Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study

2008 ◽  
Vol 115 (9) ◽  
pp. 265-271 ◽  
Author(s):  
Terho Lehtimäki ◽  
Nina Hutri-Kähönen ◽  
Mika Kähönen ◽  
Jukka Hemminki ◽  
Vera Mikkilä ◽  
...  

Individuals suffering from ATH (adult-type hypolactasia), defined by the LCT (gene encoding lactase-phlorizin hydrolase) C/C−13910 genotype (rs4988235), use less milk and dairy products and may have higher plasma HDL (high-density lipoprotein) and lower triacylglycerol (triglyceride) concentrations than their counterparts without ATH. To investigate the effects of ATH status on the early markers of atherosclerosis, we examined its association with CIMT (carotid intima-media thickness), CAC (carotid artery compliance) and brachial artery FMD (flow-mediated dilation) in a young population-based cohort of otherwise healthy individuals. As part of the Cardiovascular Risk in Young Finns Study, we performed CIMT, CAC and FMD analyses, LCT C/T−13910 genotyping and risk factor determination in 2109 young subjects 24–39 years of age (45% males) at the time of the examination. The consumption of both milk and dairy products was lowest and the consumption of alcohol highest in subjects with the C/C−13910 genotype (P<0.001 for all) in comparison with subjects without ATH (TT+CT). In multivariate analysis, no significant association between ATH status and CIMT, CAC or brachial artery FMD was found after adjustment for the use of alcohol, dairy products and all other major risk factors of coronary artery disease. In otherwise similar statistical analysis, the results remained non-significant when females and males were analysed in their own groups. In conclusion, the finding does not support the involvement of ATH in the pathogenesis of early atherosclerosis.

2017 ◽  
Vol 52 (6) ◽  
pp. e157-e164 ◽  
Author(s):  
Laura Pulkki-Råback ◽  
Marko Elovainio ◽  
Christian Hakulinen ◽  
Jari Lipsanen ◽  
Laura D. Kubzansky ◽  
...  

2007 ◽  
Vol 156 (2) ◽  
pp. 279-284 ◽  
Author(s):  
G D Norata ◽  
M Ongari ◽  
K Garlaschelli ◽  
S Raselli ◽  
L Grigore ◽  
...  

Objective: The role of resistin in insulin sensitivity and obesity is controversial. Some authors suggest that increased serum resistin levels are associated with obesity, visceral fat, insulin resistance, type 2 diabetes and inflammation, while others failed to observe such correlations. The aim of the present study was to investigate the relationship of plasma resistin levels with markers of the metabolic syndrome and atherosclerosis in a large population-based study. Design and patients: Plasma resistin levels were determined in 1090 subjects free of any medication selected from the PLIC study (designed to verify the presence of atherosclerotic lesions and progression intima-media thickness (IMT) in the common carotid artery in the general population) and related to the presence of obesity, metabolic syndrome, metabolic abnormalities, cardiovascular risk, and progression of IMT. Results: Plasma resistin levels were highly positively correlated with triglycerides, waist circumference, waist/hip ratio, systolic blood pressure, and ApoAI/ApoB ratio, while they were inversely correlated with high density lipoprotein and ApoAI levels. This finding was gender specific (mainly in women). Plasma resistin levels were significantly higher in women with the metabolic syndrome compared with controls (4.90 (0.24) ng/ml vs 3.90 (0.11) ng/ml; P<0.01), while no difference was observed in obese subjects. Finally, plasma resistin levels were significantlycorrelated with cardiovascular risk calculated according to the Framingham algorithm (P<0.01). Conclusion: Plasma resistin levels are increased in presence of the metabolic syndrome and are associated with increased cardiovascular risk.


2006 ◽  
Vol 68 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Liisa Keltikangas-Järvinen ◽  
Laura Pulkki-Råback ◽  
Sampsa Puttonen ◽  
Jorma Viikari ◽  
Olli T. Raitakari

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