A SECOND USE FOR THE GROUP G2

1970 ◽  
Vol 31 (C4) ◽  
pp. C4-9-C4-16
Author(s):  
B. R. JUDD
Keyword(s):  
Author(s):  
Anton Hemerijck

The final chapter concludes with five contemporary ‘uses’ of social investment, in full recognition of limits underscored by critics. The first ‘use’ of social investment therefore concerns its ‘paradigmatic’ bearings. To what extent does social investment represent a distinct policy paradigm for twenty-first-century welfare capitalism? A second ‘use’ relates to paradigm change, in the sense of theoretical progress inspiring interdisciplinary methodological innovation, in particular with respect to the empirical assessment of well-being ‘returns’ on social investment. The third more practical ‘use’ covers the identification of virtuous social investment policy mixes of ‘stocks’, ‘flows’, and ‘buffers’. The fourth ‘use’ is geographically confined to the European conundrum of overcoming the fiscal austerity to make way for social investment reform, as means to reignite socioeconomic convergence, at least for the Eurozone. The more general final use of social investment bears on the ‘politics of social investment’ in the aftermath of the financial crisis.


2019 ◽  
Vol 216 (5) ◽  
pp. 250-253 ◽  
Author(s):  
Paul J. Harrison ◽  
Elizabeth M. Tunbridge ◽  
Annette C. Dolphin ◽  
Jeremy Hall

SummaryWe reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.


INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (05) ◽  
pp. 5-6
Author(s):  
Gopakumar G. Nair

Repurposing of drugs was most often a strategic approach, though by “serendipity” in few instances. Early practice of pharmacovigilance in USA, led to near ‘serendipitous’ addition to market value for many “first use” drugs. Glaxo-Welcome’s Bupropion brand “Wellbutrin” was first approved for treatment of depression. While “Wellbutrin” received an average response in the anti-depression segment, pharmacovigilance reports to FDA was perplexing. Patients gave conflicting response. While a few wanted to change to another drug, many others wanted to continue the use of the prescribed drug even after being advised to stop. The reason when investigated, was that the patients felt the urge to discontinue smoking, which was acceptable to some, while not to others. When this finding was received by the FDA from multiple specialists, Glaxo-Welcome was asked to conduct a full study on a priority basis. Consequently, FDA granted a fast track approval for use of Bupropion for smoking cessation. Antidepressant “Wellbutrin” opened up new pathway for smokers to “kick the Butts” through its second use “Avatar”, in form of “Zyban” for smoking cessation and become the first global breakthrough drug of choice for this second use. Pharmacovigilance helps in developing a road map for secondary use.


2021 ◽  
Author(s):  
Coralie Chevallier ◽  
Anne-Sophie Hacquin ◽  
Hugo Mercier

We offer three recommendations to increase COVID-19 vaccination rates. First, use communication campaigns leveraging evidence-based levers and argumentation tools with experts. Second, use behavioral insights to make vaccination more accessible. Third, help early adopters communicate about their decision to be vaccinated to accelerate the emergence of pro-vaccination norms.


2014 ◽  
Vol 4 (3) ◽  
pp. 1-13
Author(s):  
Khadoudja Ghanem

In this paper the authors propose a semantic approach to document categorization. The idea is to create for each category a semantic index (representative term vector) by performing a local Latent Semantic Analysis (LSA) followed by a clustering process. A second use of LSA (Global LSA) is adopted on a term-Class matrix in order to retrieve the class which is the most similar to the query (document to classify) in the same way where the LSA is used to retrieve documents which are the most similar to a query in Information Retrieval. The proposed system is evaluated on a popular dataset which is 20 Newsgroup corpus. Obtained results show the effectiveness of the method compared with those obtained with the classic KNN and SVM classifiers as well as with methods presented in the literature. Experimental results show that the new method has high precision and recall rates and classification accuracy is significantly improved.


2019 ◽  
Vol 28 (8) ◽  
pp. 534-541
Author(s):  
Claas Roes ◽  
Leanne Calladine ◽  
Clare Morris

Objective: To determine the clinical effect and consequential levels of health professionals and patient satisfaction with the results of debridement episodes of wounds with visible slough and/or scaly skin using monofilament fibre debridement technology. Methods: This was a non-comparative, open label evaluation conducted in static/non-healing acute and chronic wounds with visible slough and/or scaly skin that required debridement. Monofilament fibre debridement technology was applied in 1–2 sequential treatment episodes during normal clinical practice which followed local practice, guidelines or formularies. Following the clinical phase of the evaluation, health professionals were invited to complete an online survey of the clinical outcomes and their satisfaction with them. Results: Survey questions were answered by 1129 health professionals. Wounds managed using the monofilament fibre debridement technology during this evaluation included leg ulcers (63%), pressure ulcers (10%), dehisced surgical wounds (3%), diabetic foot ulcers (8%) and other wounds (13%). ‘Other’ wound types included acute dirty wounds, burns, cellulitis, psoriasis, diabetic amputation wounds, dry flaky skin, moisture wounds, trauma, varicose eczema. Of the wounds, 12% were reported as non-static. There was visible change in the wound and/or skin after first use of the monofilament fibre debridement technology in a high proportion of all wound types, and a further increase in the proportion of wounds with visible change after the second use. The visible difference was significant for both static and non-static wounds. User and patient satisfaction with all clinical outcomes were high, whether or not the user and patient had previous experience of monofilament fibre debridement technology. Conclusion: Monofilament fibre debridement technology provides rapid, visible and effective debridement of slough and scaly skin after one application and further visible improvement after two applications in static and non-static wounds. Health professionals and patients report high levels of satisfaction with outcomes following application of the monofilament fibre debridement technology.


2012 ◽  
Vol 602-604 ◽  
pp. 1171-1174
Author(s):  
Long Long Gao ◽  
Yan Zhen Yu ◽  
Miao Wan Li ◽  
Yu Xing Zhou ◽  
Hua Dong Zhang

In order to effectively resolve pollution issue of water quenched slag and its comprehensive use or second use of materials, the water quenched slag filter material is developed using water quenched slag with the addition of adhesion-increasing agent and porogen by commingle, pelletizing and curing. Experimental results indicate that water quenched slag filter material is used as filter medium in biological aerated filter for wastewater treatment,and the removal rate of COD, NH3-N comes up to 84.62%,90.20% respectively. The filter material is much more predominant and possesses a much wider application prospect in the treatment of wastewate.


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