Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: The Rancho Bernardo Study

ObjectivesTo assess the prevalence of frailty and identify predictors of frailty among Chinese community-dwelling older adults with type 2 diabetes.DesignA cross-sectional design.SettingTwo community health centres in central China.Participants291 community-dwelling older adults aged ≥65 years with type 2 diabetes.Main outcome measuresData were collected via face-to-face interviews, anthropometric measurements, laboratory tests and community health files. The main outcome measure was frailty, as assessed by the frailty phenotype criteria. The multivariate logistic regression model was used to identify the predictors of frailty.ResultsThe prevalence of prefrailty and frailty were 51.5% and 19.2%, respectively. The significant predictors of frailty included alcohol drinking (ex-drinker) (OR 4.461, 95% CI 1.079 to 18.438), glycated haemoglobin (OR 1.434, 95% CI 1.045 to 1.968), nutritional status (malnutrition risk/malnutrition) (OR 8.062, 95% CI 2.470 to 26.317), depressive symptoms (OR 1.438, 95% CI 1.166 to 1.773) and exercise behaviour (OR 0.796, 95% CI 0.716 to 0.884).ConclusionsA high prevalence of frailty was found among older adults with type 2 diabetes in the Chinese community. Frailty identification and multifaceted interventions should be developed for this population, taking into consideration proper glycaemic control, nutritional instruction, depressive symptoms improvement and enhancement of self-care behaviours.

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Diagnostic differences and agreement between the original and revised European Working Group (EWGSOP) consensus definition for sarcopenia in community-dwelling older adults with type 2 diabetes mellitus

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2020.104081 ◽

2020 ◽

Vol 89 ◽

pp. 104081 ◽

Cited By ~ 1

Author(s):

Anthony Villani ◽

Rebecca McClure ◽

Michelle Barrett ◽

David Scott

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Older Adults ◽

Type 2 Diabetes Mellitus ◽

Working Group ◽

Community Dwelling ◽

Consensus Definition ◽

European Working ◽

Community Dwelling Older Adults

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The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults

BMC Geriatrics ◽

10.1186/s12877-020-01776-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Omar Yaxmehen Bello-Chavolla ◽

Carlos Alberto Aguilar-Salinas ◽

José Alberto Avila-Funes

Keyword(s):

Quality Of Life ◽

Type 2 Diabetes ◽

Older Adults ◽

Community Dwelling ◽

Related Factors ◽

Dementia Risk ◽

Sf 36 ◽

Community Dwelling Older Adults

Abstract Background The type 2 diabetes (T2D) specific dementia-risk score (DSDRS) was developed to evaluate dementia risk in older adults with T2D. T2D-related factors have been shown increase the risk of age-related conditions, which might also increase dementia risk. Here, we investigate the associations of DSDRS with frailty, disability, quality of life (QoL) and cognition in community-dwelling older adults with T2D. Methods We included 257 community-dwelling older adults with T2D to evaluate the association between DSDRS and Mini-mental state examination (MMSE), Isaac’s set-test (IST), clock drawing test (CDT), quality of life (SF-36), risk of malnutrition (Mini-Nutritional Assessment or MNA), as well as frailty, Katz’ and Lawton-Brody scores. We also assessed the phenotype and correlates of high-estimated dementia risk by assessing individuals with DSDRS >75th age-specific percentiles. Results Mean age of participants was 78.0 ± 6.2 years. DSDRS showed a significant correlation with MMSE test, IST, CDT, SF-36, MNA, Lawton-Brody and Katz scores, and an increasing number of frailty components. DSDRS was higher among frail, pre-frail, and subjects with limited ADL and IADL (p < 0.001). Participants with DSDRS >75th age-specific percentiles had lower education, MMSE, IST, SF-36, MNA, Katz, Lawton-Brody, and higher frailty scores. High-estimated 10-year dementia risk was associated with ADL and IADL disability, frailty and risk of malnutrition. When assessing individual components of DSDRS, T2D-related microvascular complications were associated to all outcome measures. Conclusion The DSDRS is associated with frailty, disability, malnutrition and lower cognitive performance. These findings support that T2D-related factors have significant burden on functional status, QoL, disability and dementia risk.

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Vitamin D Receptor Gene Polymorphisms, Metabolic Syndrome, and Type 2 Diabetes in Iranian Subjects: No Association with Observed SNPs

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000270 ◽

2016 ◽

Vol 86 (1-2) ◽

pp. 71-80 ◽

Cited By ~ 1

Author(s):

Sakineh Shab-Bidar ◽

Tirang R. Neyestani ◽

Abolghassem Djazayery

Keyword(s):

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Single Nucleotide ◽

Receptor Gene Polymorphisms

Abstract.Objective: This study aimed to investigate the associations between metabolic syndrome and type 2 diabetes and the presence of single nucleotide polymorphism of the vitamin D receptor gene in Iranian subjects with type 2 diabetes. Subjects and methods: Overall, 730 Iranian subjects (372 patients and 358 controls) were enrolled in this case-control study. Single nucleotide polymorphisms of the vitamin D receptor gene (FokI, BsmI, ApaI, and TaqI) were genotyped using the restriction fragment length polymorphism method. The statistical difference in genotype distribution among the groups was assessed by χ2 test. Logistic regression was performed to calculate odds ratios for the association of the genotype frequencies in different groups with the risk of metabolic syndrome and type 2 diabetes. Results: The most common genotypes for BsmI, ApaI, TaqI, and FokI were Bb, Aa, TT, and FF, respectively. Adjusted χ2 test revealed that there was no difference between the groups in the genotypes frequencies of 4 vitamin D receptor polymorphisms in type 2 diabetes subjects. On the other hand, type 2 diabetes subjects with Tt genotype presented a signifi cantly higher fasting blood glucose than those with TT and tt genotypes in TaqI polymorphisms (p = 0.009). Logistic regression showed no association between metabolic syndrome risk and vitamin D receptor genotypes. Conclusion: We found no evidence for the association between vitamin D receptor gene polymorphisms and the risk for type 2 diabetes and metabolic syndrome in Iranian subjects. Further examinations using genome-wide association in large prospective cohort studies are warranted.

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