scholarly journals Induction of specific transplantation immunity by oral immunization with allogeneic cells

Immunology ◽  
2000 ◽  
Vol 101 (3) ◽  
pp. 404-411 ◽  
Author(s):  
V. Holan ◽  
A. Zajicova ◽  
M. Krulova ◽  
J. Plskova ◽  
J. Fric ◽  
...  
Keyword(s):  
Oral Immunization ◽  
Transplantation Immunity

METHOD OF DETERMINING THE IMMUNOGENIC ACTIVITY OF LIVE VACCINE AGAINST RABIES IN WILD ANIMALS IN MICE

2020 ◽  
pp. 53-57
Author(s):  
V. A. Babak ◽  
A. A. Gusev ◽  
I. A. Puntus ◽  
A. S. Smailova
Keyword(s):  
Infection Control ◽  
Rabies Virus ◽  
Experimental Infection ◽  
Oral Immunization ◽  
Live Vaccine ◽  
Wild Animals ◽  
Method Of Evaluation

The results of alternative studies on the immunogenic activity of live rabies vaccines for oral immunization of wild carnivorous animals are presented. The method of evaluation of immunogenicity using a model of oral immunization in mice with experimental infection control rabies virus CVS in the dose of 10–100 MLD50/0,03 ml. Once entered immunizing dose for white mice, weighing 12–14 g were 56.200 MLD50, the titers of VNA ranged from 1:6 to 1:16 (3,0–4,0 log2) and above.

scholarly journals Biologia futura: embryo–maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation

2021 ◽  
Author(s):  
Julia Szekeres-Bartho ◽  
Timea Csabai ◽  
Eva Gorgey
Keyword(s):  
Extracellular Vesicles ◽  
Cell Function ◽  
Nk Cell ◽  
Immune Functions ◽  
Transplantation Immunity ◽  
Blocking Factor ◽  
Cytokine Balance ◽  
Favourable Environment ◽  
Normal Gestation

AbstractPaternal antigens expressed by the foetus are recognized as foreign. Therefore,—according to the rules of transplantation immunity—the foetus ought to be “rejected”. However, during normal gestation, maternal immune functions are re-adjusted, in order to create a favourable environment for the developing foetus. Some of the mechanisms that contribute to the altered immunological environment, for example, the cytokine balance and NK cell function, with special emphasis on the role of progesterone and the progesterone-induced blocking factor (PIBF) will be reviewed.

Oral Immunization

BMJ ◽  
1948 ◽  
Vol 2 (4585) ◽  
pp. 906-906
Author(s):  
L. P. Garrod
Keyword(s):  
Oral Immunization

scholarly journals Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg

2005 ◽  
Vol 86 (3) ◽  
pp. 601-610 ◽  
Author(s):  
Xiao-Wen He ◽  
Fang Wang ◽  
Lei Jiang ◽  
Jun Li ◽  
Shan-kui Liu ◽  
...  
Keyword(s):  
Single Dose ◽  
Plasmid Dna ◽  
Dna Vaccines ◽  
Oral Immunization ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Pcr Analysis ◽  
Target Antigen ◽  
Dna Encoding ◽  
Plga Microparticles

The purpose of this work was to assess the ability of plasmid DNA encoding hepatitis B virus (HBV) HBsAg encapsulated in poly(dl-lactide-co-glycolic acid) (PLGA) microparticles to induce local and systemic HBsAg-specific immunity following a single dose of oral immunization. RT-PCR analysis demonstrated prolonged transcription of plasmid DNA, consistent with the sustained expression and presentation of target antigen observed by confocal laser scanning microscopy, in gut-associated lymphocyte tissue (GALT) from mice immunized orally with plasmid DNA encapsulated into PLGA microparticles. Oral administration of PLGA-DNA microparticles induced a long-lasting and stable antigen-specific antibody response, both serum total antibody and intestinal IgA, in BALB/c mice. Mice immunized orally exhibited antigen-specific gamma interferon production and cytotoxic T lymphocyte responses in spleen and GALT after restimulation in vitro with HBsAg or tumour cells stably expressing HBsAg. In contrast, naked DNA vaccines given by intramuscular injection induced only systemic cellular and humoral responses to HBsAg, which were much lower than the responses elicited by oral DNA encapsulated in PLGA microparticles at equivalent doses. The results are encouraging with regard to obtaining good compliance and vaccination coverage with candidate plasmid DNA vaccines, especially in developing countries.

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