Role of Integrin αE(CD103)β7 for Tissue-Specific Epidermal Localization of CD8+ T Lymphocytes

AbstractPregnancy loss (abortion) and pre-eclampsia represent the most common disorders in pregnant women. Besides infection, there are anatomical, endocrinological, genetic and immunological factors that can induce pregnancy disorders. Because the exact mechanisms of physiological pregnancy maintenance are still not clearly understood, the search for genes and proteins fulfilling this role is still in progress. One of the immune molecules that plays a beneficial role in pregnancy is the nonclassical HLA-G molecule. The molecule is mainly expressed on trophoblast cells in the foetal placenta and induces the immune tolerance of the foetus via its interaction with inhibitory receptors on maternal NK cells and CD8+ T lymphocytes. In relation to pregnancy disorders, associations between HLA-G polymorphism, HLA-G level and HLA-G function were described. Thus, the HLA-G molecule can be used as a new diagnostic marker and, potentially, for the future therapy of pregnancy disorders.

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Essential Role of Translation Factor eIF5a in Cytokine Production and Cell Cycle Regulation in Primary CD8 T Lymphocytes

SSRN Electronic Journal ◽

10.2139/ssrn.3879090 ◽

2021 ◽

Author(s):

Thomas CJ Tan ◽

Van Kelly ◽

Xiaoyan Zou ◽

Tony Ly ◽

Rose Zamoyska

Keyword(s):

Cell Cycle ◽

T Lymphocytes ◽

Cell Cycle Regulation ◽

Essential Role ◽

Cytokine Production ◽

Translation Factor ◽

Cd8 T Lymphocytes ◽

Cycle Regulation

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SP196ATHE ROLE OF CD8+ T LYMPHOCYTES IN EXPERIMENTAL NEPHROTOXIC SERUM NEPHRITIS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfy104.sp196a ◽

2018 ◽

Vol 33 (suppl_1) ◽

pp. i409-i409

Author(s):

Agnes Mooslechner ◽

Alexander Kirsch ◽

Katharina Artinger ◽

Ida Aringer ◽

Foteini Moschovaki-Filippidou ◽

...

Keyword(s):

T Lymphocytes ◽

Nephrotoxic Serum Nephritis ◽

Cd8 T Lymphocytes

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Role of CD8+ T Lymphocytes in the Pathogenesis of HIV Infection

Immunodeficiency in HIV Infection and AIDS ◽

10.1159/000421358 ◽

2015 ◽

pp. 211-218

Author(s):

Giuseppe Pantaleo ◽

Cecilia Graziosi ◽

Luca Butini ◽

Anthony S. Fauci

Keyword(s):

T Lymphocytes ◽

Hiv Infection ◽

Cd8 T Lymphocytes

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Presence of functional dendritic cells in patients chronically infected with hepatitis C virus

Blood ◽

10.1182/blood-2003-04-1339 ◽

2004 ◽

Vol 103 (3) ◽

pp. 1026-1029 ◽

Cited By ~ 111

Author(s):

Randy S. Longman ◽

Andrew H. Talal ◽

Ira M. Jacobson ◽

Matthew L. Albert ◽

Charles M. Rice

Keyword(s):

Dendritic Cells ◽

Hepatitis C Virus ◽

Hepatitis C ◽

T Lymphocytes ◽

Memory T Cells ◽

Immune Repertoire ◽

Cd8 T Lymphocytes ◽

Specific Memory ◽

Chronic Hcv

Abstract The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8+ T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-derived DCs in chronically infected patients. As it is difficult to reconcile these data with the fact that patients with chronic HCV are immune competent, we re-evaluated this finding, carefully assessing phenotypic markers and functional activity of patient DCs as compared with noninfected controls. In contrast to these prior studies, DCs from 13 of 13 chronic HCV patients expressed typical maturation markers. These mature DCs were capable of priming allogeneic T lymphocytes, as well as stimulating influenza-specific memory T cells. This finding is consistent with clinical and immunologic data that the deficit in the patient's immune repertoire is HCV-specific and suggests that refined models are required for understanding the role of DCs in HCV pathogenesis. (Blood. 2004;103:1026-1029)

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