A novel 7·9 kb deletion causing α+ -thalassaemia in two independent families of Indian origin

2003 ◽  
Vol 120 (2) ◽  
pp. 364-366 ◽  
Author(s):  
Cornelis L. Harteveld ◽  
Peter Van Delft ◽  
Pierre W. Wijermans ◽  
Mies C. Kappers-Klunne ◽  
Jitske Weegenaar ◽  
...  
Keyword(s):  
Indian Origin ◽  
Independent Families

A Case Study of Psychopathology and Personality Processes in Twins of Indian Origin

2020 ◽  
Vol 11 (01) ◽  
Author(s):  
Saranya Banerjee ◽  
Deepshikha Ray
Keyword(s):  
Twin Studies ◽  
Thematic Apperception Test ◽  
Psychometric Assessment ◽  
Intelligence Scale ◽  
Indian Origin ◽  
Thematic Apperception ◽  
Inkblot Test ◽  
Present Case Study

Twin studies have mostly focused on the pattern of maladaptive behaviour manifested by the twins and their biological basis but the findings have remained controversial till date. The present case study explores the psychopathology in 14 year old twins of Indian origin. They were referred for psychometric assessment and psychotherapy for their conduct problems. The tools administered on them during psychometric assessment are Wechsler Intelligence Scale for Children IV (WISC-IV), Rorschach Inkblot Test (RIBT) and Thematic Apperception Test (TAT). Findings are discussed in terms of the personality processes and relationship quality of the twins.

Kidney Functions and Physiological Complications in Pediatric Thalassemia Patients of Indian Origin

2019 ◽  
Vol 23 (3) ◽  
pp. 857-867
Author(s):  
Ramnath Andhale ◽  
Syed Abrar Ahmad ◽  
Sangita Lodha ◽  
Varsha Wankhade
Keyword(s):  
Indian Origin ◽  
Kidney Functions

Phytochemical screening, cytotoxicity and anti-inflammatory activities of the leaf extracts from Lawsonia inermis of Indian origin to explore its potential for medicinal uses

2020 ◽  
Vol 16 ◽  
Author(s):  
Anju Manuja ◽  
Nitu Rathore ◽  
Shalki Chaudhary ◽  
Balvinder Kumar
Keyword(s):  
Nitric Oxide ◽  
Cytotoxic Activity ◽  
Cytotoxic Effect ◽  
Vero Cells ◽  
Nitric Oxide Production ◽  
Lawsonia Inermis ◽  
Leaf Extracts ◽  
Oxide Production ◽  
Indian Origin ◽  
Anti Inflammatory

Background: Lawsonia inermis Linn popularly known as the Henna has played an important role in ayurvedic or natural herbal medicines. The presence of phyto-constituents in henna, that may affect the animal or human health adversely, need to be elucidated for L. inermis Linn species grown in India. Introduction: Introduction: The aim of this research was to perform phytochemical, cytotoxicity and anti-inflammatory studies to understand the potential of leaves of Lawsonia inermis of Indian origin to provide a way forward for therapeutic use in medicine. Methods: We assessed the phytochemical profile for presence of phyto-constituents (alkaloids, carbohydrates, glycosides, steroids, flavonoids, saponins, tannins, proteins/amino acids and gums/mucilage) from various extracts of the plant leaves’. The extracts were further purified by column chromatography for the isolation of plant constituents and monitored by TLC, analyzed by Fourier transform infrared FT-IR spectroscopy, H1NMR, and GC-MS analysis. Fractions were assessed for cytotoxicity and anti-inflammatory properties at various concentrations. We assessed the anti-inflammatory activity by nitric oxide production in various leaf extracts determined by Griess assay. Results: All the spectral results suggest that the compounds from the extract contain aromatic nucleus and OH group along with methoxy group, allyl as well as vinyl group. Fractions of chloroform/methanolic (7:3) leaf extract of Lawsonia inermis confirmed the presence of the two constituents i.e. fraxetin and 1(3H)-isobenzofuranone. We observed significant difference in cytotoxicity at higher concentrations in methanol and chloroform:methanol (8:2) leaf extracts (p>0.05), we could not find any significant differences amongst other leaf extracts at different concentrations. Some leaf extracts have potential cytotoxic activity on vero cells. Reducing the chloroform concentration during extraction decreases the cytotoxic effect on the cells. The nitric oxide levels decreased from 1000 µg/ml concentration to lower concentrations with varying degree. Overall the highest nitric oxide production by CHCl3 (70%)/ MeOH (30%) was observed amongst various fractions at different concentrations. Conclusion: The phytochemical, cytotoxicity and anti-inflammatory studies indicating the potential of leaves of the plant to provide a way further for their use in medicine. Fraxetin 1(3H)-isobenzofuranone structures were confirmed in fractions of CHCl3 (70%)/ MeOH (30%) extract as observed as a potent constituents. Some leaf extracts have potential cytotoxic activity on vero cells. Reducing the chloroform concentration during extraction decreases the cytotoxic effect on the cells.The cytotoxicity studies indicates the presence of cytotoxic compounds in some of these extracts, warranting research for fabrication of suitable formulations comprising these constituents to reduce its dose/toxicity for the use of beneficial effects of the plant components.

Insect Pests of Shorea robusta Gaertn. f. : An Update

2015 ◽  
Vol 38 (4) ◽  
pp. 313-322
Author(s):  
N. Roychoudhury
Keyword(s):  
Insect Pests ◽  
Stem Borer ◽  
North India ◽  
White Grubs ◽  
Insect Fauna ◽  
Living Tree ◽  
Shorea Robusta ◽  
Damage Seed ◽  
Indian Origin ◽  
Lepidoptera Noctuidae

Shorea robusta Gaertn. f. (Dipterocarpaceae), commonly known as sal, is one of the most important timbers of India both ecologically and economically. It is of Indian origin, widely distributed in central and north India and constitutes an important ecosystem, which provides cool and calm environment rich in biodiversity. This tree species has a highest number of insect fauna among the forest trees. Of about 346 insects recorded on sal, about 155 species of insects belonging to the order Lepidoptera (105), Coleoptera (31), Thysanoptera (9), Hemiptera (4), Orthoptera (4), Ephemeroptera (1) and Isoptera (1) are associated with living tree. The major insect pests of sal are, ‘seed and seedling borer’ Pammene theristis Meyrick (Lepidoptera: Eucosmidae), feeding on seed while they are on the tree; Sitophilus rugicollis Casey (Coleoptera : Curculionidae), damage seed either on the forest floor or during storage; white grubs such as Holotrichia spp. (Coleoptera : Scarabaeidae), which feed on the root system of the plants in nurseries and beetles feed on the foliage; defoliators such as Caviria sericea Moore (Lepidoptera : Lymantriidae), Lymantria mathura Moore (Lepidoptera : Lymantriidae), Paectes subapicalis Walker (Lepidoptera : Noctuidae), Trabala vishnou Lefebvre (Lepidoptera : Lasiocampidae), which feed on the leaves; stem borer such as Hoplocerambyx spinicornis Newman (Coleoptera : Cerambycidae) and sap sucker, such as Drosicha stebbingi Green (Hemiptera : Coccidae). Termites, such as Coptotermes curvignathus Holmgren (Isoptera : Rhinotermitidae) and timber borers, such as Sinoxylon anale and S. crassum (Coleoptera : Bostrychidae), damage sal timber in dying, felled or stored logs in depots.

An Overview on Phytochemistry, Pharmacology, Pharmaceutical, Traditional and Economical Aspects of Aegle marmelos

2021 ◽  
pp. 166-174
Author(s):  
Nikita Kumawat ◽  
Jidnyasa Pantwalawalkar ◽  
Yogini Vispute ◽  
Rahul Tade ◽  
Sopan Nangare
Keyword(s):  
Economic Importance ◽  
Chemical Profile ◽  
Aegle Marmelos ◽  
Indian Origin ◽  
Preceding Work ◽  
Long Time ◽  
Bael Powder ◽  
Anti Fungal ◽  
Wound Healing Activity ◽  
Different Parts

Aegle marmelos (A. marmelos Corr., Rutaceace) known as bael is found from pre-historic time. It belongs of Indian origin. It has abundant allegorical importance for Hindus. A. marmelos is available in diverse varieties viz. Pant Aparna, Pant Urvashi, Narendra bael-5, Narendra bael-6, Pant Sujata, Pant Shivani, CISHB-1, CISHB-2, etc. Wholly parts of the A. marmelos tree have medicinal values and have been used as medicine for a long time. A. marmelos has different classes of compounds including coumarins, alkaloids, terpenoids, fatty acids, amino acids, etc. This plant has a strong potential to treat diseases including diarrhea, dysentery, anti-bacterial, anti-fungal, diabetes, peptic ulcer, inflammation, etc. Besides, it provided anticancer, cardio-protective, antipyretic, analgesic, constipation, antioxidant, wound healing activity. The gum obtained from bael fruits has great potential in sustaining the delivery of the drug. The marketed products of A. marmelos are Chyawanprash, A. marmelos capsules, Capsule Bilv Giri, Entrostat Syrup, Ojamin, Vilwadigulika, etc. Other products made from fruit are jam, slab, dehydrated bael, fruit squash, fruit pulp Bael powder, toffee, and ready to serve (RTS) drink. Recently lots of work on different parts of bael has been establishing scientific proof for its traditional claims. Hence, it is essential to compile the current findings along with the preceding work, which will assist the researchers to find all the literature on A. marmelos. Overall, the present overview deals with general, traditional, phytopharmaceutical, pharmacological, chemical profile, and economic importance like pharmaceutical and other applications.

Growth Pattern and Use of Inter-pupillary Distance in the Detection of Ocular Hypertelorism and Hypotelorism in Indian Down Syndrome Children

2021 ◽  
Author(s):  
Anil Kumar Bhalla ◽  
Harvinder Kaur ◽  
Rupinder Kaur ◽  
Inusha Panigrahi ◽  
Brij Nandan Singh Walia
Keyword(s):  
Down Syndrome ◽  
Objective Evaluation ◽  
Age And Gender ◽  
Specific Data ◽  
Indian Origin ◽  
Serial Data ◽  
And Gender ◽  
Ocular Hypertelorism ◽  
Gender Specific ◽  
North Western

AbstractUse of inter-pupillary distance (IPD) for objective evaluation of ocular hypertelorism and hypotelorism is recommended to corroborate diagnosis of syndromic conditions. In view of complete absence of serial data on growth of IPD, this study aims to unfold auxological dynamics of IPD in Down syndrome (DS) children of Indian origin. Inner canthal distance (ICD) and outer canthal distance (OCD) were measured on a total of 1,125 (male: 752, female: 373) DS children, aged 0 to 3 months to 10 years at 6 monthly age intervals using a “Digimatic Sliding Caliper” in the Growth Laboratory/Growth Clinic of the Institute. Using Feingold and Bossert (1974) formula, IPD at each age was calculated from ICD and OCD measured among male and female DS children. IPD, like OCD and ICD increased un-interruptedly among DS children. IPD grew rapidly up to 5 years thereafter, its rapidity became slower. Boys in general, possessed larger IPD than girls, however, gender differences became statistically significant up to first 4 years of life. Our study children possessed significantly smaller IPD as compared with their normal Indian counterparts. None of our DS children depicted ocular hypertelorism while hypotelorism, was noticed amongst 4.9% male and 16.8% female DS patients. Comparison with normative IPD data failed to establish existence of ocular hypertelorism in DS children (<10 years) of north-western Indian origin. Use of age and gender-specific data presented for IPD of DS children may be made for comparative purpose to ascertain inter-population variability.

Regional strain release characteristics for Indian regions

1966 ◽  
Vol 56 (3) ◽  
pp. 749-754
Author(s):  
R. K. S. Chouhan
Keyword(s):  
Strain Accumulation ◽  
Single Cycle ◽  
Regional Strain ◽  
Indian Origin ◽  
Strain Release ◽  
Deep Focus ◽  
Shallow Focus

abstract The strain accumulation and release curves for shallow and deep focus earthquakes of Indian origin have been constructed for a span of sixty years, from 1905 to 1964. For shallow focus earthquakes, magnitudes 7.2 and above have been considered; for deep focus shocks, magnitudes 6.7 and above are used. Strain rebound characteristics yield a number of very interesting features; for example, the curve for shallow focus earthquakes shows two linear segments of strain accumulation. Deep focus shocks show a single cycle of strain accumulation. Comparison of these curves with similar curves from other regions given by Benioff are made.

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