Uric Acid in Advanced Renal Failure

1972 ◽  
Vol 43 (3) ◽  
pp. 331-341 ◽  
Author(s):  
G. M. Danovitch ◽  
J. Weinberger ◽  
G. M. Berlyne
Keyword(s):  
Renal Failure ◽  
Uric Acid ◽  
Renal Tubule ◽  
Tubular Secretion ◽  
Acid Excretion ◽  
Acid Transport ◽  
Uric Acid Excretion ◽  
Striking Increase ◽  
Suppression Test ◽  
Diseased Kidney

1. The results of studies of renal uric acid excretion in eleven patients with advanced chronic renal failure are presented. 2. The pyrazinamide suppression test was used to separate secretion from reabsorption of uric acid in the renal tubule. 3. There is a marked increase in the excretion and clearance of uric acid as renal function deteriorates. This was due to a striking increase in tubular secretion of urate and to incomplete reabsorption of filtered urate. 4. The remarkable functional capacity of the remaining nephrons of the chronically diseased kidney with respect to uric acid transport might be due to a uricosuric factor in uraemic serum.

Effect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken

1960 ◽  
Vol 198 (3) ◽  
pp. 575-580 ◽  
Author(s):  
Lawrence Berger ◽  
T'sai Fan Yü ◽  
Alexander B. Gutman
Keyword(s):  
Uric Acid ◽  
Tubular Secretion ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Acid Clearance ◽  
Uric Acid Clearance ◽  
Tubular Transport ◽  
Renal Tubular Transport ◽  
The Mean ◽  
Renal Tubular

In 43 chickens, the mean Cinulin was 4.7 ± 1.8 ml/min. (1.8 ± 0.8 ml/kg/min.), mean Curate 29.0 ± 14.9 ml/min. (11.3 ± 6.0 ml/kg/min.) and mean Turate 1.30 ± 0.69 mg/min. (0.48 ± 0.24 mg/kg/min.). Tubular secretion accounted for a mean of 81% of the total urinary urate. Probenecid, sulfinpyrazone, zoxazolamine and high dosages of phenylbutazone, all uricosuric in man, reduced urate excretion in the chicken, apparently by suppressing tubular secretion of urate; CPAH also was reduced. Salicylate, in doses uricosuric in man, had no effect on chicken urate excretion. Pyrazinamide and sodium r-lactate, agents which decrease urate excretion in man, did not alter urate excretion in the chicken. PAH loading experiments demonstrated that as TPAH increased, Turate decreased. These latter findings suggest competition of urate and PAH for renal tubular transport in the chicken.

Tubular Urate Transporter Gene Polymorphisms Differentiate Patients with Gout Who Have Normal and Decreased Urinary Uric Acid Excretion

2014 ◽  
Vol 41 (9) ◽  
pp. 1863-1870 ◽  
Author(s):  
Rosa J. Torres ◽  
Eugenio de Miguel ◽  
Rebeca Bailén ◽  
José R. Banegas ◽  
Juan G. Puig
Keyword(s):  
Uric Acid ◽  
Tubular Secretion ◽  
Dietary Control ◽  
Nucleotide Polymorphisms ◽  
Transporter Gene ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Control Subjects ◽  
Urate Transporter ◽  
Primary Gout

Objective.Primary gout has been associated with single-nucleotide polymorphisms (SNP) in several tubular urate transporter genes. No study has assessed the association of reabsorption and secretion urate transporter gene SNP with gout in a single cohort of documented primary patients with gout carefully subclassified as normoexcretors or underexcretors.Methods.Three reabsorption SNP (SLC22A12/URAT1, SLC2A9/GLUT9, and SLC22A11/OAT4) and 2 secretion transporter SNP (SLC17A1/NPT1 and ABCG2/BRCP) were studied in 104 patients with primary gout and in 300 control subjects. The patients were subclassified into normoexcretors and underexcretors according to their serum and 24-h urinary uric acid levels under strict conditions of dietary control.Results.Compared with control subjects, patients with gout showed different allele distributions of the 5 SNP analyzed. However, the diagnosis of underexcretor was only positively associated with the presence of the T allele of URAT1 rs11231825, the G allele of GLUT9 rs16890979, and the A allele of ABCG2 rs2231142. The association of the A allele of ABCG2 rs2231142 in normoexcretors was 10 times higher than in underexcretors. The C allele of NPT1 rs1165196 was only significantly associated with gout in patients with normal uric acid excretion.Conclusion.Gout with uric acid underexcretion is associated with transporter gene SNP related mainly to tubular reabsorption, whereas uric acid normoexcretion is associated only with tubular secretion SNP. This finding supports the concept of distinctive mechanisms to account for hyperuricemia in patients with gout with reduced or normal uric acid excretion.

Effect of urine flow rate on uric acid excretion in man

1972 ◽  
Vol 15 (4) ◽  
pp. 338-346 ◽  
Author(s):  
Herbert S. Diamond ◽  
Robert Lazarus ◽  
David Kaplan ◽  
David Halberstam
Keyword(s):  
Uric Acid ◽  
Flow Rate ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals Effect of pentose ingestion on uric acid excretion

1929 ◽  
Vol 23 (6) ◽  
pp. 1175-1177
Author(s):  
Kate Madders ◽  
Robert Alexander McCance
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals POS1144 SERUM URIC ACID TO CREATININE RATIO IS ASSOCIATED WITH URINARY URIC ACID EXCRETION IN PATIENTS WITH GOUT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 851.2-851
Author(s):  
Z. Zhong ◽  
Y. Huang ◽  
X. Huang ◽  
Q. Huang ◽  
Y. Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Output ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Binary Logistic Regression Analysis ◽  
Creatinine Ratio ◽  
Acid Excretion ◽  
Complete Collection ◽  
Uric Acid Excretion

Background:Underexcretion of uric acid is the dominant mechanism leading to hyperuricemia [1] and the 24-hour urinary uric acid excretion is an important measurement. However, it is inconvenient due to accurate timing and complete collection of the specimen.Objectives:The aim of this study was to investigate the relationship between serum uric acid to creatinine ratio (sUACR) and 24-hour urinary uric acid excretion in gout patients.Methods:A total of 110 gout patients fulfilling 2015 ACR/EULAR classification criteria from Guangdong Second Provincial General Hospital from January 2019 to January 2021 were retrospectively enrolled in this study. Patients were divided into underexcretion group (<3600 μmol/24h) and non-underexcretion group (≥3600 μmol/24h). The correlation between sUACR and 24-hour urinary uric acid excretion was analyzed by the Pearson’s correlations analysis. Receiver operation characteristic (ROC) curves were performed to assess the utility of sUACR for discriminating between underexcretion group and non-underexcretion group. Furthermore, the risk factors of uric acid underexcretion were evaluated using binary logistic regression analysis.Results:sUACR in the underexcretion group was significantly lower than the non-underexcretion group (p=0.0001). Besides, sUACR was positively correlated with 24-hour urinary uric acid excretion (r=0.4833, p<0.0001). Furthermore, ROC suggested that the area under the curve (AUC) of sUACR was 0.728, which was higher that of serum uric acid and creatinine. The optimal cutoff point of sUACR was 5.2312, with a sensitivity and specificity of 71.9% and 67.9%. Logistic analysis results revealed that decreased sUACR (<5.2312) was an independent risk factor of underexcretion of uric acid (OR =5.510, 95% CI: 1.952-15.550, P=0.001).Conclusion:sUACR is lower in gout patients with underexcretion of uric acid and may serve as a useful and convenient marker of assessing underexcretion of uric acid in gout patients.References:[1]Perez-Ruiz F, Calabozo M, Erauskin GG, Ruibal A, Herrero-Beites AM. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 2002; 47: 610–13.Figure 1.A. Comparison of serum uric acid to creatinine ratio between underexcretion group and non-underexcretion group. B. Correlation between serum uric acid to creatinine ratio and 24h uric acid excretion.Disclosure of Interests:None declared.

Uric acid excretion in normal children

1978 ◽  
Vol 92 (6) ◽  
pp. 911-914 ◽  
Author(s):  
F. Bruder Stapleton ◽  
Michael A. Linshaw ◽  
Khatab Hassanein ◽  
Alan B. Gruskin
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Normal Children ◽  
Uric Acid Excretion

Uric acid excretion in infants and children

1971 ◽  
Vol 32 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Helen K. Berry ◽  
Mary Granger
Keyword(s):  
Uric Acid ◽  
Infants And Children ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
In Infants And Children

scholarly journals THE EFFECTIVENESS OF RENALOF® COMPARED TO KALKURENAL® AND PLACEBO

2012 ◽  
Vol 19 (2) ◽  
Author(s):  
Benny Kristyantoro ◽  
Sabilal Alif ◽  
Tarmono Djojodimedjo ◽  
Budiono Budiono
Keyword(s):  
Uric Acid ◽  
Surface Area ◽  
Renal Calculi ◽  
Renal Calculus ◽  
Renal Ultrasound ◽  
Acid Excretion ◽  
Stone Surface ◽  
Adjunct Therapy ◽  
Uric Acid Excretion ◽  
Plain Abdominal Film

Objective: To compare the effectiveness after administration of Renalof to Kalkurenal and placebo in patient with renal calculus. Material & Method: We analyzed 30 patient with renal calculi less than or equal to 20 mm (2 cm) between January 2011 and March 2011. Patients were divided into 3 groups. Nine patients were treated with placebo, 8 patients were treated with Kalkurenal and the last 13 patients were treated with Renalof. After 30 days, we analyzed calcium and uric acid excretion for 24 hours and measured the stone with plain abdominal film and renal ultrasound. Results: There were decreased in excretion of calcium and uric acid all of patients but not significant statistically (p > 0,05) and there were significant decreased on stone measurement in patient treated with Renalof. Conclusion: Renalof  can be given as adjunct therapy for patient with renal calculi. Keywords: Calcium and uric acid excretion in urine 24 hours, stone measurement and stone surface area.

scholarly journals Combined Supplementation with Glycine and Tryptophan Reduces Purine-Induced Serum Uric Acid Elevation by Accelerating Urinary Uric Acid Excretion: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2562
Author(s):  
Oshima ◽  
Shiiya ◽  
Nakamura
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Water Solubility ◽  
Elevated Serum ◽  
Acid Excretion ◽  
Japanese Adult ◽  
Urinary Ph ◽  
Uric Acid Excretion ◽  
Combined Supplementation ◽  
Single Blind

The authors previously confirmed the serum uric acid-lowering effects of the combination of glycine and tryptophan in subjects with mild hyperuricemia. This study examined whether combined supplementation with glycine and tryptophan suppressed the elevation in serum uric acid levels caused by purine ingestion and accelerated urinary uric acid excretion in subjects with lower urate excretion using a randomized, single-blind, placebo-controlled, crossover clinical trial design. Healthy Japanese adult males with lower urate excretion ingested water containing purines in addition to dextrin (placebo), tryptophan, glycine, or a glycine and tryptophan mixture. The combined supplementation with glycine and tryptophan significantly reduced the elevated serum uric acid levels after purine ingestion. Glycine alone and in combination with tryptophan significantly increased urinary uric acid excretion and urate clearance compared with the effects of the placebo. Urinary pH increased by the ingestion of the mixture. These results suggested that the improved water solubility of uric acid due to increased urinary pH contributed to the increase of urinary uric acid excretion.

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