Analysis of staged treatment and some socio-hygienic and biological factors for the onset and course of gastric ulcer and duodenal ulcer

The aim of the study was to study the frequency and nature of episodes of heartburn and bloating in patients with duodenal and gastric ulcers in the Georgian population, considering the histomorphological and morphometric changes of the gastric mucosa and the parameters of gastric secretion. At the same time, we were interested in analyzing patients' anamnesis before being hospitalized for the last 2 months. The analysis of the material showed that incidence of heartburn episodes in the Georgian population is clearly higher in patients with peptic ulcer disease 12 - (79.9%) than in patients with gastric ulcer (9 - 31.9%). Episodes of heartburn in these patients are characterized not only by increasing of rate (more than 50 episodes), both day and night, but the intensity and duration (which is due to abnormal gastroesophageal reflux). This is a high risk for the occurrence of heartburn episodes. As for bloating, it was detected in patients with duodenal ulcer (11–26.2%), in gastric ulcer 11– (32.9%). The main pathogenetic aspects of heartburn episodes were found to be diffuse fundal glands hyperplasia and high acidity (duodenal ulcer and pyloric anterior ulcer). It was also found that a large percentage of patients were not treated properly, leading to impaired ability to work and changes in quality of life and disease progression.

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Features of Depressed State of Men with Sexual Disorders Based on Gastric Ulcer and Duodenal Ulcer

Family Medicine ◽

10.30841/2307-5112.5.2016.248843 ◽

2016 ◽

pp. 138-142

Author(s):

Yurii Gurzhenko ◽

Vasyl Soroka

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Research Evaluation ◽

Close Correlation ◽

Sexual Disorders ◽

Ulcer Disease ◽

Negative Effect ◽

Personal Anxiety

The aim of the research: evaluation of the peculiarities of anxiety in male patients with gastric ulcer and duodenal ulcer, which are sexual disorders. Materials and methods. The research is based on the generalization of the results of complex examination and treatment of 130 patients with peptic ulcer of duodenum and stomach in remission who have sexual disorders. The patients were divided into three groups: basic, comparative and referential. Was used C. Spielberger’s self-evaluation scale of situational and personal anxiety and M. Kurgan’s methodology. Results. It has been proven that the level of personal anxiety has a close correlation with the duration of peptic ulcer disease. Conclusion. The presence of peptic ulcer disease creates a certain basis for further psychological stress, similar to negative effect with the development of sexual disorders. Among the examined patients prevailed the somatized nature of depression.

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Psychological correlates of gastric and duodenal ulcer disease

Psychological Medicine ◽

10.1017/s0033291700009193 ◽

1986 ◽

Vol 16 (2) ◽

pp. 365-371 ◽

Cited By ~ 18

Author(s):

C. Tennant ◽

Kerry Goulston ◽

Pauline Langeluddecke

Keyword(s):

Duodenal Ulcer ◽

Gastric Ulcer ◽

Trait Anxiety ◽

Gastrointestinal Symptoms ◽

Physical Symptoms ◽

Duodenal Ulcer Disease ◽

Ulcer Disease ◽

Psychological Correlates ◽

Confounding Variables ◽

Symptom Measures

SynopsisPsychological correlates of gastric and duodenal ulcer disease were assessed in a group of somewhat older patients with ulcer disease identified by endoscopy. Associations between both ulcer types and symptom measures (anxiety and depression) seemed only to reflect severity or chronicity of gastrointestinal symptoms or the impending endoscopy procedure. Associations with ‘trait’ psychological indices may be of causal significance. Duodenal ulcer patients had higher ‘introversion’ and ‘psychoticism’ scores (on the EPQ) than controls, while gastric ulcer patients had higher psychoticism scores and ‘trait anxiety’ scores. These findings could not be attributed to confounding variables.When the two ulcer groups were compared, the gastric ulcer group had significantly higher neuroticism, psychoticism and hostility scores which were not attributable to confounding variables. The higher depression scores in gastric ulcer patients, however, simply reflected the greater chronicity of their physical symptoms. The groups did not differ significantly on measures of trait anxiety, tension, introversion or Type A behaviour.

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CLINICAL PROFILE AND RISK FACTORS FOR BENIGN PEPTIC ULCER DISEASE IN A TERTIARY CARE CENTRE IN THE SUBHIMALAYAN RANGES OF NORTH INDIA

10.36106/paripex/5002629 ◽

2020 ◽

pp. 1-3

Author(s):

Vishal Bodh ◽

Rajesh Sharma ◽

Brij Sharma

Keyword(s):

Risk Factors ◽

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Low Socioeconomic Status ◽

Low Socioeconomic ◽

Ulcer Disease ◽

H Pylori ◽

Upper Gastrointestinal

Background: To study the clinical profile and risk factors for benign peptic ulcer disease. Material and Methods: A total of 200 patients of peptic ulcer disease (PUD) diagnosed on upper gastrointestinal endoscopy were included. The socio-demographic profile, risk factors, clinical and endoscopic findings were recorded. Results: A total of 200 patients of peptic ulcer disease were included, out of which 168(84%) were males, while 32 (16%) were females. Most of the patients (61%) were between age 31-60 years with mean age of 47 years. Most of patients were farmers from rural areas and belonged to low socioeconomic status. History of smoking and alcohol intake was present in 106(53%) and 70( 35 %) patients respectively.Most common presenting complaints were epigastric pain and/or burning in 72 (36%) , followed by upper abdomen discomfort 70(35%) and upper gastrointestinal bleed 58(29%). Duodenal ulcer (DU) was present in 152 (76%), gastric ulcer(GU) in 30 (15%) while 18 (9%) had both DU and GU. Most of the patients had Forrest III ulcer 167 (83.5%) followed by Forrest IIc ulcer 13 (6.5%). H. pylori was detected by rapid urease test on endoscopic biopsy specimen in 156 (78 % ) of the total 200 patients of peptic ulcer disease. H. pylori was detected in 78.94 % case of DU, 60% case of GU and 100% cases of both DU and GU. Conclusion: PUD is a multifactorial health problem affecting almost all populations worldwide. . The major risk factors associated with PUD included tobacco and alcohol consumption besides low socioeconomic status, rural background and occupation of farming. Our findings indicate the substantial role of H. pylori and painkiller ingestion in the pathogenesis of PUD. Duodenal ulcer is most common type followed by gastric ulcer. Most had Forrest III ulcer followed by Forrest IIc.

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Rationale improve diagnosis of sexual disorders in patients with somatic profile for example gastric ulcer and duodenal

HEALTH OF WOMAN ◽

10.15574/hw.2016.116.60 ◽

2016 ◽

pp. 60-64

Author(s):

Y. Gurzhenko ◽

◽

V. Soroka ◽

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Depressive Mood ◽

Sexual Life ◽

Sexual Disorders ◽

Somatic Anxiety ◽

Ulcer Disease ◽

Low Level

The objective: The study and improvement of diagnosis of sexual disorders in patients of somatic profile, with ulcerative disease of the stomach (UDS) and peptic ulcer disease duodenal ulcer (DU). Patients and methods. For 3 years carried out a comprehensive examination and treatment of 130 patients with DU in remission and UDS in remission, which is observed sexual disorders; the first was 76 (58.5±4.3%) patients, second – 54 (41.5±4.3%); p<0.05. They represented the main group. The comparison group included 100 male patients with DU and UDS, which were also in remission, but did not complain of sexual disorders; accordingly, they were of 66.0±4.7% and 34.0±3.3%; p<0.05. Also was used a reference group (control) of 20 healthy men. All groups were matched for age (average age in the major groups – 34.0±1.7 years in the control to 32.0±4.0 years), and the first two – and duration of ulcer (average period in the history of 6.9±0.7 years). Results. The frequency of manifestations of depression in patients with DU and UDS with sexual disorders identified parameters, among which reliably allocated to mental anxiety (85.4±3.1%), depressive mood (73.1±3.8%), somatic anxiety (66.1±4.3%), reduced efficiency and activity (64.6±4.1 percent). Their combination in various embodiments burdened the situation. Exclusively in patients with peptic ulcer disease was most prevalent somatic anxiety (32.0±4.6%), depressive mood (28.0±4.5%), capacity and activity (24.0±4.2%). The majority of patients with DU and UDS with sexual disorders (60,8±4,2%) recorded a high level of personal anxiety and almost equally often low to moderate (19,2±3,4% and 20.0±3.4%, respectively). However, 93.0% of patients only with peptic ulcer were also noted its low level of expression. At the same time, among the first significantly more often observed the average level of situational anxiety (62.3±4.2%), every third - low (28.5±3.9%) and others (10.0 per cent), whereas among second - frequency dominated low level (63.0±4.9% vs 31.0±4.9% of the average and 6.0±2.3% - high). Conclusion. Justified the principle of improving the early identification of sexual disorders in men with chronic somatic diseases, for example peptic ulcer disease, the essence of which is to be included in the anamnestic and diagnostic method of two key issues, namely: the satisfaction of sexual intercourse and satisfaction with sexual life in General. Key words: gastric ulcer and duodenal ulcer, sexual dysfunction, diagnosis.

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Peptic Ulcer Diseases

10.2310/tywc.1114 ◽

2018 ◽

Author(s):

Edward A Lew

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Manifestations ◽

Muscularis Propria ◽

Gastric Ulcers ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 76 references.

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Study of Endoscopic Findings in First Episode of Upper Gastrointestinal Bleeding

Journal of Advances in Internal Medicine ◽

10.3126/jaim.v10i1.37085 ◽

2021 ◽

Vol 10 (1) ◽

pp. 14-19

Author(s):

Krishna Raj Adhikari ◽

Rajesh Kumar Mandal

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Gastrointestinal Bleeding ◽

Upper Gastrointestinal Bleeding ◽

First Episode ◽

Gastric Erosion ◽

Ulcer Disease ◽

Endoscopic Findings ◽

Upper Gastrointestinal

Background and Aims: Upper gastrointestinal bleeding (UGIB) is one of the most common and grave emergencies encountered in Emergency department in Tertiary health care centre in our country. Upper endoscopy has a crucial role in the diagnosis and treatment of upper gastrointestinal bleeding. The aim of this study is to assess the endoscopic findings in patients presenting with first episode of UGIB. Methods: This was a hospital based cross sectional study of patients with haematemesis, melena or both who underwent UGI endoscopy at Bir Hospital during January 2019 to January 2020. Patient demographics, site and nature of lesions and risk factors for bleeding were analyzed. Results: Among 72 enrolled patients 48 (66.67 %) were male and 24 (33.3 %) were female. Haematemesis 27% was the most common presenting complain followed by melena 25.5% and fainting/ dizziness 22.5%. Endoscopy was done in all cases and gastric ulcer disease 27.8% was the commonest cause of first episode of UGI bleeding followed by variceal bleeding, gastric erosion and duodenal ulcer, 25%, 16.7%, 12.5% respectively. Conclusions: Peptic ulcer disease was the most common cause of first episode of UGI bleeding in our context. Among peptic ulcer diseases gastric ulcer was more common than duodenal ulcer. Haematemesis and melena were the commonest clinical presentation of UGI bleeding.

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Peptic Ulcer Diseases

10.2310/im.1114 ◽

2020 ◽

Author(s):

Edward A Lew

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Manifestations ◽

Muscularis Propria ◽

Gastric Ulcers ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 5 figures, 6 tables and 78 references.

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PREVALENCE OF H. PYLORI

The Professional Medical Journal ◽

10.29309/tpmj/2010.17.03.2536 ◽

2010 ◽

Vol 17 (03) ◽

pp. 431-439

Author(s):

MASOOD JAVED ◽

KHALID AMIN ◽

DILSHAD MUHAMMAD ◽

Aamir Husain ◽

Nasir Mahmood

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Protective Mechanism ◽

Skilled Workers ◽

Ulcer Disease ◽

Peptic Disease ◽

Number Of Patients ◽

H Pylori

Background: Acid peptic disease is a world wide problem among all the age groups and both sexes. Duodenal ulcer is common as compared to gastric ulcer. Its prevalence being 4:1 in USA & UK and 5:1 in Pakistan1,2,3. Etiology of peptic ulcer is almost certainly multi-factorial. Basic paradigm for ulcer disease is the imbalance between the digestive activity of acid and pepsin and the protective mechanism in place toresist mucosal digestion. Over the past few years a new line of thought has been evolved after isolating spiral campylobacter like organism from antral biopsy specimens. H pylori is now considered to be an important if not the only causative agent of gastritis and peptic ulcer disease. The dictum; No acid – No ulcer summarized the pathogenesis of peptic ulcer disease but new dictum seems to be; No H.pylori -No ulcer4,5, as over90% of Duodenal ulcer and 70% of Gastric ulcer patients are infected byH.Pylori6. Aim of the study was to evaluate the prevalence of H.pylori among Duodenal ulcer patients at Faisalabad District and its suburbs. Study Design: Descriptive Study. Period: From Mar 2008 to Oct 2008. Materials and Methods: 50 patients (40 Males, 10 Females) belonging to Faisalabad District and surrounding areas with upper gastrointestinal symptoms of acid peptic disease and endoscopy proved duodenal ulcer were subjected to gastric antral mucosal biopsies for evaluation of the H.Pylori status with the help of unease test and histological examination of biopsy specimen. Results: Epigastric pain was the most frequent symptom 90%. (46 out of 50 patients). 92% showed evidence of H. pylori infection. Maximum incidence of H. pylori was recordedin age group IV (46—55 years). Maximum number of patients was skilled workers (35 out of 50) 70%. 80 % of the patients belonged to lower and middle class. Percentage of H.pylori positivity was 89.1 % and 84.34 %. Conclusions: Acceptance of contributory role and high prevalence rate of H.pylori instigates us for addition of antimicrobial treatment to the conventional treatment with H2 Blockers and PPIs which is cost effectiveand alter the course of the disease.

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