Does Infection with Human Immunodeficiency Virus Affect the Antibody Responses to Plasmodium falciparum Antigenic Determinants in Asymptomatic Pregnant Women?

2003 ◽  
Vol 46 (3) ◽  
pp. 164-172 ◽  
Author(s):  
J.G. Ayisi ◽  
OraLee H. Branch ◽  
A. Rafi-Janajreh ◽  
A.M. van Eijk ◽  
F.O. ter Kuile ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Plasmodium Falciparum ◽  
Pregnant Women ◽  
Antibody Responses ◽  
Antigenic Determinants ◽  
Immunodeficiency Virus

scholarly journals Plasmodium falciparum Strains Harboring Dihydrofolate Reductase with the I164L Mutation Are Absent in Malawi and Zambia Even under Antifolate Drug Pressure

2008 ◽  
Vol 52 (11) ◽  
pp. 3883-3888 ◽  
Author(s):  
Edwin Ochong ◽  
David J. Bell ◽  
David J. Johnson ◽  
Umberto D'Alessandro ◽  
Modest Mulenga ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Plasmodium Falciparum ◽  
Pregnant Women ◽  
Real Time ◽  
Dihydrofolate Reductase ◽  
Real Time Pcr ◽  
Mutant Allele ◽  
Drug Pressure ◽  
Immunodeficiency Virus ◽  
Pcr Method

ABSTRACT The Plasmodium falciparum dihydrofolate reductase (PfDHFR) enzyme is the target of pyrimethamine, a component of the antimalarial pyrimethamine-sulfadoxine. Resistance to this drug is associated primarily with mutations in the Pfdhfr gene. The I164L mutant allele is of particular interest, because strains possessing this mutation are highly resistant to pyrimethamine and to chlorproguanil, a component of chlorproguanil-dapsone. A recent study from Malawi reported this mutation at a prevalence of 4.7% in parasites from human immunodeficiency virus-positive pregnant women by using a real-time PCR method. These observations have huge implications for the use of pyrimethamine-sulfadoxine, chlorproguanil-dapsone, and future antifolate-artemisinin combinations in Africa. It was imperative that this finding be rigorously tested. We identified a number of critical limitations in the original genotyping strategy. Using a refined and validated real-time PCR strategy, we report here that this mutation was absent in 158 isolates from Malawi and 42 isolates from Zambia collected between 2003 and 2005.

scholarly journals Elevated Levels of Estradiol in Human Immunodeficiency Virus–Infected Pregnant Women on Protease Inhibitor–Based Regimens

2017 ◽  
Vol 66 (3) ◽  
pp. 420-427 ◽  
Author(s):  
Kayode A Balogun ◽  
Monica S Guzman Lenis ◽  
Eszter Papp ◽  
Mona Loutfy ◽  
Mark H Yudin ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Protease Inhibitor ◽  
Pregnant Women ◽  
Immunodeficiency Virus

scholarly journals Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil

2018 ◽  
Vol 51 (1) ◽  
pp. 21-29
Author(s):  
Aletheia Soares Sampaio ◽  
Ana Lucia Ribeiro de Vasconcelos ◽  
Clarice Neuenschwander Lins de Morais ◽  
George Tadeu Nunes Diniz ◽  
Anna Lígia de Castro Figueiredo ◽  
...  
Keyword(s):  
Immune Response ◽  
Human Immunodeficiency Virus ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Social Conditions ◽  
Sectional Study ◽  
Cross Sectional ◽  
Immunodeficiency Virus

scholarly journals Prevalence of human immunodeficiency virus infection among primigravida, in Karnataka

2018 ◽  
Vol 5 (12) ◽  
pp. 5448
Author(s):  
Vani Srinivas ◽  
T. L. N. Prasad ◽  
Rajesh T. Patil ◽  
Sunil D. Khaparde
Keyword(s):  
Human Immunodeficiency Virus ◽  
General Population ◽  
Pregnant Women ◽  
Data Extraction ◽  
Demographic Data ◽  
Striking Difference ◽  
Hiv Status ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
The Difference

Background: Karnataka is one of the six high human immunodeficiency virus (HIV) prevalent states in India. We estimated prevalence among primigravida attending antenatal clinics in Karnataka, assuming this as a proxy for HIV incidence level in the general population.Methods: We tried estimating prevalence among primigravida using cross sectional samples. Data was collected in structured data extraction sheet for the month of September 2011, from all Integrated and Counselling tested Centres (ICTCs) of Karnataka. All the pregnant women were tested as per national protocol. We analysed the basic demographic data, geographical distribution including HIV status of spouse of primigravida.Results: In September 2011, 87580, pregnant women were tested and 238 (0.26%) were found HIV positive of which, 95 (40%) were primigravida. Prevalence among primigravida, was 0.3%. The prevalence among primigravida was highest in Bagalkot (1.6%) district. In Yadgir, Kodagu and Udupi the prevalence was zero. The high prevalent blocks were Jamakhandi, Mudhol, Gokak, Hospet and Muddebihal. 73.7% spouse of positive primigravida were tested for HIV and among those tested, 87.1% were found HIV positive.Conclusions: There is striking difference in the prevalence of HIV among primigravida in different districts of Karnataka probably indicates the difference in effectiveness of preventive interventions in these districts and within blocks. The preventive programs should be reached out to the labourer's and farmers in the general population to prevent the new infections in the general population.

scholarly journals Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection

2007 ◽  
Vol 81 (12) ◽  
pp. 6187-6196 ◽  
Author(s):  
E. S. Gray ◽  
P. L. Moore ◽  
I. A. Choge ◽  
J. M. Decker ◽  
F. Bibollet-Ruche ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Subtype C ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT The study of the evolution and specificities of neutralizing antibodies during the course of human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of possible targets for vaccine design. In this study, we assessed the autologous and heterologous neutralization responses of 14 HIV-1 subtype C-infected individuals, using envelope clones obtained within the first 2 months postinfection. Our data show that potent but relatively strain-specific neutralizing antibodies develop within 3 to 12 months of HIV-1 infection. The magnitude of this response was associated with shorter V1-to-V5 envelope lengths and fewer glycosylation sites, particularly in the V1-V2 region. Anti-MPER antibodies were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing antibodies. However, neither anti-MPER nor anti-CD4i antibody specificity conferred neutralization breadth. These data provide insights into the kinetics, potency, breadth, and epitope specificity of neutralizing antibody responses in acute HIV-1 subtype C infection.

Human immunodeficiency virus/acquired immunodeficiency syndrome in pregnant women

1992 ◽  
Vol 2 (6) ◽  
pp. 773-802 ◽  
Author(s):  
Sten H. Vermund ◽  
Miriam A. Galbraith ◽  
Susan C. Ebner ◽  
Amy R. Sheon ◽  
Richard A. Kaslow
Keyword(s):  
Human Immunodeficiency Virus ◽  
Pregnant Women ◽  
Acquired Immunodeficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome
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