Effect of Atrial Natriuretic Factor on Bronchomotor Tone in the Normal Human Airway

1990 ◽  
Vol 79 (1) ◽  
pp. 51-55 ◽  
Author(s):  
G. Hulks ◽  
A. G. Jardine ◽  
J. M. C. Connell ◽  
N. C. Thomson
Keyword(s):  
Plasma Levels ◽  
Atrial Natriuretic Factor ◽  
Venous Blood ◽  
Normal Subjects ◽  
Asthmatic Patients ◽  
Natriuretic Factor ◽  
Normal Human ◽  
Airway Conductance ◽  
Bronchomotor Tone ◽  
Atrial Natriuretic

1. Asthmatic patients bronchodilate in response to infused atrial natriuretic factor. We wished to determine whether the airways of normal subjects responded in a similar way. 2. Changes in airway resistance, as determined by specific airway conductance, were measured in eight normal subjects in response to intravenous infusion of atrial natriuretic factor at doses of 0.5, 2 and 10 pmol rnin−1 kg−1. 3. No significant effect was observed on specific airway conductance at any rate of infusion despite maximum mean (sem) plasma levels of 597 (62) pg of atrial natriuretic factor/ml in peripheral venous blood. 4. A second study was performed using six of the eight original subjects and employing a pharmacological dose of 50 pmol of atrial natriuretic factor min−1 kg−1. This produced mean plasma levels of 2056 pg/ml and a mean increase of 31% in specific airway conductance. 5. It is concluded that pharmacological, but not pathophysiological, elevations of plasma atrial natriuretic factor may significantly alter bronchomotor tone in normal subjects.

Effects of clonidine and dihydralazine on atrial natriuretic factor and cGMP in humans

1989 ◽  
Vol 67 (3) ◽  
pp. 938-944 ◽  
Author(s):  
M. Wehling ◽  
T. Muller ◽  
J. M. Heim ◽  
R. Lorenz ◽  
H. Witzgall ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Soluble Guanylate Cyclase ◽  
Normal Subjects ◽  
Treated Group ◽  
Base Line ◽  
Hemodynamic Effects ◽  
Volume Loading ◽  
Natriuretic Factor ◽  
Basal Plasma ◽  
Atrial Natriuretic

The effects of a 1-wk treatment with clonidine (75 micrograms/day twice a day) and dihydralazine (25 mg/day twice a day) on base-line levels of plasma atrial natriuretic factor (ANF) and plasma and urinary guanosine 3′,5′-cyclic monophosphate (cGMP) and their changes by acute saline infusion (2 liters) in eight normal subjects were evaluated. Basal ANF was decreased to 65% in the clonidine group compared with both the control and dihydralazine groups. Volume loading increased plasma ANF levels by 30–40% of base-line values in the control and the dihydralazine groups and by 15% in the clonidine group. Basal plasma and urinary cGMP levels were raised by 30 and 90% in the dihydralazine group compared with both other groups. Volume loading increased plasma cGMP levels by 40% in the control and clonidine-treated groups and by 25% in the dihydralazine-treated group. It is concluded that ANF may contribute to hemodynamic effects of clonidine but not to those of dihydralazine. Dihydralazine increases plasma and urinary cGMP, supposedly by direct activation of the soluble guanylate cyclase.

Effects of Opioids on Plasma Levels of Immunoreactive Atrial Natriuretic Factor

1988 ◽  
pp. 206-211 ◽  
Author(s):  
J. Gutkowska ◽  
B. Baranowska ◽  
K. Racz ◽  
R. Garcia ◽  
G. Thibault ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Radioimmunoassay of atrial natriuretic factor: Human plasma levels

1985 ◽  
Vol 130 (2) ◽  
pp. 553-558 ◽  
Author(s):  
P. Larose ◽  
S. Meloche ◽  
P. du Souich ◽  
A. Deléan ◽  
H. Ong
Keyword(s):  
Human Plasma ◽  
Plasma Levels ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Effects of water immersion on sympathoadrenal and dopa-dopamine systems in humans

1992 ◽  
Vol 262 (6) ◽  
pp. R993-R999 ◽  
Author(s):  
E. Grossman ◽  
D. S. Goldstein ◽  
A. Hoffman ◽  
I. R. Wacks ◽  
M. Epstein
Keyword(s):  
Urinary Excretion ◽  
Plasma Levels ◽  
Water Immersion ◽  
Venous Blood ◽  
Urine Volume ◽  
Normal Subjects ◽  
Urinary Sodium Excretion ◽  
Peptide System ◽  
Triphasic Pattern ◽  
Atrial Natriuretic

Water immersion to the neck increases central blood volume and evokes a marked diuresis and natriuresis. The present study examined simultaneously effects of water immersion on activities of three endogenous systems thought to participate in sodium homeostasis: the sympathetic nervous system, the atrial natriuretic peptide system, and the renal dopa-dopamine system. Hourly urine collections and antecubital venous blood samples were obtained from 10 normal subjects before, during, and after sitting in a water-immersion tank for 3 h; four control subjects were studied while seated without immersion. Urine volume was increased by more than threefold after 1 h of immersion (from 1.2 +/- 0.2 ml/min at baseline to 5.9 +/- 0.7 ml/min, P less than 0.001) and peaked during the second hour. Urinary sodium excretion increased by more than twofold (from 103 +/- 17 mu eq/min at baseline to 196 +/- 36 mu eq/min at 1 h, P less than 0.001) and peaked during the third hour. Plasma levels and urinary excretion of norepinephrine (NE) and epinephrine were suppressed consistently during immersion (P less than 0.05). There was a marked, prompt, and sustained increase in plasma levels of immunoreactive atrial natriuretic factor (irANF) from 6.9 +/- 1.9 pg/ml baseline to 17.3 +/- 4.3 pg/ml at 1 h (P less than 0.001). Urinary excretion of dopa, dopamine, and 3,4-dihydroxyphenylglycol, a neuronal metabolite of NE, changed in a triphasic pattern, with decreased excretion during the first hour of immersion (P less than 0.01), small but consistent increases during the next 2 h, and decreased excretion, to below baseline, during recovery (P less than 0.01 for dopa and dopamine).(ABSTRACT TRUNCATED AT 250 WORDS)

Increased Plasma Atrial Natriuretic Factor and Reduced Plasma Renin in Patients with Poorly Controlled Diabetes Mellitus

1989 ◽  
Vol 77 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Gordon M. Bell ◽  
Richard K. Bernstein ◽  
John H. Laragh ◽  
Steven A. Atlas ◽  
Gary D. James ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Natriuretic Factor ◽  
Urinary Albumin Excretion ◽  
Diastolic Pressure ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Diabetic Patients ◽  
Angiotensin I ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

1. To investigate atrial natriuretic factor (ANF) and its relationship to the renin system in diabetes, we measured plasma immunoreactive ANF and plasma renin activity (PRA) in 27 non-ketotic diabetic patients without evidence of cardiac or overt renal disease, and compared them with 26 age- and sex-matched normal subjects. 2. Diabetic patients were divided prospectively into poor (PGC, n = 14) or moderate (MGC, n = 13) glycaemic control depending on their concurrent plasma glycohaemoglobin (HbA1) levels (> 9% or < 9%, respectively). Plasma ANF was elevated in PGC diabetic patients (15.7 ± 1.8 fmol/ml, mean ± sem) compared with MGC diabetics (9.9 ± 0.8 fmol/ml, P < 0.001) and normal subjects (10.1 ± 1.3 fmol/ml, P < 0.05). 3. In contrast, PRA was lower in the PGC diabetic patients (1.3 ± 0.3 pmol of angiotensin I h−1 ml−1) compared with the other groups (2.5 ± 0.5 and 2.1 ± 0.2 pmol of angiotensin I h−1 ml−1, P < 0.05). Diabetic groups had proportionally more patients with high prorenin values (over 30 ng h−1 ml−1) than the normal group, but there was no difference between the diabetic groups. 4. Among the diabetic patients, ANF was directly related to HbA1 (r = 0.49, P < 0.005) and urinary albumin excretion (r = 0.40, P < 0.02), and was inversely related to PRA (r = −0.36, P < 0.04) and plasma creatinine (r = −0.42, P < 0.02). 5. Systolic blood pressure was greater in PGC diabetic patients [133 ± 5 mmHg (17.7 ± 0.7 kPa)] than in MGC diabetic patients [117 ± 4 (15.6 ± 0.5 kPa), P < 0.05] and normal subjects [121 ± 3 (16.1 ± 0.4 kPa), P < 0.05]. Diastolic pressure was not significantly different among the groups. 6. The directionally opposite changes in plasma ANF and plasma renin in PGC diabetic patients may reflect a normal response to expansion of intravascular volume. It remains to be established whether these changes are factors in the early renal dysfunction of diabetes mellitus.

Plasma levels of atrial natriuretic factor in patients with the sleep apnea syndrome

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S234-S235 ◽  
Author(s):  
K. EHLENZ ◽  
P. SCHMIDT ◽  
T. PODSZUS ◽  
H. BECKER ◽  
H. PETER ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Plasma Levels ◽  
Atrial Natriuretic Factor ◽  
Sleep Apnea Syndrome ◽  
Natriuretic Factor ◽  
Apnea Syndrome ◽  
Atrial Natriuretic
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