Effect of oral administration of high-dose nitric oxide donor l-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study

2001 ◽  
Vol 83 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Chen ◽  
Wollman ◽  
Chernichovsky ◽  
Iaina ◽  
Sofer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Erectile Dysfunction ◽  
Oral Administration ◽  
Nitric Oxide Donor ◽  
Controlled Study ◽  
High Dose ◽  
Double Blind

Transdermal Nitroglycerine in the Management of Pain Associated with Primary Dysmenorrhoea: A Multinational Pilot Study

1997 ◽  
Vol 25 (1) ◽  
pp. 41-44 ◽  
Author(s):  
O Ré ◽  
Keyword(s):  
Nitric Oxide ◽  
Pain Relief ◽  
Muscle Relaxation ◽  
Nitric Oxide Donor ◽  
Controlled Study ◽  
Smooth Muscle Relaxation ◽  
Uterine Contractility ◽  
Double Blind ◽  
Patch Application ◽  
Endogenous Nitric Oxide

Endogenous nitric oxide mediates smooth-muscle relaxation with subsequent vasodilatation in the vascular, pulmonary, gastrointestinal and genitourinary tissues. Transdermal nitroglycerine (a nitric oxide donor) has been found effective in inhibiting uterine contractility during premature labour. Sixty-five women with histories of moderate-to-severe pain associated with menses were treated with nitroglycerine patches that delivered 0.2 or 0.1 mg/h. Patches were applied as necessary during the first 3 days of the menstrual cycle for up to three consecutive cycles. Pain intensity was assessed at baseline and at 30 min and at 1, 2 and 4 h after patch application. Most patients obtained pain relief with the first dose of the first day. Pain relief was satisfactory to excellent in 90% of the patients. Headache was reported by 20% of the patients, most often in patients using two consecutive patches. A randomized, double-blind, placebo-controlled study is underway in an attempt to confirm the above findings.

Role of nitric oxide signaling in the antidepressant mechanism of action of ketamine: A randomized controlled trial

2021 ◽  
Vol 35 (2) ◽  
pp. 124-127
Author(s):  
Laura Bevilacqua ◽  
Alex Charney ◽  
Charlotte R Pierce ◽  
Samantha M Richards ◽  
Manish K Jha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Sodium Nitroprusside ◽  
Mechanism Of Action ◽  
Controlled Trial ◽  
Nitric Oxide Donor ◽  
Controlled Study ◽  
Primary Role ◽  
Double Blind ◽  
Nitric Oxide Signaling ◽  
Antidepressant Effects

Ketamine is an N-methyl-D-aspartate receptor antagonist with rapid antidepressant effects. Studies suggest that inhibition of nitric oxide synthesis plays a role in the mechanism of action of ketamine. This randomized, placebo-controlled study investigated whether co-administration of sodium nitroprusside, a nitric oxide donor, compared to placebo, would attenuate the antidepressant and dissociative effects of ketamine. Sixteen ketamine responders were randomized to a double-blind infusion of ketamine co-administered with placebo or sodium nitroprusside. Our findings show no difference between the two conditions suggesting that the nitric oxide pathway may not play a primary role in ketamine’s antidepressant or dissociative effects. The study is registered at clinicaltrials.gov (NCT03102736).

A novel anti-ischemic nitric oxide donor inhibits thrombosis without modifying haemodynamic parameters

2004 ◽  
Vol 91 (05) ◽  
pp. 1035-1043 ◽  
Author(s):  
Gemma Vilahur ◽  
Estefania Segalés ◽  
Laura Casaní ◽  
Lina Badimon
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Oral Administration ◽  
Vessel Wall ◽  
Liver Enzymes ◽  
Nitric Oxide Donor ◽  
Organic Nitrate ◽  
High Dose ◽  
Dependent Manner ◽  
Damaged Vessel

SummaryPlatelets are involved in the clinical presentations of ischemic heart disease. Our objective was to study the antithrombotic effects of a new nitric oxide donor (LA419), a neutral sugar organic nitrate with a protected thiol group in its molecular structure. Animals were randomly distributed in three groups: I) oral administration of LA419 (0.9-1.8-3.6-5 mg/kg/d, 10 days); II) oral administration of standard IS-5-MN (0.9-1.8 mg/kg/d, 10 days); III) non-treated group (control). In catheterized pigs, thrombosis was studied under controlled rheological condi- tions by radioisotopic evaluation of deposited platelets on damaged vessel wall, placed in an extracorporeal perfusion chamber. Changes in blood pressure, heart rate, and platelet aggregation were evaluated. Results have shown that LA419 significantly decreased thrombus formation according to the degree of vascular damage, and shear rate conditions in a dose- dependent manner (p<0.005), without significant modifications on blood pressure and/or elevation of liver enzymes. In contrast, IS-5-MN only showed a significant reduction on plate- let deposition at the high dose, that was associated to hypoten- sion and elevation of liver enzymes. Therefore, we conclude that this new anti-ischemic NO-donor (NOd) LA419 that inhibits platelet function without modifying blood pressure may be a highly efficacious strategy to passivate platelet activation induced by a damaged vessel wall.

Preliminary Results with the Nitric Oxide Donor Linsidomine Chlorhydrate in the Treatment of Human Erectile Dysfunction

1992 ◽  
Vol 148 (5 Part 1) ◽  
pp. 1437-1440 ◽  
Author(s):  
Christian G. Stief ◽  
Fredrik Holmquist ◽  
Mohamad Djamilian ◽  
Helmut Krah ◽  
Karl-Erik Andersson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Erectile Dysfunction ◽  
Nitric Oxide Donor ◽  
Preliminary Results

High-dose adenosine infusion provokes oscillations of chest pain without correlation to opioid modulation: A double-blind controlled study

2004 ◽  
Vol 5 (9) ◽  
pp. 469-475 ◽  
Author(s):  
Bita Sadigh-Lindell ◽  
Christer Sylvén ◽  
Margareta Berglund ◽  
Björn E. Eriksson
Keyword(s):  
Chest Pain ◽  
Adenosine Infusion ◽  
Controlled Study ◽  
High Dose ◽  
Double Blind

Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

2017 ◽  
Vol 31 (10) ◽  
pp. 1374-1376
Author(s):  
Jack H Wilson ◽  
Amy H Criss ◽  
Sean A Spangler ◽  
Katherine Walukevich ◽  
Sandra Hewett
Keyword(s):  
Young Adults ◽  
Healthy Adult ◽  
Adult Population ◽  
Critical Role ◽  
Random Order ◽  
Controlled Study ◽  
High Dose ◽  
Short Term ◽  
Double Blind ◽  
Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

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