The dissection of the upstream regulatory elements of the Inositol 1,4,5-trisphosphate receptor gene in Caenorhabditis elegans

2000 ◽  
Vol 28 (5) ◽  
pp. A177-A177
Author(s):  
Nicholas J. D. Gower ◽  
Gillian Temple ◽  
Denise Walker ◽  
Howard A. Baylis
Keyword(s):  
Caenorhabditis Elegans ◽  
Receptor Gene ◽  
Regulatory Elements ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

Transcription initiation sites and promoter structure of the mouse type 2 inositol 1,4,5-trisphosphate receptor gene

Gene ◽  
1997 ◽  
Vol 196 (1-2) ◽  
pp. 181-185 ◽  
Author(s):  
Kiyoshi Morikawa ◽  
Tetsuya Ohbayashi ◽  
Midori Nakagawa ◽  
Yoshiyuki Konishi ◽  
Yasutaka Makino ◽  
...  
Keyword(s):  
Transcription Initiation ◽  
Receptor Gene ◽  
Promoter Structure ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

scholarly journals The Type 1 Inositol 1,4,5-Trisphosphate Receptor Gene Is Altered in theopisthotonosMouse

1997 ◽  
Vol 17 (2) ◽  
pp. 635-645 ◽  
Author(s):  
Valerie A. Street ◽  
Martha M. Bosma ◽  
Vasiliki P. Demas ◽  
Melissa R. Regan ◽  
Doras D. Lin ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

DNA sequences of RAPD fragments in artiodactyls

Genome ◽  
1996 ◽  
Vol 39 (2) ◽  
pp. 456-458 ◽  
Author(s):  
Silja Kostia ◽  
Jukka Palo ◽  
Sirkka-Liisa Varvio
Keyword(s):  
Dna Sequences ◽  
Sequence Similarity ◽  
Receptor Gene ◽  
Chromosome 2 ◽  
High Sequence Similarity ◽  
Microsatellite Repeats ◽  
Rapd Profile ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

A bovine RAPD profile, generated by a 10-mer primer, was analysed by sequencing the major fragments. Three of four different fragments showed homologies to previously characterized mammalian sequences. One was 61–66% identical to LINE sequences and another was 78.5% identical to a human chromosome 2 sequence tagged site. The third fragment was 93.1% identical to the human type 2 inositol 1,4,5-trisphosphate receptor gene. This fragment had counterparts in white-tailed deer and reindeer; fragments of slightly different size in these species showed high sequence similarity and the size differences were due to varying numbers of dinucleotide microsatellite repeats inside the fragment. Key words : RAPD, artiodactyls, sequence similarity, microsatellites, type 2 inositol 1,4,5-trisphosphate receptor.

scholarly journals The Inositol 1,4,5-Trisphosphate Receptor Regulates Epidermal Cell Migration in Caenorhabditis elegans

2004 ◽  
Vol 14 (20) ◽  
pp. 1882-1887 ◽  
Author(s):  
Christina L. Thomas-Virnig ◽  
Paul A. Sims ◽  
Jeffrey S. Simske ◽  
Jeff Hardin
Keyword(s):  
Cell Migration ◽  
Caenorhabditis Elegans ◽  
Epidermal Cell ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

scholarly journals Inositol 1,4,5-Trisphosphate Signaling Regulates Rhythmic Contractile Activity of Myoepithelial Sheath Cells in Caenorhabditis elegans

2004 ◽  
Vol 15 (8) ◽  
pp. 3938-3949 ◽  
Author(s):  
Xiaoyan Yin ◽  
Nicholas J.D. Gower ◽  
Howard A. Baylis ◽  
Kevin Strange
Keyword(s):  
Caenorhabditis Elegans ◽  
Contractile Activity ◽  
Receptor Gene ◽  
Tyrosine Kinase Receptor ◽  
Sheath Cell ◽  
Cell Contraction ◽  
C Elegans ◽  
Inositol 1,4,5 Trisphosphate ◽  
Intracellular Ca ◽  
Sheath Cells

Intercellular communication between germ cells and neighboring somatic cells is essential for reproduction. Caenorhabditis elegans oocytes are surrounded by and coupled via gap junctions to smooth muscle-like myoepithelial sheath cells. Rhythmic sheath cell contraction drives ovulation and is triggered by a factor secreted from oocytes undergoing meiotic maturation. We demonstrate for the first time that signaling through the epidermal growth factor-like ligand LIN-3 and the LET-23 tyrosine kinase receptor induces ovulatory contractions of sheath cells. Reduction-of-function mutations in the inositol 1,4,5-trisphosphate (IP3) receptor gene itr-1 and knockdown of itr-1 expression by RNA interference inhibit sheath contractile activity. itr-1 gain-of-function mutations increase the rate and force of basal contractions and induce tonic sheath contraction during ovulation. Sheath contractile activity is disrupted by RNAi of plc-3, one of six phospholipase C-encoding genes in the C. elegans genome. PLC-3 is a PLC-γ homolog and is expressed in contractile sheath cells of the proximal gonad. Maintenance of sheath contractile activity requires plasma membrane Ca2+ entry. We conclude that IP3 generated by LET-23 mediated activation of PLC-γ induces repetitive intracellular Ca2+ release that drives rhythmic sheath cell contraction. Calcium entry may function to trigger Ca2+ release via IP3 receptors and/or refill intracellular Ca2+ stores.

Disruption of the type 1 inositol 1,4,5-trisphosphate receptor gene suppresses the morphine-induced antinociception in the mouse

2003 ◽  
Vol 350 (2) ◽  
pp. 69-72 ◽  
Author(s):  
Takeshi Aoki ◽  
Minoru Narita ◽  
Orie Ohnishi ◽  
Keisuke Mizuo ◽  
Michiko Narita ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

scholarly journals Transcriptional Regulation of Mouse Type 1 Inositol 1,4,5-Trisphosphate Receptor Gene by NeuroD-Related Factor

2001 ◽  
Vol 72 (4) ◽  
pp. 1717-1724 ◽  
Author(s):  
Yoshiyuki Konishi ◽  
Noriaki Ohkawa ◽  
Yasutaka Makino ◽  
Hiroaki Ohkubo ◽  
Ryoichiro Kageyama ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Receptor Gene ◽  
Related Factor ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

Demonstration of an E-box and Its CNS-Related Binding Factors for Transcriptional Regulation of the Mouse Type 1 Inositol 1,4,5-Trisphosphate Receptor Gene

2002 ◽  
Vol 69 (2) ◽  
pp. 476-484 ◽  
Author(s):  
Yoshiyuki Konishi ◽  
Yasushi Kobayashi ◽  
Toshihiko Kishimoto ◽  
Yasutaka Makino ◽  
Atsushi Miyawaki ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Receptor Gene ◽  
Inositol 1,4,5 Trisphosphate ◽  
E Box ◽  
Trisphosphate Receptor
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