Large artery mechanical properties correlate with severity of coronary artery disease

2000 ◽  
Vol 9 (3) ◽  
pp. A155
Author(s):  
T.K. Waddell ◽  
T.L. Medley ◽  
C.D. Gatzka ◽  
J.D. Cameron ◽  
A.M. Dart ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Large Artery ◽  
Artery Disease

scholarly journals The relationship between mechanical properties of carotid artery and coronary artery disease

2011 ◽  
Vol 13 (7) ◽  
pp. 568-573 ◽  
Author(s):  
S.-A. Kim ◽  
S.-M. Park ◽  
M.-N. Kim ◽  
Y.-H. Kim ◽  
D.-H. Cho ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Artery Disease ◽  
The Relationship

scholarly journals Coronary Artery Disease in Patients Presenting With Acute Ischemic Stroke or Transient Ischemic Attack and Elevated Troponin Levels

2022 ◽  
Vol 12 ◽  
Author(s):  
Mathieu Kruska ◽  
Anna Kolb ◽  
Christian Fastner ◽  
Iris Mildenberger ◽  
Svetlana Hetjens ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Ischemic Stroke ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Transient Ischemic Attack ◽  
Large Artery ◽  
Elevated Troponin ◽  
Stroke Patients ◽  
Artery Disease ◽  
Ischemic Attack

Background: There is little information concerning the invasive coronary angiography (ICA) findings of patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) with elevated troponin levels and suspected myocardial infarction (MI). This study analyzed patient characteristics associated with ICA outcomes.Methods: A total of 8,322 patients with AIS or TIA, treated between March 2010 and May 2020, were retrospectively screened for elevated serum troponin I at hospital admission. Patients in whom ICA was performed, due to suspected type 1 MI based on symptoms, echocardiography, and ECG, were categorized according to ICA results (non-obstructive coronary artery disease (CAD): ≥1 stenosis ≥50% but no stenosis ≥80%; obstructive CAD: any stenosis ≥80% or hemodynamically relevant stenosis assessed by FFR/iwFR).Results: Elevated troponin levels were detected in 2,205 (22.5%) patients, of whom 123 (5.6%) underwent ICA (mean age 71 ± 12 years; 67% male). CAD was present in 98 (80%) patients, of whom 51 (41%) were diagnosed with obstructive CAD. Thus, ICA findings of obstructive CAD accounted for 2.3% of patients with troponin elevation and 0.6% of all stroke patients. The clinical hallmarks of myocardial ischemia, including angina pectoris (31 vs. 15%, p < 0.05) and regional wall motion abnormalities (49 vs. 32%, p = 0.07), and increased cardiovascular risk indicated obstructive CAD. While there was no association between lesion site or stroke severity and ICA findings, causal large-artery atherosclerosis was significantly more common in patients with obstructive coronary disease (p < 0.05).Conclusion: The rate of obstructive CAD in patients with stroke or TIA and elevated troponin levels with suspected concomitant type I MI is low. The cumulation of several cardiovascular risk factors and clinical signs of MI were predictive. AIS patients with large-artery atherosclerosis and elevated troponin may represent an especially vulnerable subgroup of stroke patients with risk for obstructive CAD.

Large artery compliance predicts time to ischemia during treadmill testing in coronary artery disease patients

2000 ◽  
Vol 9 (3) ◽  
pp. A128 ◽  
Author(s):  
B.A. Kingwell ◽  
T.L. Medley ◽  
T.K. Waddell ◽  
J.D. Cameron ◽  
G.L. Jennings ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Large Artery ◽  
Treadmill Testing ◽  
Artery Disease

scholarly journals Predictors and Functional Outcomes of Fast, Intermediate, and Slow Progression Among Patients With Acute Ischemic Stroke

Stroke ◽  
2020 ◽  
Vol 51 (8) ◽  
pp. 2553-2557 ◽  
Author(s):  
Woo-Keun Seo ◽  
David S. Liebeskind ◽  
Bryan Yoo ◽  
Latisha Sharma ◽  
Reza Jahan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Ischemic Stroke ◽  
Coronary Artery ◽  
Functional Outcomes ◽  
Artery Occlusion ◽  
Large Artery ◽  
Anterior Circulation ◽  
Endovascular Thrombectomy ◽  
Ischemic Core ◽  
Artery Disease

Background and Purpose: We aimed to delineate the determinants of the initial speed of infarct progression and the association of speed of infarct progression (SIP) with procedural and functional outcomes. Methods: From a prospectively maintained stroke center registry, consecutive anterior circulation ischemic stroke patients with large artery occlusion, National Institutes of Health Stroke Scale score ≥4, and multimodal vessel, ischemic core, and tissue-at-risk imaging within 24 hours of onset were included. Initial SIP was calculated as ischemic core volume at first imaging divided by the time from stroke onset to imaging. Results: Among the 88 patients, SIP was median 2.2 cc/h (interquartile range, 0–8.7), ranging most widely within the first 6 hours after onset. Faster SIP was positively independently associated with a low collateral score (odds ratio [OR], 3.30 [95% CI, 1.25–10.49]) and arrival by emergency medical services (OR, 3.34 [95% CI, 1.06–10.49]) and negatively associated with prior ischemic stroke (OR, 0.12 [95% CI, 0.03–0.50]) and coronary artery disease (OR, 0.32 [95% CI, 0.10–1.00]). Among the 67 patients who underwent endovascular thrombectomy, slower SIP was associated with a shift to reduced levels of disability at discharge (OR, 3.26 [95% CI, 1.02–10.45]), increased substantial reperfusion by thrombectomy (OR, 8.30 [95% CI, 0.97–70.87]), and reduced radiological hemorrhagic transformation (OR, 0.34 [95% CI, 0.12–0.94]). Conclusions: Slower SIP is associated with a high collateral score, prior ischemic stroke, and coronary artery disease, supporting roles for both collateral robustness and ischemic preconditioning in fostering tissue resilience to ischemia. Among patients undergoing endovascular thrombectomy, the speed of infarct progression is a major determinant of clinical outcome.

scholarly journals Large artery stiffness predicts ischemic threshold in patients with coronary artery disease

2002 ◽  
Vol 40 (4) ◽  
pp. 773-779 ◽  
Author(s):  
Bronwyn A Kingwell ◽  
Tamara K Waddell ◽  
Tanya L Medley ◽  
James D Cameron ◽  
Anthony M Dart
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Large Artery ◽  
Artery Stiffness ◽  
Artery Disease

scholarly journals Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

2020 ◽  
Author(s):  
Michael G. Levin ◽  
Derek Klarin ◽  
Themistocles L. Assimes ◽  
Matthew S. Freiberg ◽  
Erik Ingelsson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Artery Disease ◽  
Mendelian Randomization ◽  
Large Artery ◽  
Peripheral Artery ◽  
Genetic Liability ◽  
Genome Wide ◽  
Artery Disease

ABSTRACTImportanceSmoking is associated with atherosclerotic cardiovascular disease, but the relative contribution to each subtype (coronary artery disease [CAD], peripheral artery disease [PAD], and large-artery stroke) remains less well understood.ObjectiveTo determine the effect of smoking on risk of coronary artery disease, peripheral artery disease, and large-artery stroke.DesignMendelian randomization study using summary statistics from genome-wide associations of smoking (up to 462,690 individuals), coronary artery disease (up to 60,801 cases, 123,504 controls), peripheral artery disease (up to 24,009 cases, 150,983 controls), and large-artery stroke (up to 4,373 cases, 406,111 controls)SettingPopulation-based study of primarily European-ancestry individualsParticipantsParticipants in genome-wide association studies of smoking, coronary artery disease, peripheral artery disease, and stroke.ExposuresGenetic liability to smoking defined by lifetime smoking index: an integrated measure of smoking status, age at initiation, age at cessation, number of cigarettes smoked per day, and declining effect of smoking on health outcomes).Main Outcome MeasureRisk of coronary artery disease, peripheral artery disease, and large-artery stroke.ResultsGenetic liability to smoking was associated with increased risk of PAD (OR 2.13; 95% CI 1.78-2.56; P = 3.6 × 10−16), CAD (OR 1.48; 95% CI 1.25-1.75; P = 4.4 × 10−6), and stroke (OR 1.4; 95% CI 1.02-1.92; P = 0.036). Risk of PAD in smokers was greater than risk of large-artery stroke (pdifference = 0.025) or CAD (pdifference = 0.0041). The effect of smoking on ASCVD remained independent from the effects of smoking on traditional cardiovascular risk factors.Conclusions and RelevanceGenetic liability to smoking is a strong, causal risk factor for CAD, PAD, and stroke, although the effect of smoking is strongest for PAD. The effect of smoking is independent of traditional cardiovascular risk factors.

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