scholarly journals Advanced Process Control to Minimize Disturbance in Gas Processing Facility (GPF)

2020 ◽  
Vol 190 ◽  
pp. 00037
Author(s):  
Safira Firdaus Mujiyanti ◽  
Totok Ruki Biyanto
Keyword(s):  
Process Control ◽  
Mass Flow ◽  
Control Process ◽  
Gas Treatment ◽  
Advanced Process Control ◽  
Gas Processing ◽  
Flow Response ◽  
Separation Of Gases ◽  
Plant Modelling ◽  
The Stability

For the gas treatment process, the process that occurs is separating the gas from the components of H2S, CO2, and H2O. The separation of gases from these components uses the aid of Amine fluid and TEG fluid. The unit that important in this process are Amine and TEG Contactor. To be able to separate the three components from the gas, the mass flow rate of Amine and TEG must be controlled so that the processing can work optimally. In reality in the field, the input of this process from the well is not always steady. So, this condition becomes a disturbance from the control process. The solution to minimize the disturbance of process with Advanced Process Control (APC). Therefore, this research will design APC on Amine and TEG Contactor to improve the stability of the mass flow response of Amine and TEG. In designing APC, the plant model is required first. Plant modelling obtained with software HYSYS and validated with MATLAB. The result shows the RMSE value below 5 %. The result proved to be able to make the process more stable from before design proven by slurries settling time, steadystate errors and maximum overshoot.

scholarly journals Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

Processes ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 172
Author(s):  
Heribert Helgers ◽  
Axel Schmidt ◽  
Lara Julia Lohmann ◽  
Florian Lukas Vetter ◽  
Alex Juckers ◽  
...  
Keyword(s):  
Process Control ◽  
Product Quality ◽  
Process Development ◽  
Process Analytical Technology ◽  
Control Process ◽  
Continuous Manufacturing ◽  
Two Phase ◽  
Advanced Process Control ◽  
Vis Spectroscopy ◽  
Analytical Technology

Continuous manufacturing opens up new operation windows with improved product quality in contrast to documented lot deviations in batch or fed-batch operations. A more sophisticated process control strategy is needed to adjust operation parameters and keep product quality constant during long-term operations. In the present study, the applicability of a combination of spectroscopic methods was evaluated to enable Advanced Process Control (APC) in continuous manufacturing by Process Analytical Technology (PAT). In upstream processing (USP) and aqueous two-phase extraction (ATPE), Raman-, Fourier-transformed infrared (FTIR), fluorescence- and ultraviolet/visible- (UV/Vis) spectroscopy have been successfully applied for titer and purity prediction. Raman spectroscopy was the most versatile and robust method in USP, ATPE, and precipitation and is therefore recommended as primary PAT. In later process stages, the combination of UV/Vis and fluorescence spectroscopy was able to overcome difficulties in titer and purity prediction induced by overlapping side component spectra. Based on the developed spectroscopic predictions, dynamic control of unit operations was demonstrated in sophisticated simulation studies. A PAT development workflow for holistic process development was proposed.

Increasing revenue and reducing cost through the use of advanced process control technology in the sugar industry

2016 ◽  
pp. 620-624
Author(s):  
Scott Kahre
Keyword(s):  
Process Control ◽  
Sugar Industry ◽  
Operating Cost ◽  
Control Technology ◽  
Advanced Process Control ◽  
Output Controller ◽  
Complex Processes ◽  
Unit Operations ◽  
Sugar Unit ◽  
Optimum Cost

Advanced process control technology can provide sugar processors the ability to realize major revenue enhancements and/or operating cost reductions with low initial investment. One technology in particular, model predictive control (MPC), holds the potential to increase production, reduce energy costs, and reduce quality variability in a wide variety of major sugar unit operations. These include centrifugal stations, pulp dryers, extractors, diffusers, mills, evaporating crystallizers, juice purification, and more. Simple payback periods as low as two months are projected. As a PC-based add-on to existing distributed control systems (DCS) or programmable logic controller (PLC) systems, MPC acts as a multi-input, multi-output controller, utilizing predictive process response models and optimization functions to control complex processes to their optimum cost and quality constraints.

scholarly journals InsP7is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

2020 ◽  
Vol 117 (32) ◽  
pp. 19245-19253 ◽  
Author(s):  
Soumyadip Sahu ◽  
Zhenzhen Wang ◽  
Xinfu Jiao ◽  
Chunfang Gu ◽  
Nikolaus Jork ◽  
...  
Keyword(s):  
Stress Responses ◽  
Messenger Rna ◽  
Control Process ◽  
Stem Cell Differentiation ◽  
Wild Type ◽  
Inositol Pyrophosphate ◽  
Body Dynamics ◽  
Processing Body ◽  
The Stability

Regulation of enzymatic 5′ decapping of messenger RNA (mRNA), which normally commits transcripts to their destruction, has the capacity to dynamically reshape the transcriptome. For example, protection from 5′ decapping promotes accumulation of mRNAs into processing (P) bodies—membraneless, biomolecular condensates. Such compartmentalization of mRNAs temporarily removes them from the translatable pool; these repressed transcripts are stabilized and stored until P-body dissolution permits transcript reentry into the cytosol. Here, we describe regulation of mRNA stability and P-body dynamics by the inositol pyrophosphate signaling molecule 5-InsP7(5-diphosphoinositol pentakisphosphate). First, we demonstrate 5-InsP7inhibits decapping by recombinant NUDT3 (Nudix [nucleoside diphosphate linked moiety X]-type hydrolase 3) in vitro. Next, in intact HEK293 and HCT116 cells, we monitored the stability of a cadre of NUDT3 mRNA substrates following CRISPR-Cas9 knockout ofPPIP5Ks(diphosphoinositol pentakisphosphate 5-kinases type 1 and 2, i.e.,PPIP5KKO), which elevates cellular 5-InsP7levels by two- to threefold (i.e., within the physiological rheostatic range). ThePPIP5KKO cells exhibited elevated levels of NUDT3 mRNA substrates and increased P-body abundance. Pharmacological and genetic attenuation of 5-InsP7synthesis in the KO background reverted both NUDT3 mRNA substrate levels and P-body counts to those of wild-type cells. Furthermore, liposomal delivery of a metabolically resistant 5-InsP7analog into wild-type cells elevated levels of NUDT3 mRNA substrates and raised P-body abundance. In the context that cellular 5-InsP7levels normally fluctuate in response to changes in the bioenergetic environment, regulation of mRNA structure by this inositol pyrophosphate represents an epitranscriptomic control process. The associated impact on P-body dynamics has relevance to regulation of stem cell differentiation, stress responses, and, potentially, amelioration of neurodegenerative diseases and aging.

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