
Vol 82 (6) ◽  
pp. 64-73
Author(s):  
O.H. Korotkyi ◽  
◽  
T.V. Luhovska ◽  
T.M. Serhiychuk ◽  
K.O. Dvorshchenko ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Chondroitin Sulfate ◽  
Joint Inflammation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Quantitative Composition ◽  
Combined Administration ◽  
Osteoarthritis Progression ◽  
Experimental Osteoarthritis ◽  
Gut Microbiota Composition

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and joint inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome and inflammation, two important components of osteoarthritis progression. Aim. In this study we investigated the effect of chondroitin sulfate and probiotics on the gut microbiome in monoiodoacetate-induced osteoarthritis model in rats. Methods. The species and quantitative composition of feces were determined using diagnostic media with selective properties. Further identification of isolated microorganisms was carried out according to morphological, tinctorial, physiological and metabolic parameters. The results are presented in the form of lg CFU/g. Results. Induction of osteoarthritis caused significant increasing the number of opportunistic enterobacteria and lactose-negative Escherichia coli against the decreasing of lacto- and bifidobacteria that may indicate a dysbiotic condition. Coadministration of chondroitin sulfate and probiotic bacteria has led to improvement the quantitative composition of the gut microbiota in experimental animals, the numerous of Bifidobacterium, Lactobacillus were increasing against decreasing the quantitative composition of opportunistic microorganisms. Conclusions. Monoiodoacetate-induced osteoarthritis caused dysbiosis of gut in rat. We observed beneficial effect of combined administration of chondroitin sulfate and probiotics on gut microbiota composition in rats with experimental osteoarthritis. Thus, adding of supplements like probiotics to standard treatment of osteoarthritis may have potentials to prevent and treat this disease.

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