Not just a writer: PRC2 as a chromatin reader
Keyword(s):
PRC2 deposits the H3K27me3 repressive mark, which facilitates transcription repression of developmental genes. The decision of whether a particular gene is silenced at a given point during development is heavily dependent on the chromatin context. More than just a simple epigenetic writer, PRC2 employs several distinct chromatin reading capabilities to sense the local chromatin environment and modulate the H3K27me3 writer activity in a context-dependent manner. Here we discuss the complex interplay of PRC2 with the hallmarks of active and repressive chromatin, how it affects H3K27me3 deposition and how it guides transcriptional activity.
2014 ◽
Vol 84
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pp. 79-91
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2017 ◽
Vol 61
(9)
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pp. 1600879
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2010 ◽
Vol 107
(27)
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pp. 12345-12350
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2007 ◽
Vol 104
(48)
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pp. 19011-19016
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Keyword(s):
2008 ◽
Vol 317
(2)
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pp. 417-429
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2006 ◽
Vol 281
(19)
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pp. 13134-13140
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