Abstract
Background:Retrospectively register the clinical data of secondary hyperparathyroidism(SHPT)patients who received surgical treatment, summarize the postoperative calcium regulation scheme in details and analyze statistically related factors for guiding clinical early intervention and evaluating prognosis.Methods: Review the clinical data of 136 patients with chronic renal failure in uremic stage from Jinzhou Central Hospital and the Second Affiliated Hospital of Dalian Medical University, who received dialysis treatment for a long time and finally diagnosed as secondary hyperparathyroidism, from Jan 2017 to Dec 2019, were accepted different operations to treat hyperparathyroidism, were given corresponding calcium regulation therapy to avoid serious complicationswere, and were divided into the observation group and the control group according to the postoperative calcium regulation time of ≤7days and > 7days, which is defined as the time from the day of operation until the day when the patients have stable blood calcium levels and no obvious discomfort symptoms.Results: The difference between the two groups was statistically significant (P<0.001); Compared with the control group, the observation group were elder(54.01±9.215; P<0.01), shorter preoperative dialysis time (5.05±2.855; P<0.01); significant difference in operation mode (P=0.026); positive preoperative oral calcium(c2=9.941, P=0.002), higher preoperative calcium value (t=4.795; P<0.001), lower preoperative Parathyroid Hormone(PTH) value (t=6.327; P<0.001), lower preoperative Alkaline phosphatase(ALP) value (t=3.527; P=0.001); Multivariate analysis showed that age, preoperative calcium value, preoperative PTH value and preoperative ALP value were independent risk factors for postoperative calcium regulation therapy. Those factors, Gender, preoperative dialysis mode, complications, preoperative Hemoglobin(HB) value, were not related to postoperative calcium regulation. There was no significant difference between the two groups (P>0.05).Conclusion: Effective postoperative calcium regulation can maintain a stable level of blood calcium in the patients with secondary hyperparathyroidism, so as to avoid the occurrence of severe hypocalcemia.