Graves' disease, thyroid nodules and thyroid cancer

2001 ◽  
Vol 55 (6) ◽  
pp. 711-718 ◽  
Author(s):  
Antonino Belfiore ◽  
Diego Russo ◽  
Riccardo Vigneri ◽  
Sebastiano Filetti
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Graves Disease

scholarly journals Advancements in Clinical Thyroidology in 2016

2016 ◽  
Vol 12 (02) ◽  
pp. 83
Author(s):  
Maria Brito ◽  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Thyroid Nodules ◽  
Adult Patients ◽  
Graves Disease ◽  
American Thyroid Association ◽  
Diagnosis And Management ◽  
In Pregnancy

In this article, we summarize the seminal highlights of clinical thyroidology literature published in 2016. The main focus of these articles were thyroid nodules, thyroid cancer, cubclinical hypothyroidism in pregnancy, Graves℉ disease in pregnancy, the American Thyroid Association guidelines for adult patients with thyroid nodules and differentiated thyroid cancer, and the American Thyroid Association guidelines for the diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis.

Thyroid Cancer and Nodules in Graves’ Disease: A Single Center Experience

2020 ◽  
Vol 21 ◽  
Author(s):  
Claudio Casella ◽  
Riccardo Morandi ◽  
Apollonia Verrengia ◽  
Alessandro Galani ◽  
Sarah Molfino ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Cancer Recurrence ◽  
Graves Disease ◽  
Common Complication ◽  
Single Center Experience ◽  
Operative Assessment ◽  
Risk Of Cancer ◽  
Us Scan

Background: The existence of a link between Graves’ Disease (GD) and Thyroid Cancer (TC) has long been investigated, however a clear pathogenic correlation has still to be found. Methods: In this study we analyzed retrospectively a cohort of 151 patients treated at our Clinic with total thyroidectomy between 2013 and 2018. All patients were symptomatic at the time of surgery, preoperatively ultrasonographic (US) study was performed to evaluate the presence of nodules and their distribution. All patients reached euthyroid state before surgery. Objective: We verified the presence of TC in patients submitted to surgery for GD, both with and without thyroid nodules (TN). Results: Nodules were detected in 53% of cases, above 60 y.o. at least one nodule was found, younger patients more frequently were nodules free. Bilateral diffusion of nodules appeared with increasing age. Cancer was found in 19 of 151 subjects (12.5%), all were papillary carcinomas, among them 93% were microcarcinomas. Among cancer-proven patients, 14 had thyroid nodules while 5 where nodule-free. During the follow up period no cancer recurrence was recorded. The most common complication after surgery was transient hypocalcemia (36%). Conclusions: Graves’ patients are burdened by major incidence of TC in the context of their TN. Pre-operative assessment in GD patients should consider the risk of cancer, US scan can help in rapid evaluation of nodules and new rising frontiers in molecular biomarkers analysis may help defining pathogenic basis of Graves’ neoplastic development.

scholarly journals Frequency of thyroid nodules and thyroid cancer in thyroidectomized patients with Graves’ disease

2020 ◽  
Vol 16 (2) ◽  
pp. 302-307 ◽  
Author(s):  
Caglar Keskin ◽  
Mustafa Sahin ◽  
Rovshan Hasanov ◽  
Berna Imge Aydogan ◽  
Ozgur Demir ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Graves Disease

Thyroid nodules as a risk factor for thyroid cancer in patients with Graves’ disease: A systematic review and meta‐analysis of observational studies in surgically treated patients

2019 ◽  
Vol 91 (4) ◽  
pp. 571-577 ◽  
Author(s):  
Anastasios Papanastasiou ◽  
Konstantinos Sapalidis ◽  
Dimitrios G. Goulis ◽  
Nikolaos Michalopoulos ◽  
Evangelia Mareti ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Observational Studies ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Graves Disease

scholarly journals Thyroid nodules and thyroid cancer in Graves’ disease

2014 ◽  
Vol 58 (9) ◽  
pp. 933-938 ◽  
Author(s):  
Abbas Ali Tam ◽  
Cafer Kaya ◽  
Fevzi Balkan Mehmet Kılıç ◽  
Reyhan Ersoy ◽  
Bekir Çakır
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodule ◽  
Thyroid Nodules ◽  
Neck Region ◽  
External Irradiation ◽  
Graves Disease ◽  
Irradiation Treatment ◽  
Study Results ◽  
Iodine Treatment

Objective The frequency of thyroid nodules accompanying Graves’ disease and the risk of thyroid cancer in presence of accompanying nodules are controversial. The aim of this study was to evaluate the frequency of thyroid nodules and the risk of thyroid cancer in patients operated because of graves’ disease. Subjects and methods Five hundred and twenty-six patients in whom thyroidectomy was performed because of Graves’ disease between 2006 and 2013 were evaluated retrospectively. Patients who had received radioactive iodine treatment and external irradiation treatment in the neck region and who had had thyroid surgery previously were not included in the study. Results While accompanying thyroid nodule was present in 177 (33.6%) of 526 Graves’ patients, thyroid nodule was absent in 349 (66.4%) patients. Forty-two (8%) patients had thyroid cancer. The rate of thyroid cancer was 5.4% (n = 19) in the Graves’ patients who had no nodule, whereas it was 13% (n = 23) in the patients who had nodule. The risk of thyroid cancer increased significantly in presence of nodule (p = 0.003). Three patients had recurrence. No patient had distant metastasis. No patient died during the follow-up period. Conclusions Especially Graves’ patients who have been decided to be followed up should be evaluated carefully during the follow-up in terms of thyroid cancer which may accompany. Arq Bras Endocrinol Metab. 2014;58(9):933-8

scholarly journals Differentiated thyroid carcinoma in previously manifested autoimmune thyroid disease

2005 ◽  
Vol 133 (Suppl. 1) ◽  
pp. 74-76 ◽  
Author(s):  
Jasmina Ciric ◽  
Biljana Beleslin-Nedeljkovic
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma ◽  
Graves Disease ◽  
Autoimmune Thyroid Diseases ◽  
Carcinogenic Effect ◽  
Thyroid Carcinomas ◽  
Autoimmune Thyroid

Autoimmune thyroid diseases are frequently associated with differentiated thyroid carcinomas. The role of autoimmune phenomena in the origin and clinical course of coexisting papillary and follicular carcinomas is still controversial. In Graves? patients, the prevalence of palpable thyroid nodules is 15.8%, and by using ultrasonography, the prevalence increases to 33.6%. Since the malignancy rate of palpable thyroid nodules in Graves? patients is 16.9%, approximately threefold higher than in general population, it seems that a thyroid nodule diagnosed in Graves? patients is at higher risk for malignancy. In addition, radioiodine therapy for Graves? disease was found to be associated with increased incidence of thyroid cancer in some studies. These studies however, were not able to confirm the carcinogenic effect of radioiodine therapy since the late growth of occult carcinomas could not be excluded. The frequency of the association of Hashimoto?s thyroiditis and differentiated thyroid carcinomas is approximately 30%. The presence of coexistent Hashimoto?s thyroiditis does not affect the diagnostic evaluation and management of papillary thyroid cancer. The frequent presentation of differentiated thyroid carcinomas in Graves? disease and Hashimoto?s thyroiditis opens the possibility that some mutual pathogenethic mechanisms might be involved in the development of these diseases.

Thyroiditis, Goiter, Thyroid Nodules, and Thyroid Cancer

2020 ◽  
Author(s):  
Paul W. Ladenson
Keyword(s):  
Differential Diagnosis ◽  
Thyroid Cancer ◽  
Celiac Disease ◽  
Thyroid Nodules ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Munchausen Syndrome ◽  
Life Threatening ◽  
Almost All ◽  
Key Words Hypothyroidism

Thyroid disorders are the most common endocrine conditions encountered in clinical practice. Persons of either sex and any age can be affected, although almost all forms of thyroid disease are more frequent in women than in men, and many thyroid ailments increase in incidence with age. The presentation of thyroid conditions can range from clinically obvious to clinically silent. Their consequences can be widespread and serious, even life-threatening. With proper testing, the diagnosis and differential diagnosis can be established with certainty, and effective treatments can be instituted for almost all patients. This review contains 1 figure, 7 tables, and 31 references. Key Words: Hypothyroidism, Thyrotoxicosis, Thyrotropin, celiac disease, vitiligo, pernicious anemia, Sjögren syndrome, Graves disease, Munchausen syndrome

Thyroiditis, Goiter, Thyroid Nodules, and Thyroid Cancer

2020 ◽  
Author(s):  
Paul W. Ladenson
Keyword(s):  
Differential Diagnosis ◽  
Thyroid Cancer ◽  
Celiac Disease ◽  
Thyroid Nodules ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Munchausen Syndrome ◽  
Life Threatening ◽  
Almost All ◽  
Key Words Hypothyroidism

Thyroid disorders are the most common endocrine conditions encountered in clinical practice. Persons of either sex and any age can be affected, although almost all forms of thyroid disease are more frequent in women than in men, and many thyroid ailments increase in incidence with age. The presentation of thyroid conditions can range from clinically obvious to clinically silent. Their consequences can be widespread and serious, even life-threatening. With proper testing, the diagnosis and differential diagnosis can be established with certainty, and effective treatments can be instituted for almost all patients. This review contains 1 figure, 7 tables, and 31 references. Key Words: Hypothyroidism, Thyrotoxicosis, Thyrotropin, celiac disease, vitiligo, pernicious anemia, Sjögren syndrome, Graves disease, Munchausen syndrome

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