Mussel-Inspired Tissue-Adhesive Hydrogel Based on the Polydopamine–Chondroitin Sulfate Complex for Growth-Factor-Free Cartilage Regeneration

2018 ◽  
Vol 10 (33) ◽  
pp. 28015-28026 ◽  
Author(s):  
Lu Han ◽  
Menghao Wang ◽  
Pengfei Li ◽  
Donglin Gan ◽  
Liwei Yan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chondroitin Sulfate ◽  
Cartilage Regeneration ◽  
Tissue Adhesive ◽  
Sulfate Complex

Tissue-Adhesive Chondroitin Sulfate Hydrogel for Cartilage Reconstruction

2021 ◽  
Author(s):  
Jisoo Shin ◽  
Eun Hye Kang ◽  
Soojeong Choi ◽  
Eun Je Jeon ◽  
Jung Ho Cho ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Tissue Adhesive ◽  
Cartilage Reconstruction

Combined Effects of Bone Marrow-Derived Mesenchymal Stem Cells and PLGA-PEG-PLGA Scaffolds on Repair of Articular Cartilage Defect

2013 ◽  
Vol 815 ◽  
pp. 345-349 ◽  
Author(s):  
Ching Wen Hsu ◽  
Ping Liu ◽  
Song Song Zhu ◽  
Feng Deng ◽  
Bi Zhang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Defect ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
Cartilage Defects

Here we reported a combined technique for articular cartilage repair, consisting of bone arrow mesenchymal stem cells (BMMSCs) and poly (dl-lactide-co-glycolide-b-ethylene glycol-b-dl-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers carried with tissue growth factor (TGF-belat1). In the present study, BMMSCs seeded on PLGA-PEG-PLGA with were incubated in vitro, carried or not TGF-belta1, Then the effects of the composite on repair of cartilage defect were evaluated in rabbit knee joints in vivo. Full-thickness cartilage defects (diameter: 5 mm; depth: 3 mm) in the patellar groove were either left empty (n=18), implanted with BMMSCs/PLGA (n=18), TGF-belta1 modified BMMSCs/PLGA-PEG-PLGA. The defect area was examined grossly, histologically at 6, 24 weeks postoperatively. After implantation, the BMMSCs /PLGA-PEG-PLGA with TGF-belta1 group showed successful hyaline-like cartilage regeneration similar to normal cartilage, which was superior to the other groups using gross examination, qualitative and quantitative histology. These findings suggested that a combination of BMMSCs/PLGA-PEG-PLGA carried with tissue growth factor (TGF-belat1) may be an alternative treatment for large osteochondral defects in high loading sites.

scholarly journals Additive Benefits of Chondroitin Sulfate and Oriented Tethered Epidermal Growth Factor for Vascular Smooth Muscle Cell Survival

2014 ◽  
Vol 14 (5) ◽  
pp. 720-730 ◽  
Author(s):  
Pauline Lequoy ◽  
Benoît Liberelle ◽  
Gregory De Crescenzo ◽  
Sophie Lerouge
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Chondroitin Sulfate ◽  
Cell Survival ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Epidermal Growth

Chondroitin sulfate cross-linked three-dimensional tailored electrospun scaffolds for cartilage regeneration

2022 ◽  
pp. 112643
Author(s):  
Yujie Chen ◽  
Wei Xu ◽  
Muhammad Shafiq ◽  
Daiying Song ◽  
Xianrui Xie ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Three Dimensional ◽  
Cartilage Regeneration ◽  
Electrospun Scaffolds

Transforming growth factor-β1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury

2009 ◽  
Vol 1263 ◽  
pp. 10-22 ◽  
Author(s):  
Jiarong Yin ◽  
Kazuma Sakamoto ◽  
Haoqian Zhang ◽  
Zenya Ito ◽  
Shiro Imagama ◽  
...  
Keyword(s):  
Brain Injury ◽  
Growth Factor ◽  
Chondroitin Sulfate ◽  
Transforming Growth Factor ◽  
Keratan Sulfate ◽  
Transforming Growth Factor Β1

scholarly journals Comparative Analysis of Adipose-Derived Stromal Cells and Their Secretome for Auricular Cartilage Regeneration

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Se-Joon Oh ◽  
Kyung-Un Choi ◽  
Sung-Won Choi ◽  
Sung-Dong Kim ◽  
Soo-Keun Kong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Stromal Cells ◽  
Collagen Type ◽  
Cartilage Regeneration ◽  
Cartilage Defects ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Auricular Cartilage ◽  
Adipose Derived Stromal Cells

Adipose-derived stromal cells (ADSCs) can repair auricular cartilage defects. Furthermore, stem cell secretome may also be a promising biological therapeutic option, which is equal to or even superior to the stem cell. We explored the therapeutic efficacies of ADSCs and their secretome in terms of rabbit auricular cartilage regeneration. ADSCs and their secretome were placed into surgically created auricular cartilage defects. After 4 and 8 weeks, the resected auricles were histopathologically and immunohistochemically examined. We used real-time PCR to determine the levels of genes expressing collagen type II, transforming growth factor-β1 (TGF-β1), and insulin-like growth factor-1 (IGF-1). ADSCs significantly improved auricular cartilage regeneration at 4 and 8 weeks, compared to the secretome and PBS groups, as revealed by gross examination, histopathologically and immunohistochemically. ADSCs upregulated the expression of collagen type II, TGF-β1, and IGF-1 more so than did the secretome or PBS. The expression levels of collagen type II and IGF-1 were significantly higher at 8 weeks than at 4 weeks after ADSC injection. Although ADSCs thus significantly enhanced new cartilage formation, their secretome did not. Therefore, ADSCs may be more effective than their secretome in the repair of auricular cartilage defect.

Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration

2019 ◽  
Vol 7 (15) ◽  
pp. 2442-2453 ◽  
Author(s):  
Caoxin Tang ◽  
Brian D. Holt ◽  
Zoe M. Wright ◽  
Anne M. Arnold ◽  
Alexandra C. Moy ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Cartilage Regeneration ◽  
Functionalized Graphene ◽  
Injectable Hydrogel ◽  
Amine Functionalized ◽  
Cartilage Therapy

Chemically functionalized graphene covalently reactsin situwith chondroitin sulfate to form an enhanced, injectable hydrogel for potential cartilage therapy.

Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil

2010 ◽  
Vol 80 (1) ◽  
pp. 168-173 ◽  
Author(s):  
Liangliang Huang ◽  
Weiping Sui ◽  
Yuanxiu Wang ◽  
Qiang Jiao
Keyword(s):  
Controlled Release ◽  
Chondroitin Sulfate ◽  
Sulfate Complex
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