Chapter 9 Species Survival Probabilities’ Scenarios

Summary The process of cytodifferentiation in spermatogenesis is governed by a unique genetic and molecular programme. In this context, accurate ‘tuning’ of the regulatory mechanisms involved in germ cells differentiation is required, as any error could have dramatic consequences on species survival and maintenance. To study the processes that govern the spatial–temporal expression of genes, as well as analyse transmission of epigenetic information to descendants, an integrated approach of genetics, biochemistry and cytology data is necessary. As information in the literature on interplay between DNA methylation and histone H3 lysine 4 trimethylation (H3K4me3) in the advanced stages of murine spermatogenesis is still scarce, we investigated the effect of a DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, at the cytological level using immunocytochemistry methodology. Our results revealed a particular distribution of H3K4me3 during sperm cell differentiation and highlighted an important role for regulation of DNA methylation in controlling histone methylation and chromatin remodelling during spermatogenesis.

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Center for Species Survival Brazil

Oryx ◽

10.1017/s0030605321000557 ◽

2021 ◽

Vol 55 (4) ◽

pp. 496-496

Author(s):

Fabiana Lopes Rocha ◽

Eugenia Cordero-Schmidt ◽

Rosana Subirá ◽

Carmel Croukamp ◽

Leandro Jerusalinsky ◽

...

Keyword(s):

Species Survival

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SurvCNN: A Discrete Time-to-Event Cancer Survival Estimation Framework Using Image Representations of Omics Data

Cancers ◽

10.3390/cancers13133106 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3106

Author(s):

Yogesh Kalakoti ◽

Shashank Yadav ◽

Durai Sundar

Keyword(s):

Discrete Time ◽

Cancer Survival ◽

Performance Metrics ◽

Downstream Processing ◽

Cancer Prognosis ◽

Precision Oncology ◽

Omics Data ◽

Time Model ◽

Survival Probabilities ◽

Image Representations

The utility of multi-omics in personalized therapy and cancer survival analysis has been debated and demonstrated extensively in the recent past. Most of the current methods still suffer from data constraints such as high-dimensionality, unexplained interdependence, and subpar integration methods. Here, we propose SurvCNN, an alternative approach to process multi-omics data with robust computer vision architectures, to predict cancer prognosis for Lung Adenocarcinoma patients. Numerical multi-omics data were transformed into their image representations and fed into a Convolutional Neural network with a discrete-time model to predict survival probabilities. The framework also dichotomized patients into risk subgroups based on their survival probabilities over time. SurvCNN was evaluated on multiple performance metrics and outperformed existing methods with a high degree of confidence. Moreover, comprehensive insights into the relative performance of various combinations of omics datasets were probed. Critical biological processes, pathways and cell types identified from downstream processing of differentially expressed genes suggested that the framework could elucidate elements detrimental to a patient’s survival. Such integrative models with high predictive power would have a significant impact and utility in precision oncology.

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Radiation Therapy for Stage I Primary Orbital Non-Hodgkin's Lymphomas

Tumori Journal ◽

10.1177/030089169708300509 ◽

1997 ◽

Vol 83 (5) ◽

pp. 822-825 ◽

Cited By ~ 9

Author(s):

Haldun Şükrü Erkal ◽

Meltem Serin ◽

Serpil Dizbay Sak ◽

Ahmet Çakmak

Keyword(s):

Radiation Therapy ◽

Combination Chemotherapy ◽

Disease Free Survival ◽

Stage I ◽

Entire Group ◽

Low Grade ◽

Intermediate Grade ◽

Chop Regimen ◽

Survival Probabilities ◽

Hodgkin's Lymphomas

Aims and Background The orbit is an uncommon primary site for non-Hodgkin's lymphomas (NHL), and it accounts for less than 1% of all sites of primary presentations. We report the experience of the Department of Radiation Oncology at Ankara University Faculty of Medicine with radiation therapy in treatment of patients with stage I primary orbital NHL. Methods From February 1978 through August 1993, 14 patients with stage I primary orbital NHL were treated with radiation therapy. According to the Working Formulation classification, 8 patients had low-grade and 6 had intermediate-grade lymphomas. The most commonly used radiation therapy technique was a single anterior field with a Cobalt-60 unit, delivering 40 Gy in 2 Gy daily fractions. Two patients with intermediate-grade lymphomas received the CHOP regimen following radiation therapy. Results Follow-up ranged from 0.8 to 18.3 years (median, 10.3 years). Local control was achieved in all patients. Two patients with low-grade lymphomas relapsed locally and were successfully salvaged with radiation therapy. Three patients with intermediate-grade lymphomas failed systemically. Salvage therapy consisted of combination chemotherapy for 2 of them but was unsuccessful. Overall survival probabilities at 2, 5 and 10 years were 78.6%, 61.1% and 52.4%, respectively, for the entire group of 14 patients. Overall, cause-specific and disease-free survival probabilities were higher for patients with low-grade lymphomas than for those with intermediate-grade lymphomas (P = 0.03, P = 0.03 and P = 0.06, respectively). Cataracts were observed in 9 and lacrimal disorders in 4 patients. Conclusions The study suggests that among stage I primary orbital NHL, low-grade lymphomas could be treated with radiation therapy alone, whereas combination chemotherapy could accompany radiation therapy for intermediate-grade lymphomas.

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Survival to hatching of fishes in sulfate-saline waters, Devils Lake, North Dakota

Canadian Journal of Fisheries and Aquatic Sciences ◽

10.1139/f95-047 ◽

1995 ◽

Vol 52 (3) ◽

pp. 464-469 ◽

Cited By ~ 9

Author(s):

Todd M. Koel ◽

John J. Peterka

Keyword(s):

North Dakota ◽

Sodium Sulfate ◽

Yellow Perch ◽

Hatching Success ◽

Perca Flavescens ◽

White Sucker ◽

Catostomus Commersoni ◽

Devils Lake ◽

Common Carp Cyprinus Carpio ◽

Species Survival

Laboratory-based bioassays were conducted to determine concentrations of sodium-sulfate type salinities that limit the hatching success of several fish species. Survival to hatching (SH) was significantly lower (P < 0.05) in sodium-sulfate type waters from Devils Lake, North Dakota, of ≥ 2400 mg/L total dissolved solids (TDS) than in fresh water of 200 mg/L. In waters of 200, 1150, 2400, 4250, and 6350 mg/L TDS, walleye (Stizostedion vitreum) SH was 41, 38, 7, 1, and 0%; northern pike (Esox lucius) SH was 92, 68, 33, 2, and 0%; yellow perch (Perca flavescens) SH was 88, 70, 73, 0, and 0%; white sucker (Catostomus commersoni) SH was 87, 95, 66, 0, and 0%; common carp (Cyprinus carpio) SH was 71, 69, 49, 63, and 25%.

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