Impact of Vitamin D Status and Obesity on C-Reactive Protein in Kidney-Transplant Patients

Context: Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer. Objective: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients. Design: Prospective. Setting: Nephrology clinic. Patients: Thirty-eight renal transplant patients with serum 25-hydroxy-vitamin D (25-OH-vitamin D) levels below 20 ng/mL and transplanted at least 12 months. Intervention: One-time oral dose of 300 000 IU vitamin D3. Main Outcome Measures: Before and after vitamin D treatment, serum endocan, hs-CRP, calcium, phosphorus, and parathyroid hormone (PTH) levels were measured. Results: Median serum endocan and PTH values before vitamin D were significantly higher than those of after treatment values ( P = .001 and P < .001, respectively). On the other hand, serum total calcium and phosphorus levels before vitamin D treatment were lower than the values obtained after vitamin D treatment ( P = .0013 and P < .001, respectively). Serum hs-CRP was lower after vitamin D therapy than before, but the difference was not statistically significant ( P = .06). A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = −.36, P = .02). Conclusion: This study has revealed that vitamin D treatment reduced markers of endothelial dysfunction in patients with renal transplantation and vitamin D deficiency.

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Determination of vitamin D (25[OH]D) levels in kidney transplant patients and relevance thereof, in accordance with the glomerular filtration rate

Revista Colombiana de Reumatología (English Edition) ◽

10.1016/j.rcreue.2019.01.005 ◽

2018 ◽

Vol 25 (3) ◽

pp. 161-168

Author(s):

César Augusto Restrepo Valencia ◽

José Vicente Aguirre Arango ◽

Daniela Cáceres Escobar

Keyword(s):

Vitamin D ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Kidney Transplant ◽

Filtration Rate ◽

Transplant Patients ◽

Kidney Transplant Patients

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Preserved circannual rhythm of vitamin D in kidney transplant patients

Swiss Medical Weekly ◽

10.4414/smw.2012.13672 ◽

2012 ◽

Author(s):

F Burkhalter ◽

S Schaub ◽

M Dickenmann

Keyword(s):

Vitamin D ◽

Kidney Transplant ◽

Circannual Rhythm ◽

Transplant Patients ◽

Kidney Transplant Patients

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Association between 25-OH-vitamin D and C-reactive protein as a marker of inflammation and cardiovascular risk in clinical practice

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563219851539 ◽

2019 ◽

Vol 56 (4) ◽

pp. 502-507

Author(s):

Elena Hernández-Álvarez ◽

Clara Pérez-Barrios ◽

Inmaculada Blanco-Navarro ◽

Belén Pérez-Sacristán ◽

Encarnación Donoso-Navarro ◽

...

Keyword(s):

Vitamin D ◽

Cardiovascular Risk ◽

Acute Phase ◽

Acute Phase Response ◽

Phase Response ◽

Vitamin D Status ◽

Serum Concentrations ◽

C Reactive Protein ◽

Reactive Protein ◽

25 Hydroxy Vitamin D

Background C-reactive protein is an acute phase response marker and, in an epidemiological context, a predictor of cardiovascular risk. 25-Hydroxy-vitamin D is the best indicator for vitamin D status, but it can be altered by the presence of acute phase response. Our aim was to evaluate the association between serum concentrations of 25-hydroxy-vitamin D and C-reactive protein to assist the interpretation of vitamin D status in a clinical context. Methods We evaluated retrospectively 5076 patients ( n = 4087 women) assessed for 25-hydroxy-vitamin D and C-reactive protein simultaneously. Subjects were classified according to the origin as hospitalized patients ( n = 410) and outpatients ( n = 4666). Outpatients included patients from specialized ( n = 3943) and primary ( n = 723) care. Serum 25-hydroxy-vitamin D was determined by using liquid chromatography and serum C-reactive protein by using immunoturbidimetry. Results Concentrations of 25-hydroxy-vitamin D and C-reactive protein were significantly different between hospitalized subjects and outpatients but not for specialized and primary care settings. Serum concentrations of 25-hydroxy-vitamin D decreased as C-reactive protein increased. Hospitalized patients with C-reactive protein concentrations >30 mg/L showed a significant reduction of 25-hydroxy-vitamin D. In outpatients with C-reactive protein within the reference range (≤10 mg/L), C-reactive protein concentrations were not significantly different for serum 25-hydroxy-vitamin D concentrations >37.5 nmol/L. Conclusions Our data question the reliability and usefulness of assessing 25-hydroxy-vitamin D status as a biomarker of nutritional status in patients displaying acute phase response, especially at concentrations of C-reactive protein >30 mg/L. In addition, the present study shows that in subjects displaying C-reactive protein values within the reference range, serum concentrations of 25-hydroxy-vitamin D >37.5 nmol/L were not associated with lower concentrations of cardiovascular risk (as assessed by C-reactive protein concentrations).

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Comparison of two different vitamin D supplementation regimens with oral calcifediol in kidney transplant patients

Journal of Nephrology ◽

10.1007/s40620-015-0237-6 ◽

2015 ◽

Vol 29 (5) ◽

pp. 703-709 ◽

Cited By ~ 6

Author(s):

Xoana Barros ◽

Nestor Y. Rodríguez ◽

David Fuster ◽

Lida Rodas ◽

Nuria Esforzado ◽

...

Keyword(s):

Vitamin D ◽

Kidney Transplant ◽

Vitamin D Supplementation ◽

Transplant Patients ◽

Kidney Transplant Patients

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Vitamin D Deficiency is Associated With Higher Level of High Sensitivity C-reactive Protein (Hs-crp) in Patients Undergoing Elective Coronary Stenting

10.21203/rs.3.rs-73096/v1 ◽

2020 ◽

Author(s):

farzaneh foroughinia ◽

Shaghayegh Mottaghi ◽

Mohammad Reza Alimardani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Inflammatory Diseases ◽

Inflammatory Marker ◽

Venous Blood ◽

High Sensitivity ◽

Vitamin D Status ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Abstract Background: Vitamin D deficiency, a prevalent worldwide concern, has been reported to have a pivotal role in many cardiovascular and inflammatory diseases. Percutaneous coronary intervention (PCI) is a therapeutic approach that may have several short-term and long-term cardiovascular complications, supposing to be mediated with high sensitive C-reactive protein (hs-CRP), an inflammatory marker. This study aimed to investigate the association between vitamin D status and hs-CRP level, as a prognostic marker, in patients undergoing elective PCI. Methods: The study population comprised of 150 patients who underwent elective coronary angioplasty. In order to measure vitamin D and hs-CRP levels, venous blood samples were obtained at baseline and 24 hours after PCI. Results: Our results showed a significant inverse relationship between post-PCI hs-CRP and also pre-post hs-CRP difference levels and vitamin D status. Conclusion: Hs-CRP content is higher in vitamin D deficient patients. Therefore, these patients, especially severely-deficient ones (25(OH)D<10ng/ml), may benefit from supplementation with vitamin D prior to PCI.

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