Technique for Rapid Control of Hypertension with Oral Minoxidil

1974 ◽  
Vol 48 (s2) ◽  
pp. 185s-187s ◽  
Author(s):  
K. O'Malley ◽  
J. L. McNay
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Cumulative Dose ◽  
Blood Pressure Response ◽  
Pressure Control ◽  
Time Interval ◽  
Achieve Blood Pressure ◽  
Rapid Control ◽  
Blood Pressure Responses ◽  
The Relationship

1. Twelve patients with essential hypertension were treated aggressively with minoxidil in order to achieve blood pressure control as rapidly as possible. 2. After an initial dose of 5 mg, dose increments were administered 6 hourly until a fall in blood pressure was observed. 3. The size of additional doses was determined by the magnitude of and response to the lowest effective dose and the therapeutic objective. 4. Over a time-interval of 24–42 h blood pressure was reduced to normal or near normal in each case. 5. Analysis of the relationship between blood pressure response and cumulative dose indicates that at sub-optimum blood pressure responses it is safe and efficacious to give half the antecedent cumulative dose as a single dose in arriving at the therapeutic objective.

scholarly journals Blood Pressure Control and Exaggerated Blood Pressure Response in Nigerians with Essential Hypertension

2014 ◽  
Vol 8 ◽  
pp. CMC.S15961
Author(s):  
Olugbenga O. Abiodun ◽  
Michael O. Balogun ◽  
Rasaaq A. Adebayo ◽  
Anthony O. Akintomide
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Essential Hypertension ◽  
Exercise Testing ◽  
Blood Pressure Response ◽  
Pressure Control ◽  
General Linear Model ◽  
Pressure Response ◽  
Chi Square ◽  
Key Factor

Background Blood pressure (BP) control in hypertensives is important in preventing cardiovascular (CV) morbidity and mortality. This work was done to assess control of BP among Nigerian hypertensives at rest and during exercise. Materials and Methods A total of 85 male hypertensives were recruited consecutively and had clinical evaluation and treadmill (TM) exercise testing using the Bruce protocol. Independent t-test, chi-square, and Fisher's exact tests were used to compare patients with controlled and uncontrolled BP using SPSS version 16 software. Adjustment for confounders was by logistic regression and general linear model. Results Resting systolic BP (rSBP) (mmHg) and resting diastolic BP (rDBP) (mmHg) were significantly lower in the controlled group (115.0 ± 12.29, 133.1 ± 12.27, P = < 0.001 and 76.00 ± 6.55, 91.4 ± 8.00, P = < 0.001). The proportion of subjects with controlled BP was 37.7%. Adjusted peak SBP (PSBP) during exercise (mmHg) was significantly higher in the uncontrolled than in the controlled group (210.5 ± 27.31, 191.8 ± 20.77, P = 0.001). Adjusted exaggerated blood pressure response (EBPR) was found in 37 subjects (44%) in the uncontrolled group while seven subjects (0.1%) had EBPR in the controlled group ( P = 0.003). Conclusion This study shows that EBPR is significantly higher in subjects with uncontrolled BP compared with those with controlled BP. Therefore, good BP control may be the key factor in preventing EBPR in hypertensives.

scholarly journals Prolonged duration of blood pressure response to enalkiren, the novel dipeptide renin inhibitor, in essential hypertension.

Hypertension ◽  
1990 ◽  
Vol 15 (6_pt_2) ◽  
pp. 835-840 ◽  
Author(s):  
R S Boger ◽  
H N Glassman ◽  
J H Cavanaugh ◽  
P J Schmitz ◽  
J Lamm ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Renin Inhibitor ◽  
The Novel ◽  
Prolonged Duration

ABPM Comparison of the Anti-Hypertensive Profiles of Telmisartan and Enalapril in Patients with Mild-to-Moderate Essential Hypertension

2002 ◽  
Vol 30 (6) ◽  
pp. 543-552 ◽  
Author(s):  
J Amerena ◽  
S Pappas ◽  
J-P Ouellet ◽  
L Williams ◽  
D O'Shaughnessy
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Monitoring ◽  
Study Drug ◽  
Pressure Control ◽  
Moderate Essential Hypertension ◽  
Open Label ◽  
Night Time ◽  
Once Daily

In this multicentre, prospective, randomized, open-label, blinded-endpoint (PROBE) study, the efficacy of 12 weeks' treatment with once-daily telmisartan 40–80 mg and enalapril 10–20 mg was evaluated using ambulatory blood pressure monitoring (ABPM) in 522 patients with mild-to-moderate essential hypertension. Patients were titrated to the higher dose of study drug at week 6 if mean seated diastolic blood pressure (DBP) was ≥ 90 mmHg. The primary endpoint was the change from baseline in ambulatory DBP in the last 6 h of the 24-h dosing interval after 12 weeks' treatment. Telmisartan and enalapril produced similar reductions from baseline in DBP and systolic blood pressure (SBP) over all ABPM periods evaluated (last 6 h, 24-h, daytime and night-time). Telmisartan produced a significantly greater reduction in mean seated trough DBP, measured unblinded with an automated ABPM device in the clinic, amounting to a difference of −2.02 mmHg ( P < 0.01). A significantly greater proportion of patients achieved a seated diastolic response with telmisartan than enalapril (59% versus 50%; P < 0.05), also measured with the same ABPM device. Both treatments were well tolerated. Compared with telmisartan, enalapril was associated with a higher incidence of cough (8.9% versus 0.8%) and hypotension (3.9% versus 1.1%). Therefore, telmisartan may provide better long-term compliance and, consequently, better blood pressure control than enalapril.

scholarly journals 24-Hour blood pressure response to lower dose (30 mg) fimasartan in Korean patients with mild to moderate essential hypertension

2017 ◽  
Vol 32 (6) ◽  
pp. 1025-1036 ◽  
Author(s):  
Hae-Young Lee ◽  
Cheol-Ho Kim ◽  
Jae-Kwan Song ◽  
Shung Chull Chae ◽  
Myung Ho Jeong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Response ◽  
Moderate Essential Hypertension ◽  
Pressure Response ◽  
Korean Patients

Abstract 208: Action of Multifaceted Microglia on Blood Pressure Control

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
You Li ◽  
Liang Li ◽  
Zhiying Shan ◽  
Kenneth E Bernstein ◽  
Xiao Shen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Neuronal Plasticity ◽  
Microglial Activation ◽  
Myeloid Cell ◽  
Mannose Receptor ◽  
Pressure Control ◽  
Ang Ii ◽  
Differentiation Markers ◽  
Microglial Cell Line ◽  
Blood Pressure Responses

Microglia are the resident surveillance cells in the CNS, and are involved in shaping neuronal plasticity. Previous studies show that hypertension is associated with neuroinflammation. Interference of neuroinflammation by targeting microglia can inhibit or attenuate hypertension. To investigate the phenotypic changes of microglia during hypertension, we compared the profiles of microglia dissociated from normotensive and Ang II-induced hypertensive mice by flow cytometry. We found significant increases in the expression of CD89 (76%), CCR7 (52%), IFNγR (150%), MHC II (85%), CCR2 (51%), IL-4R (164%), mannose receptor (61%) and CD36 (60%) in Ang II microglia compared to the controls. To understand whether the microglial activation has a direct effect on blood pressure, we utilized microglia adoptive transfer strategy via intracerebroventricular (ICV) injection and then examined the blood pressure responses. Mouse microglial cell line, N9, was stimulated in groups as follows: 1) medium control, 2) 10 ng/ml LPS, 3)10 ng/ml LPS + 100 μM minocycline. After 6 hr treatment, half a million N9 cells were transferred into mice via ICV injection. Twenty-four hr later, the recipient mice were anesthetized, cannulated and positioned on the stereotaxic frame. The baseline blood pressure and heart rates were similar among groups (82±2 mmHg, 328±12.8 bpm). However, when we injected Ang II (50 ng in 1μl, ICV), there was a significant prolonged response in the recipient mice transferred with LPS-primed microglia compared to the ones receiving naïve controls (LPS 817±170 sec vs. control 475±70 sec; P<0.05 by unpaired T-test). This increase was fully abolished by co-incubation with minocycline, an inhibitor for microglial activation (LPS+minocycline 507±33 sec). There were no differences observed in pressure magnitude to ICV Ang II across the groups (11±2 mmHg). These data suggest that activated microglia alter neuronal plasticity and potentiate the neuronal responses to Ang II challenge. Taken together, microglial cells are activated, manifested by up-regulation of myeloid cell differentiation markers during hypertension, and then participate in the modulation of blood pressure.

scholarly journals The Adaptive Value and Clinical Significance of Allostatic Blood Pressure Variation

2019 ◽  
Vol 15 (2) ◽  
pp. 93-104 ◽  
Author(s):  
Gary D. James
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Pressure Variation ◽  
The Body ◽  
Nocturnal Blood Pressure ◽  
Adaptive Value ◽  
Actual Nature ◽  
Blood Pressure Variation ◽  
Blood Pressure Responses ◽  
Everyday Living

In recent years, there has been interest in evaluating the morbidity and mortality risk of circadian, diurnal, or nocturnal blood pressure variation. Variation is a normative property of blood pressure, necessary for survival. Like many physiological functions, blood pressure undergoes allostasis, meaning that the body does not defend a particular blood pressure value, but rather blood pressure maintains bodily stability through continual change that is initiated by constantly fluctuating internal and external environmental stimuli. Because of its allostatic and adaptive properties, the blood pressure response to unusual situations like a visit to the clinic can lead to misdiagnosis of hypertension. However, blood pressure variation is mostly ignored when evaluating hypertension, which is an arbitrary dichotomy. Whether variation is indicative of pathology should be determined by assessing its appropriateness for the circumstance, which requires quantification of the sources and extent of normative blood pressure responses to everyday living. These responses will vary among populations due to evolutionary genetic differences. The inconsistency of reports regarding aspects of ambulatory blood pressure variation as cardiovascular risk factors likely results from the fact that the measures used do not reflect the actual nature of blood pressure allostasis.

Blood pressure control in pregnant rabbits: norepinephrine and prostaglandin interactions

1984 ◽  
Vol 247 (5) ◽  
pp. R786-R791 ◽  
Author(s):  
R. Venuto ◽  
I. Min ◽  
P. Barone ◽  
A. Donker ◽  
E. Cunningham
Keyword(s):  
Blood Pressure ◽  
Pressor Response ◽  
Pressure Control ◽  
Systemic Blood Pressure ◽  
Blood Levels ◽  
Adrenergic Blockade ◽  
Resting Blood Pressure ◽  
Pge2 Concentration ◽  
The Relationship ◽  
Hypotensive Response

The relationship between norepinephrine (NE) and prostaglandins in the regulation of systemic blood pressure during pregnancy was examined in conscious rabbits. The arterial prostaglandin E2 (PGE2) concentration was higher in pregnant than in nonpregnant rabbits. Resting blood pressure was slightly lower in the gravid animals. The pressor response to incremental doses of intravenous NE was blunted in the pregnant rabbits. Meclofenamate, a cyclooxygenase inhibitor, failed to alter the resting blood pressure in either group of animals, although it reduced PGE2 levels more than 60% in the pregnant rabbits. The pressor response to NE was significantly increased only in the pregnant rabbits when the NE infusion was repeated following meclofenamate. Pregnant rabbits could also be differentiated from nonpregnant by their higher peripheral blood levels of NE and their uniform hypotensive response to alpha-adrenergic blockade. These observations define an altered responsiveness to both endogenous and exogenous NE in pregnant rabbits that appears to be related to an increase in vasodilator prostaglandins.

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