scholarly journals Remission of clinical signs of adult-onset generalized demodicosis after treatment for concurrent babesiosis and/or granulocytic ehrlichiosis in dogs

Parasite ◽  
2007 ◽  
Vol 14 (4) ◽  
pp. 339-341 ◽  
Author(s):  
W. Tarello
Keyword(s):  
Clinical Signs ◽  
Adult Onset ◽  
Granulocytic Ehrlichiosis

Three adult-onset autosomal recessive ataxias

2020 ◽  
pp. 10.1212/CPJ.0000000000000947
Author(s):  
Jordan A. Paulus ◽  
Melinda S. Burnett
Keyword(s):  
Cerebellar Ataxia ◽  
Autosomal Recessive ◽  
Late Onset ◽  
Clinical Signs ◽  
Allelic Frequency ◽  
Adult Onset ◽  
Recessive Mutations ◽  
Autosomal Recessive Cerebellar Ataxia ◽  
Tay Sachs Disease ◽  
Cerebellar Ataxias

Purpose of reviewThis review will increase vigilance for 3 autosomal recessive ataxias that look different clinically when presenting in adulthood rather than childhood.Recent findingsA study found a high allelic frequency for repeat expansions in the RFC1 gene, a cause of Cerebellar Ataxia, Neuropathy, Vestibular Areflexia syndrome, which presents exclusively in adults. This implies that autosomal recessive etiologies of adult-onset cerebellar ataxias may be more common than previously thought.SummaryAdult-onset cerebellar ataxias are commonly caused by mutations inherited in either an autosomal dominant or X-linked pattern, as most autosomal recessive mutations cause disease at earlier ages. However, some autosomal recessive etiologies such as Late-onset Tay Sachs disease, Very Late-Onset Friedreich's Ataxia, and ARSACS emerge in adulthood, with age at presentation influencing the progression and clinical signs of the disease. This review will cover the genetics, clinical presentation, and necessary diagnostic steps required to identify 3 causes of Autosomal Recessive Cerebellar Ataxia that manifest differently in adults vs children.

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with Chronic Fatigue Syndrome (cfs)

2003 ◽  
Vol 51 (1) ◽  
pp. 61-72 ◽  
Author(s):  
W. Tarello
Keyword(s):  
Inclusion Bodies ◽  
Central Italy ◽  
Clinical Signs ◽  
Chronic Fatigue ◽  
Granulocytic Ehrlichiosis ◽  
Protein Levels ◽  
Fatigue Syndrome ◽  
Imidocarb Dipropionate ◽  
Canine Population ◽  
Associated Symptoms

Medical records of thirty-five consecutive cases of canine granulocytic ehrlichiosis (CGE) diagnosed cytologically in Central Italy in 1995-2000 were analysed retrospectively. Tick exposure was reported in 16 dogs (45.7%) and concurrent babesiosis in 19 dogs (54.3%). Ehrlichia-like inclusion bodies were found in neutrophils in a percentage varying from 0.5% to 11%. Frequently recorded clinical signs included anorexia (71.4%), lethargy (45.7%), conjunctivitis (31.4%), fever (25.7%), lameness (20%) and ataxia (20%). Among the 16 representative dogs in which protein electrophoresis was performed, 10 (62.5%) showed high globulin levels and 6 (37.5%) had concurrent high total protein levels. During treatment with doxycycline, all associated symptoms, including those unusually described, such as pyoderma intertrigo, erythema, apparent blindness and oral papillomatosis, progressively disappeared in 31 (89%) out of 35 dogs. The efficacy of treatment was marked in dogs simultaneously treated twice with imidocarb dipropionate: among the 14 dogs in which a fast recovery was noted, 11 (80%) were concurrently affected by babesiosis and consequently treated with the specific medicament leading to excellent outcomes. The main conclusion is that CGE is present among dogs from Central Italy and should be included in the differential diagnosis of possible zoonotic agents affecting the canine population.

scholarly journals Human Granulocytic Ehrlichiosis Agent Infection in a Pony Vaccinated with a Borrelia burgdorferi Recombinant OspA Vaccine and Challenged by Exposure to Naturally Infected Ticks

2000 ◽  
Vol 7 (1) ◽  
pp. 68-71 ◽  
Author(s):  
Yung-Fu Chang ◽  
Sean P. McDonough ◽  
Chao-Fu Chang ◽  
Kwang-Soon Shin ◽  
William Yen ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Inclusion Bodies ◽  
Ixodes Scapularis ◽  
Clinical Signs ◽  
Buffy Coat ◽  
The Body ◽  
Granulocytic Ehrlichiosis ◽  
Flunixin Meglumine ◽  
Human Granulocytic Ehrlichiosis ◽  
Vector Dna

ABSTRACT A pony was vaccinated with recombinant OspA vaccine (rOspA) and then exposed 3 months later to Borrelia burgdorferi-infected ticks (Ixodes scapularis) collected in Westchester County, N.Y. At 2 weeks after tick exposure, the pony developed a high fever (105°F). Buffy coat smears showed that 20% of neutrophils contained ehrlichial inclusion bodies (morulae). Flunixin Meglumine (1 g daily) was given for 2 days, and the body temperature returned to normal. PCR for ehrlichial DNA was performed on blood samples for 10 consecutive days beginning when the pony was first febrile. This pony was monitored for another 3.5 months but developed no further clinical signs. The 44-kDa immunodominant human granulocytic ehrlichiosis antigen gene was amplified by PCR and cloned into a pCR2.1 vector. DNA sequence analysis of this gene showed it was only 8 bp different (99% identity) from the results reported by others (J.W. Ijdo et al., Infect. Immun. 66:3264–3269, 1998). Western blot analysis, growth inhibition assays, and repeated attempts to isolate B. burgdorferi all demonstrated the pony was protected against B. burgdorferi infection. These results highlight the potential for ticks to harbor and transmit several pathogens simultaneously, which further complicates the diagnosis and vaccination of these emerging tick-borne diseases.

Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus

2008 ◽  
Vol 68 (3) ◽  
pp. 412-415 ◽  
Author(s):  
I E A Hoffman ◽  
B R Lauwerys ◽  
F De Keyser ◽  
T W J Huizinga ◽  
D Isenberg ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Adult Onset ◽  
Systemic Lupus ◽  
Juvenile Onset ◽  
Ribosomal P ◽  
Onset Systemic Lupus Erythematosus

Objective:To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).Methods:Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae.Results:Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement.Conclusion:Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.

scholarly journals A Case Report of Canine Ehrlichia Infection in a Labrador Dog and its Therapeutic Management

2014 ◽  
Vol 12 (2) ◽  
pp. 237-239
Author(s):  
D Barman ◽  
BC Baishya ◽  
D Sarma ◽  
A Phukan ◽  
TC Dutta
Keyword(s):  
Clinical Signs ◽  
Supportive Therapy ◽  
Eastern Region ◽  
Important Species ◽  
Granulocytic Ehrlichiosis ◽  
Canine Monocytic Ehrlichiosis ◽  
The Family ◽  
Blood Smear Examination ◽  
North Eastern ◽  
Polymerase Chain

Ehrlichiosis is an important protozoan disease in canine caused by an intracellular gram – negative bacteria of the genus Ehrlichia, under the family Anaplasmataceae. The important species under the genus Ehrlichia are E. canis, E. ewingii and E. chaffeensis. Another two bacteria within the family Anaplasmataceae are Anaplasma platys (Syn: E. platys) and A. phagocytophilum ; on the other hand, E. platys and A. phagocytophilum are synonymous. Prevalence of ehrlichiosis remains high in north eastern region of India especially Assam but it remains undiagnosed due to lack of owner’s awareness. The incidences of ehrlichiosis in dog in Guwahati caused by E. canis and E. platys are recorded which are primarily responsible for canine monocytic ehrlichiosis and canine thrombocytic as well as granulocytic ehrlichiosis, respectively. A case of ehrlichiosis in canine was diagnosed based on clinical signs, blood smear examination and polymerase chain reaction (PCR). The dog was treated with two doses of diminazine diaceturate deep intramuscularly at 48 hours interval and doxycycline tablet orally for one month besides supportive therapy rendered during the period. After a month of treatment the dog showed recovery and by two months it recovered completely. Thus it can be inferred that, doxycycline along with other supportive medication for about a month could cure a critical case of canine ehrlichiosis.DOI: http://dx.doi.org/10.3329/bjvm.v12i2.21298 Bangl. J. Vet. Med. (2014). 12 (2): 237-239 

scholarly journals Experimental Transmission of Ehrlichia equi to Horses through Naturally Infected Ticks (Ixodes pacificus) from Northern California

1998 ◽  
Vol 36 (7) ◽  
pp. 2131-2134 ◽  
Author(s):  
Gerhard H. Reubel ◽  
Robert B. Kimsey ◽  
Jeffrey E. Barlough ◽  
John E. Madigan
Keyword(s):  
16S Rrna ◽  
16S Rrna Gene ◽  
Clinical Signs ◽  
16S Rrna Genes ◽  
Rrna Genes ◽  
Rrna Gene ◽  
Ixodes Pacificus ◽  
Experimental Transmission ◽  
Granulocytic Ehrlichiosis ◽  
Ehrlichia Equi

We report the experimental transmission of Ehrlichia equi from naturally infected Ixodes pacificus ticks to horses. Three weeks after exposure to ticks, two of three horses developed clinical signs compatible with E. equiinfection, while one horse remained asymptomatic. 16S rRNA gene PCR of blood leukocyte lysates was positive for all horses at various time points; two horses seroconverted. The 16S rRNA gene sequences amplified from tick-exposed horses showed more than 99% homology to corresponding fragments of the 16S rRNA genes of E. equi, Ehrlichia phagocytophila, and the human granulocytic ehrlichiosis agent.

scholarly journals Clinical signs and clinical pathology of horses with equine granulocytic ehrlichiosis

2007 ◽  
Vol 23 (4) ◽  
pp. 351-356
Author(s):  
G F Schusser ◽  
A Grosche ◽  
W O Kyaw ◽  
M Kölbl ◽  
S Recknagel ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Clinical Pathology ◽  
Granulocytic Ehrlichiosis

scholarly journals Identification of a Granulocytic Ehrlichia Strain Isolated from a Horse in Switzerland and Comparison with Other Rickettsiae of the Ehrlichia phagocytophilaGenogroup

1998 ◽  
Vol 36 (7) ◽  
pp. 2035-2037 ◽  
Author(s):  
Nicola Pusterla ◽  
Jon B. Huder ◽  
Karsten Feige ◽  
Hans Lutz
Keyword(s):  
Case Report ◽  
Nucleotide Sequence ◽  
16S Rrna ◽  
Clinical Signs ◽  
Buffy Coat ◽  
Rrna Gene ◽  
Granulocytic Ehrlichiosis ◽  
Ehrlichia Phagocytophila ◽  
Human Granulocytic Ehrlichiosis ◽  
Limb Edema

This case report describes a 12-year-old Arabian mare with granulocytic ehrlichiosis. Clinical signs included fever, apathy, anorexia, icterus, limb edema, and reluctance to move. Examination of buffy coat smears revealed Ehrlichia organisms in neutrophils and eosinophils. A band of 1,428 bp was amplified from DNA of leukocytes via nested PCR and was identified as part of theEhrlichia 16S rRNA gene. It differed from the gene sequences of Ehrlichia phagocytophila and E. equi at two and three positions, respectively. Interestingly, the nucleotide sequence of the 16S rRNA was 100% identical to that of the agent of human granulocytic ehrlichiosis.

scholarly journals Initial Cerebellar Ataxia in Hereditary Adult-Onset Primary Lateral Sclerosis

2021 ◽  
pp. 414-421
Author(s):  
José Gazulla ◽  
Silvia Izquierdo-Alvarez ◽  
Emilio Ruiz-Fernández ◽  
José Berciano
Keyword(s):  
Cerebellar Ataxia ◽  
Disease Onset ◽  
Clinical Signs ◽  
Muscle Stiffness ◽  
Disease Stage ◽  
Primary Lateral Sclerosis ◽  
Adult Onset ◽  
Insidious Onset ◽  
Primary Lateral ◽  
Lateral Sclerosis

Cerebellar ataxia preceding the apparition of primary lateral sclerosis (PLS) is reported herein. Three individuals from 2 independent kindreds experienced ataxia before developing clinical signs of PLS. Disease onset was during the sixth decade or later, and an insidious onset, with progression exceeding 11 years, was observed. Pathochrony was homogenous, consisting of initial gait instability, followed by hand dysmetria 2 years later. During a 5-year follow-up, cerebellar ataxia remained the sole clinical manifestation, preceding the appearance of muscle stiffness, which progressed to a paraparesis, and then to a purely spastic quadriparesis, over 4 years; pseudobulbar dysarthria and dysphagia appeared later. At this disease stage, limb spasticity, hyperactive jaw and limb stretch reflexes, extensor plantar responses, and a spastic dysarthria were found on examination; limb dysmetria and an ataxo-spastic gait were also found. No muscle atrophy or fasciculation was observed. Among ancillary tests, electromyographic studies performed 6 years after disease onset revealed normal motor unit action potentials and absence of spontaneous activity, in 2 individuals. MRI revealed normal cerebellum and brainstem in 2 cases. Inheritance was dominant in both kindreds, and extensive genetic testing was negative. It is concluded that cerebellar ataxia preceded the appearance of a purely spastic spinobulbar syndrome (which fulfilled the clinical diagnostic criteria for PLS) during a 5-year period in 3 patients with a hereditary, adult-onset form of PLS; subsequent disease progression was equivalent to that of sporadic PLS. Further studies are needed to fully delineate the clinical and genetic spectra of adult-onset PLS.

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