scholarly journals Fabrication and bioresorbability of Ag- and Ta-containing amorphous calcium phosphate films formed on titanium substrates by RF magnetron sputtering

2020 ◽  
Vol 321 ◽  
pp. 05007
Author(s):  
Jun Wu ◽  
Kyosuke Ueda ◽  
Takayuki Narushima
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Amorphous Calcium Phosphate ◽  
Biomedical Applications ◽  
Rf Magnetron Sputtering ◽  
Coating Films ◽  
Depth Direction ◽  
Simulated Body Fluids ◽  
Titanium Substrates ◽  
Hcl Solution

Silver (Ag)- and tantalum (Ta)-containing amorphous calcium phosphate (ACP) coating films were fabricated on titanium substrates by radiofrequency magnetron sputtering for biomedical applications. The sputtering targets were hot-pressed into 10 mol% Ag-containing ß-tricalcium phosphate sintered compacts with and without 8 mol% Ta. The fabricated ACP coating films were dense and smooth, with all elements distributed homogeneously along the depth direction. In addition, Ag existed as ions in the ACP regardless of the presence of Ta. The resorbability of the Ag-containing ACP coating films in simulated body fluids was suppressed by the addition of Ta. The concentration of detected Ag ions was higher in diluted nutrient broth solution than in Tris-HCl solution.

Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

2009 ◽  
Vol 631-632 ◽  
pp. 211-216 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
T. Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

Calcium Phosphate Coating on Titanium Using Dry Process

2010 ◽  
Vol 654-656 ◽  
pp. 2162-2167
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Jun Kurihara ◽  
Hiroshi Kawamura
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films ◽  
Removal Torque

Oxyapatite, amorphous calcium phosphate, and double-layered calcium phosphate coating films were fabricated on mirror-polished commercially pure titanium (CP Ti) and blasted Ti-6Al-4V alloy substrates by radiofrequency (RF) magnetron sputtering; the properties of these films were evaluated in vivo and in vitro. The bonding strength between the calcium phosphate films and the Ti substrates was higher than 50 MPa. This value is higher than the bonding strength reported in the case of plasma-sprayed calcium phosphate coating films fabricated on Ti substrates. The removal torque of screw-type blasted Ti-6Al-4V alloy implants in the femurs of Japanese white rabbits increased with the duration of implantation, and the removal torque values of the coated implants was observed to be higher than those of the non-coated implants. In vitro and in vivo studies indicate that coating Ti implants with calcium phosphate films using RF magnetron sputtering is effective in improving the bone compatibility of Ti implants. Finally, the factors that should be considered in fabricating biomedical coating films were discussed.

Characterization of Calcium Phosphate Films Prepared by RF Magnetron Sputtering

2005 ◽  
Vol 888 ◽  
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Amorphous Calcium Phosphate ◽  
Pure Titanium ◽  
Active Surface ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Commercially Pure Titanium ◽  
Cp Ti

ABSTRACTCalcium phosphate films were prepared on commercially pure titanium (CP-Ti) substrates by RF magnetron sputtering using β-tricalcium phosphate targets. XRD and FTIR analyses showed that the films consisted of amorphous calcium phosphate and oxyapatite phases. The (002) preferred orientation of the oxyapatite phase was observed depending on the oxygen gas concentration in the sputtering gas. The surface reactions of the calcium phosphate films were investigated in Hanks' solution and PBS(-). Apatite crystallites were detected on the films after immersion for 7 days. An active surface reaction was observed on the amorphous calcium phosphate films during immersion in PBS(-). The CP-Ti plates coated with the calcium phosphate films were placed on the mandible of male Japanese white rabbits. These results suggest that the calcium phosphate coating improves the biocompatibility of titanium implants with bone.

Physical–chemical and biological behavior of an amorphous calcium phosphate thin film produced by RF-magnetron sputtering

2012 ◽  
Vol 32 (7) ◽  
pp. 2086-2095 ◽  
Author(s):  
Euler A. dos Santos ◽  
Simona Moldovan ◽  
Mihaela Mateescu ◽  
Jacques Faerber ◽  
Manuel Acosta ◽  
...  
Keyword(s):  
Thin Film ◽  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Amorphous Calcium Phosphate ◽  
Rf Magnetron Sputtering ◽  
Biological Behavior ◽  
Physical Chemical

In Vitro Evaluation of RF Magnetron-Sputtered Calcium Phosphate Films on Titanium

2007 ◽  
Vol 352 ◽  
pp. 305-309
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
Takashi Goto
Keyword(s):  
Calcium Phosphate ◽  
Calcium Ions ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Apatite Formation ◽  
Coating Films ◽  
Before And After ◽  
Phosphate Buffered Saline ◽  
Titanium Substrates

Calcium phosphate coating films were fabricated on mirror-polished or blast-treated titanium substrates using radio-frequency (RF) magnetron sputtering and they were evaluated in vitro. Immersion tests for the films were conducted using phosphate-buffered saline (PBS(-)), and apatite formation and the elution of calcium ions from the films were investigated. The bonding strengths between the calcium phosphate films and titanium substrates before and after the immersion tests were evaluated. After the immersion tests, a decrease in the bonding strength was observed for the coating films on the mirror-polished titanium substrates, while that for the blast-treated titanium substrates was almost the same as that before the immersion tests.

scholarly journals Evaluation of Calcium Phosphate Coating Films on Titanium Fabricated Using RF Magnetron Sputtering

2007 ◽  
Vol 48 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Fabrication of calcium phosphate films for coating on titanium substrates heated up to 773 K by RF magnetron sputtering and their evaluations

2007 ◽  
Vol 2 (3) ◽  
pp. S160-S166 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
Masayuki Taira ◽  
Tomoyuki Katsube
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Rf Magnetron Sputtering ◽  
Titanium Substrates

Calcium Phosphate Films Coated on Titanium by RF Magnetron Sputtering for Medical Applications

2007 ◽  
Vol 539-543 ◽  
pp. 551-556 ◽  
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Calcium Ion ◽  
Pure Titanium ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Apatite Formation ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Titanium Substrates

Calcium phosphate films were coated on commercially pure titanium substrates by radiofrequency magnetron sputtering using β-tricalcium phosphate targets. The films consisted of amorphous calcium phosphate and oxyapatite phases. Immersion tests of the films were carried out in Hanks’ solution and PBS(-), and apatite formation and calcium ion elution from the films were investigated. The titanium cylinders coated with calcium phosphate films were implanted into the mandibles of beagle dogs. These results suggest that coating with calcium phosphate improves the biocompatibility of titanium implants with bone tissue.

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