Effects of Smoking on Oral Fat Tolerance and High Density Lipoprotein Cholesterol

1983 ◽  
Vol 65 (6) ◽  
pp. 669-672 ◽  
Author(s):  
R. S. Elkeles ◽  
S. R. Khan ◽  
V. Chowdhury ◽  
M. B. Swallow

1. Changes in serum triglyceride and high density lipoprotein (HDL) cholesterol after a fatty meal have been studied in smokers and non-smokers. 2. Average serum triglyceride during the study was higher in smokers than in non-smokers. 3. In non-smokers there was a rise in the HDL2/HDL3 cholesterol ratio after oral fat, but not in smokers. 4. These findings are compatible with the hypothesis that smoking interferes with the lipolysis of triglyceride rich lipoproteins and the conversion of HDL3 into HDL2.

2020 ◽  
Author(s):  
Na Wang ◽  
Mengjun Chen ◽  
Danhong Fang

Abstract Background The serum triglyceride to high-density lipoprotein cholesterol(TG/HDL) ratio has been identified to be positively correlated with a higher risk of sarcopenia in elderly Korean males in previous study. In this study, we aimed to discover the association between TG/HDL ratio and sarcopenia in Chinese community adults, including males and females. Methods Individuals, who participated in medical examinations at the First Affiliated Hospital of Wenzhou Medical University from May 2016 to August 2017 with the age older than 18 years, were enrolled in the study. We applied univariable and multivariable logistic regression analyses to weigh the effects of TG/HDL ratio on the status of sarcopenia. Besides, we further identified the association by subgroup analysis. Results The occurrence of sarcopenia significantly decreased with the TG/HDL ratio increased. The odds ratio(OR) of TG/HDL ratio(high vs. low) for sarcopenia was 0.408(95%CI: 0.323–0.516) by univariable analysis and 0.631 by multivariable analysis(95%CI: 0.494–0.806) respectively. Additionally, the effect of TG/HDL ratio on sarcopenia was favorable(HR < 1.0) across a majority of prespecified subgroups, except age ≥ 65 and overweight population. Conclusions TG/HDL ratio was negatively correlated with prevalence of sarcopenia in Chinese community adults, especially in individuals with the age < 65 years old and the BMI < 25 kg/m2.


VASA ◽  
2014 ◽  
Vol 43 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Yiqiang Zhan ◽  
Jinming Yu ◽  
Rongjing Ding ◽  
Yihong Sun ◽  
Dayi Hu

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.


2010 ◽  
Vol 72 (06) ◽  
pp. 806-812 ◽  
Author(s):  
Xiaoduo Fan ◽  
Emily Y. Liu ◽  
Vicki Poole Hoffman ◽  
Alison J. Potts ◽  
Bikash Sharma ◽  
...  

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