A comparative controlled trial of intralesionally-administered zinc sulphate, hypertonic sodium chloride and pentavalent antimony compound against acute cutaneous leishmaniasis

1997 ◽  
Vol 22 (04) ◽  
pp. 169-173 ◽  
Author(s):  
K.E. SHARQUIE ◽  
R.A. NAJIM ◽  
I.B. FARJOU
Keyword(s):  
Sodium Chloride ◽  
Cutaneous Leishmaniasis ◽  
Zinc Sulphate ◽  
Controlled Trial ◽  
Antimony Compound ◽  
Pentavalent Antimony

Salt effect in hydrolysis of 3-acyl-1,3-diphenyltriazenes

1981 ◽  
Vol 46 (12) ◽  
pp. 3104-3109 ◽  
Author(s):  
Miroslav Ludwig ◽  
Oldřich Pytela ◽  
Miroslav Večeřa
Keyword(s):  
Sodium Chloride ◽  
Temperature Dependence ◽  
Potassium Chloride ◽  
Rate Constants ◽  
Zinc Sulphate ◽  
Salt Effect ◽  
Sodium Sulphate ◽  
Potassium Sulphate ◽  
Lithium Sulphate ◽  
Hydrolysis Of

Rate constants of non-catalyzed hydrolysis of 3-acetyl-1,3-diphenyltriazene (I) and 3-(N-methylcarbamoyl)-1,3-diphenyltriazene (II) have been measured in the presence of salts (ammonium chloride, potassium chloride, lithium chloride, sodium chloride and bromide, ammonium sulphate, potassium sulphate, lithium sulphate, sodium sulphate and zinc sulphate) within broad concentration ranges. Temperature dependence of the hydrolysis of the substrates studied has been measured in the presence of lithium sulphate within temperature range 20° to 55 °C. The results obtained have been interpreted by mechanisms of hydrolysis of the studied substances.

IMMUNOTHERAPY AS A TREATMENT OF AMERICAN CUTANEOUS LEISHMANIASIS: PRELIMINARY STUDIES IN BRAZIL

PEDIATRICS ◽  
1995 ◽  
Vol 95 (6) ◽  
pp. 891-891
Author(s):  
W. Mayrink ◽  
P. A. Magalhaes ◽  
M. S.M. Michalick
Keyword(s):  
Adverse Effects ◽  
Cutaneous Leishmaniasis ◽  
Rural Areas ◽  
Day Treatment ◽  
Controlled Trial ◽  
The Other ◽  
Self Administration ◽  
Cutaneous Lesions ◽  
American Cutaneous Leishmaniasis ◽  
Close Supervision

Treatment of American cutaneous leishmaniasis has been successful with antimony compounds for 80 years. There are certain conditions where the chemotherapy cannot be used—pregnant women and patients with heart or renal disease. A group in Brazil carried out a sequential trial (not a random controlled trial) of vaccine composed of killed parasites from five stocks of the leishmania, while another group received the traditional therapy of antimony. The immunotherapy program was intensive requiring 10 daily injections followed by a 10-day free period. Of 62 patients (aged 3 to 70 years) so treated, 47 (76%) were considered clinically cured; 41 required 2-10 of the 10-day treatment courses; and the other 6 required 11-19 courses. There were no adverse effects. Results were better in patients with single cutaneous and multiple cutaneous lesions, and less effective in those patients with mucocutaneous lesions. The authors make the point that because leishmaniasis occurs especially in rural areas, it would be possible to give patients a supply of syringes and vials and have self-administration at home, whereas, with the antimony treatment, close supervision of patients is necessary.

scholarly journals An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable

2006 ◽  
Vol 39 (4) ◽  
pp. 323-326 ◽  
Author(s):  
Manoel Paes de Oliveira-Neto ◽  
Marise da Silva Mattos
Keyword(s):  
Total Dose ◽  
Cutaneous Leishmaniasis ◽  
Clinical Cure ◽  
Good Tolerance ◽  
Valuable Alternative ◽  
Pentavalent Antimony ◽  
Mucosal Lesions ◽  
High Doses ◽  
Mean Time

Despite more than half a century of use in leishmaniasis, antimony therapy still presents serious problems concerning dosage and toxicity. Low and high doses have been shown to be equally effective. In this paper, the feasibility of injecting one ampoule of meglumine antimoniate intramuscularly every other day until clinical cure is demonstrated, while studying a series of 40 cutaneous leishmaniasis cases. Total dose used varied from 1,822.5 to 12,150mg of pentavalent antimony and total time of treatment varied from 3 to 10 weeks, with 86% efficacy. Thirty-six out of the 40 patients are still on follow-up with a mean time of 10.7 ± 7 months and a median of 9 months. No relapse or mucosal lesions have been noted so far. The schedule showed good tolerance and easy application and its efficacy was comparable to the officially recommended WHO schedule. Therefore, such a schedule represents a valuable alternative for the cases with high toxicicity to antimony or daily injections are an obstacle to the treatment.

scholarly journals Panniculitis Is an Important Feature of Cutaneous Leishmaniasis Pathology

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Khalifa E. Sharquie ◽  
Ammar Faisal Hameed
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Zinc Sulphate ◽  
Plasma Cells ◽  
Parasitic Infection ◽  
Histological Finding ◽  
Cellular Infiltration ◽  
Intralesional Therapy ◽  
Granulomatous Dermatitis ◽  
Perivascular Infiltration ◽  
Lobular Panniculitis

Background. Cutaneous leishmaniasis is an inflammatory parasitic infection characterized by superficial and deep perivascular infiltration with or without granuloma formation. Clinical diagnosis usually requires seeingLeishmaniabodies.Methods. We report two cases of cutaneous leishmaniasis with unusual histological finding of panniculitis. Case 1: a 36-year-old male presented with multiple ulcerative nodules involving the left leg for two months duration which was greatly responsive to antimony intralesional therapy. Case 2: A 45-year-old woman presented with painless nodules on her upper chest of a 10-week duration which were successfully treated with oral and topical zinc sulphate.Results. Diagnosis of both cases was confirmed by finding the Leishmania bodies with Gimesa stain in addition to the diffuse dermal inflammatory cellular infiltration of the dermis forming granulomatous dermatitis. Mixed cellular infiltration of lymphocytes, histiocytes, and plasma cells of the panniculus caused both septal and lobular panniculitis.Conclusion. Cutaneous leishmaniasis can cause panniculitis and this could be seen more commonly if deep biopsies were taken. So cutaneous leishmaniasis must be considered in evaluating pathology of panniculitis especially in endemic regions.

A Randomized, Placebo-Controlled Trial in Tunisia Treating Cutaneous Leishmaniasis with Paromomycin Ointment

1995 ◽  
Vol 53 (2) ◽  
pp. 162-166 ◽  
Author(s):  
A. Ben Salah ◽  
P. L. Olliaro ◽  
K. Dellagi ◽  
B. Zaafouri ◽  
A. Garraoui ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Controlled Trial
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