Serum total sialic acid, a reputed cardiovascular risk factor, and its relationship to lipids, plasma fasting insulin, blood pressure and body mass index in normal individuals

Introduction: Cardiovascular disease (CVD) is the most common cause of death in women worldwide. Estrogen deficiency due to menopause is associated with an increased risk of this pathology. Objective: To analyze cardiovascular risk factors in perimenopausal women with at least one major modifiable cardiovascular risk factor (diabetes, hypertension, dyslipemia) between the ages of 45 and 60 of two urban primary care services. Methodology: Cross-sectional descriptive study in two health centers in the city of Ourense (Novoa Santos Health Center and A Ponte Health Center). The variables analyzed were: estrogenic activity, pharmacological treatment, smoking habit, quality of life, body mass index (BMI), total cholesterol, high density lipoprotein (cHDL), low-density lipoprotein (cLDL) and triglycerides, systolic blood pressure (TAS), diastolic blood pressure (TAD), heart rate (FC). The study was approved by the Ethics Committee of Galicia. Data analysis was performed through the free R software. Results: 316 women participated, of whom 64.9% were menopausal. The average age of the sample was 53.35 ± 4.35 years. The average BMI value was 28,125 ± 5.54 Kg/m2. 27.8% said they had a smoking habit. 77.2% of the women in the sample had total cholesterol levels ≥200 mg/dL. In relation to the cLDL, in 72.6% of the population studied it was ≥130 mg/dL. A statistically significant correlation was observed between BMI and triglyceride, cHDL, TAS, TAD and FC levels. Conclusion: Perimenopausal women had a high prevalence of smoking habit, obesity and overweight, despite suffering at least one cardiovascular risk factor. On the other hand they showed a low quality of life in both the physical and mental dimension

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Serum Sialic Acid, a Reputed Cardiovascular Risk Factor, is Elevated in South Asian Men Compared to European Men

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456329803500207 ◽

1998 ◽

Vol 35 (2) ◽

pp. 242-244 ◽

Cited By ~ 6

Author(s):

M Crook ◽

P Kerai ◽

V Andrews ◽

P Lumb ◽

R Swaminathan

Keyword(s):

Risk Factor ◽

Cardiovascular Risk ◽

Sialic Acid ◽

Racial Differences ◽

South Asian ◽

Cardiovascular Risk Factor ◽

Racial Groups ◽

Total Sialic Acid ◽

Asian Men ◽

Young Subjects

Serum total sialic acid (TSA) has recently been reported as a cardiovascular risk factor, but whether there are racial differences is not known. One hundred and twenty-four healthy young subjects (62 women and 62 men) were studied. Their age was 20.7 [0.9] years and they were matched for body mass index (BMI). Sixty-eight were of South Asian origin (37 women and 31 men) and 56 (25 women and 31 men) were European. Mean (SD) serum TSA was significantly higher in the South Asian men than the age-matched European men (74.3 [12.3]mg/dL versus 68.2 [13.0]mg/dL, P = 0.0198). In addition, serum TSA was significantly higher in South Asian women compared with European men (71.6 [8.9]mg/dL versus 68.2 [13.0]mg/dL, P = 0.0352). Finally, serum TSA was significantly higher in European women compared with European men (76.0 [13.1]mg/dL versus 69.2 [130]mg/dL, P = 0008). We conclude that serum TSA may be worth measuring in different racial groups and also may be useful to assess individuals at risk of cardiovascular disease. Large prospective studies may help to explain why serum TSA is a reputed cardiovascular risk factor and shows racial differences.

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Body mass index as a surrogate measure of cardiovascular risk factor clustering in fifth-grade children: Results from the coronary artery risk detection in the Appalachian Communities Project

International Journal of Pediatric Obesity ◽

10.1080/17477160802596197 ◽

2008 ◽

pp. 1-9

Author(s):

Christa Ice ◽

Lesley Cottrell ◽

William Neal

Keyword(s):

Body Mass Index ◽

Risk Factor ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Body Mass ◽

Cardiovascular Risk Factor ◽

Fifth Grade ◽

Risk Detection ◽

Surrogate Measure

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Serum total sialic acid, a reputed cardiovascular risk factor, and its relationship to lipids, plasma fasting insulin, blood pressure and body mass index in normal individuals

Clinical Science ◽

10.1042/cs0950053 ◽

1998 ◽

Vol 95 (1) ◽

pp. 53-57 ◽

Cited By ~ 7

Author(s):

M. CROOK ◽

P. LUMB ◽

V. ANDREWS ◽

R. SWAMINATHAN

Keyword(s):

Blood Pressure ◽

Cardiovascular Risk ◽

Sialic Acid ◽

Serum Cholesterol ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Fasting Insulin ◽

Fasting Serum ◽

Total Sialic Acid ◽

Fasting Plasma

1.Serum sialic acid is a reputed cardiovascular risk factor, but the reason why this is so is not clear. We therefore studied its relationship with other known cardiovascular risk factors (particularly those associated with insulin resistance) in 100 healthy young subjects (54 females and 46 males, age 20.7±0.89 years). 2.There was a significant univariate correlation between serum total sialic acid and fasting plasma insulin. Serum total sialic acid also correlated with fasting plasma glucose concentration and serum cholesterol and triacylglycerol. 3.In females there was a strong univariate correlation between serum total sialic acid and plasma fasting insulin and glucose concentrations, although in males there was a weaker univariate correlation between serum total sialic acid and fasting plasma glucose and the insulin resistance index. In addition, serum total sialic acid significantly correlated with systolic blood pressure, fasting serum cholesterol and triacylglycerol concentrations and body mass index in the females. In males serum total sialic acid significantly positively correlated with fasting serum cholesterol and triacylglycerol concentrations, and correlated inversely with the hip/waist ratio. 4.In multiple regression analysis of the 100 subjects serum total sialic acid correlated independently with fasting serum cholesterol, glucose and also plasma insulin concentrations. In females serum total sialic acid independently correlated with systolic and diastolic blood pressure, and serum cholesterol and fasting plasma glucose concentrations, although there was no significant independent correlation between serum total sialic acid and any of the other variables in the males.

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