scholarly journals Histology and molecular pathology of iliotibial tract contracture in patients with gluteal muscle contracture

2019 ◽  
Vol 39 (9) ◽  
Author(s):  
Bang-tuo Yuan ◽  
Feng Qu ◽  
Shao-xia Wang ◽  
Wei Qi ◽  
Xue-zhen Shen ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Molecular Pathology ◽  
Tissue Repair ◽  
Gluteal Muscle ◽  
Muscle Contracture ◽  
Iliotibial Tract ◽  
Protein Levels ◽  
Gluteal Muscle Contracture ◽  
Repair Genes ◽  
Mrna Expression Levels

Abstract The present study aimed to examine the pathologic changes of the iliotibial tract and discusses its relationship with gluteal muscle contracture. Samples of contractual iliotibial tracts were collected from six patients with contractures of the gluteal muscles and iliotibial tracts during their surgical treatment. Samples of normal iliotibial tracts were collected from six patients receiving surgeries for avascular necrosis of the femoral head who had no contractures of the gluteal muscles and iliotibial tracts. The tissue samples were stained using Hematoxylin and Eosin (H&E), Masson’s trichrome, and Sirius Red. The mRNA and protein levels of various tissue repair genes were determined using quantitative real-time PCR and Western blotting. Both the normal and contractual iliotibial tracts consisted of type I and III collagens. The contractual iliotibial tracts had a significantly higher proportion of type III collagen in comparison with the normal iliotibial tracts. The mRNA expression levels and protein levels of tissue repair genes TGFβ 1, bFGF, and matrix metalloproteinase-1 (MMP-1) in the contractual iliotibial tracts were up-regulated in comparison with that in the normal iliotibial tracts. However, the mRNA expression levels and protein levels of tissue inhibitors of metalloproteinase-1 (TIMP) in the contractual iliotibial tracts were down-regulated in comparison with that in the normal iliotibial tracts. The contractures of both the gluteal muscles and the iliotibial tracts share similar histology and molecular pathology. Our results indicate that iliotibial tract contracture is secondary to the gluteal muscle contracture and is a constant tissue repair process.

New Minimally Invasive Option for the Treatment of Gluteal Muscle Contracture

Orthopedics ◽  
2012 ◽  
Vol 35 (12) ◽  
pp. e1692-e1698 ◽  
Author(s):  
Bin Ye ◽  
Panyu Zhou ◽  
Yan Xia ◽  
Youyan Chen ◽  
Jun Yu ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Gluteal Muscle ◽  
Muscle Contracture ◽  
Gluteal Muscle Contracture

Unilateral labyrinthectomy induced changes on GDNF receptor complex proteins in the rat medial vestibular nuclei

2007 ◽  
Vol 16 (4-5) ◽  
pp. 171-177
Author(s):  
Adrian Lozada ◽  
Kaj Karlstedt ◽  
Pertti Panula ◽  
Antti A. Aarnisalo
Keyword(s):  
Mrna Expression ◽  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
Receptor Complex ◽  
Trophic Effect ◽  
Expression Levels ◽  
Protein Levels ◽  
Unilateral Labyrinthectomy ◽  
Ganglion Neurons ◽  
Mrna Expression Levels

In the auditory periphery, GDNF has been shown to have a trophic effect to spiral ganglion neurons, both during development and in adult animals. We have studied the effect of unilateral labyrinthectomy (UL) on protein levels and expression of GDNF multicomponent receptor complex: the ret tyrosine kinase and coreceptor GFRα-1 in the medial vestibular nucleus of the adult rat. GFRα-1 protein levels display an increasing trend in ipsilateral medial vestibular nucleus culminating at 48 h post UL. On the other hand, GFRα-1 mRNA expression levels in ipsi- and contralateral medial vestibular nucleus show a steadily decreasing trend that is significant at 1 week post-lesion. Protein levels for c-Ret isoforms also show an initial bilateral decreasing trend that ceases at 48 h in ipsilateral medial vestibular nucleus but persists on the contralateral side. c-Ret mRNA expression levels show a significant decrease at 4 h post UL followed by another significant decrease 1 week post UL. Our data would suggest that neurotrophins belonging to the GDNF family are involved in this model of post-lesional CNS plasticity.

scholarly journals Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture

2014 ◽  
Vol 56 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Xintao Zhang ◽  
Yukun Ma ◽  
Tian You ◽  
Xiaopeng Tian ◽  
Honglei Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Gluteal Muscle ◽  
Muscle Contracture ◽  
Smad Signaling ◽  
Gluteal Muscle Contracture ◽  
Smad Signaling Pathway

Comparison of Endoscopic Surgery and Open Surgery for Gluteal Muscle Contracture

2011 ◽  
Vol 31 (5) ◽  
pp. e38-e43 ◽  
Author(s):  
Dehao Fu ◽  
Shuhua Yang ◽  
Baojun Xiao ◽  
Hong Wang ◽  
Chunqing Meng
Keyword(s):  
Endoscopic Surgery ◽  
Open Surgery ◽  
Gluteal Muscle ◽  
Muscle Contracture ◽  
Gluteal Muscle Contracture

scholarly journals Aberrant Femoral Torsion Presenting with Frog-leg Squatting Mimicking Gluteal Muscle Contracture

2011 ◽  
Vol 470 (4) ◽  
pp. 1165-1170 ◽  
Author(s):  
Chia-Ling Chiang ◽  
Meng-Yuan Tsai ◽  
Wei-Ning Chang ◽  
Clement Kuen-Huang Chen
Keyword(s):  
Gluteal Muscle ◽  
Femoral Torsion ◽  
Muscle Contracture ◽  
Gluteal Muscle Contracture

scholarly journals Z-Plasty for Severe Gluteal Muscle Contracture in Children

2016 ◽  
Vol 24 (3) ◽  
pp. 383-386
Author(s):  
Kun Zha ◽  
Guohui Liu ◽  
Shuhua Yang ◽  
Faqi Cao
Keyword(s):  
Treatment Outcome ◽  
Pelvic Tilt ◽  
Functional Score ◽  
Leg Length ◽  
Gluteal Muscle ◽  
Muscle Contracture ◽  
Length Discrepancy ◽  
Gluteal Muscle Contracture ◽  
The Mean

Purpose To review the records of 363 patients with severe gluteal muscle contracture to determine its mechanism, underlying pathology, and treatment outcome. Methods Records of 136 males and 227 females aged 5 to 18 (mean, 12.2) years who underwent Z-plasty for bilateral (n=347) or unilateral (n=16) severe gluteal muscle contracture were reviewed. Severe gluteal muscle contracture was classified as typical (n=52) or special (n=311). The typical type is associated with symptoms of positive out-toe gait, Ober sign, back-extending test, cross-leg test, squatting with knee side-by-side test, and hip dysfunction. It is further subdivided into mild (n=0), moderate (n=40), or severe (n=12). The special type is associated with additional symptoms of pelvic tilt and leg length discrepancy (<2 cm in 181 hips, 2–4 cm in 82 hips, and >4 cm in 48 hips). 311 hips had pelvic tilt and 47 hips had lumbar compensatory scoliosis. Treatment outcome was assessed at 6 months. Hip functional score was assessed at the final follow-up. Results The mean hospitalisation period was 11 days. After a mean follow-up of 1.5 years, the mean hip functional score improved from 8.03 to 11.69; improvement was higher in children (age 5–13 years) than in adolescents (age 14–18 years) [3.7 vs. 2.9, p<0.001]. At 6 months, outcome was excellent in 280 hips, good in 80, fair in 3 hips, and poor in 0. The 3 hips with fair outcome had persistent slight pelvic tilt and swaying gait. Two of them had preoperative leg length discrepancy >4 cm, and intra-operatively the contracture band severely affected the joint capsule. The third patient did not comply with postoperative exercises. Conclusion Surgical treatment for severe gluteal muscle contracture achieved good outcome.

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