Akute Nierenschädigung – Update 2018

2018 ◽  
Vol 143 (15) ◽  
pp. 1094-1096
Author(s):  
Daniel Patschan ◽  
Gerhard Müller
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Akute Nierenschädigung

Was ist neu? Prophylaxe der KM-induzierten akuten Nierenschädigung (AKI) (Kontrastmittelnephropathie, KMNP) Eine im November 2017 hochrangig publizierte Studie zeigt, dass die Anwendung von Natriumbikarbonat der Gabe von Natriumchlorid zur Prävention der Kontrastmittelnephropathie nicht überlegen ist. SGLT-2-Antagonisten und AKI SGLT-2-Antagonisten entfalten mutmaßlich protektive Effekte hinsichtlich einer CKD (chronic kidney disease). Neuere Beobachtungen lassen vermuten, dass bei behandelten Patienten ein höheres Risiko für die akute Nierenschädigung besteht. Zellbasierte Therapien der AKI Zellbasierte Therapieansätze der AKI sind in den letzten Jahren v. a. unter experimentellen Bedingungen evaluiert worden. Erste humane Studien mit mesenchymalen Stammzellen werden derzeit durchgeführt. Die Umsetzung zellbasierter Therapien bei humaner AKI ist allerdings noch mit zahlreichen Schwierigkeiten verbunden.

No effect of vitamin D supplementation on metabolic parameters but on lipids in patients with type 2 diabetes and chronic kidney disease

2020 ◽  
pp. 1-10
Author(s):  
Jiwoon Kim ◽  
Ji Sun Nam ◽  
Heejung Kim ◽  
Hye Sun Lee ◽  
Jung Eun Lee
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Supplementation ◽  
Lipid Profiles ◽  
Metabolic Parameters ◽  
Injection Group ◽  
Different Doses

Abstract. Background/Aims: Trials on the effects of cholecalciferol supplementation in type 2 diabetes with chronic kidney disease patients were underexplored. Therefore, the aim of this study was to investigate the effects of two different doses of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentrations and metabolic parameters in vitamin D-deficient Korean diabetes patients with chronic kidney disease. Methods: 92 patients completed this study: the placebo group (A, n = 33), the oral cholecalciferol 1,000 IU/day group (B, n = 34), or the single 200,000 IU injection group (C, n = 25, equivalent to 2,000 IU/day). 52% of the patients had less than 60 mL/min/1.73m2 of glomerular filtration rates. Laboratory test and pulse wave velocity were performed before and after supplementation. Results: After 12 weeks, serum 25(OH)D concentrations of the patients who received vitamin D supplementation were significantly increased (A, -2.4 ± 1.2 ng/mL vs. B, 10.7 ± 1.2 ng/mL vs. C, 14.6 ± 1.7 ng/mL; p < 0.001). In addition, the lipid profiles in the vitamin D injection group (C) showed a significant decrease in triglyceride and a rise in HDL cholesterol. However, the other parameters showed no differences. Conclusions: Our data indicated that two different doses and routes of vitamin D administration significantly and safely increased serum 25(OH)D concentrations in vitamin D-deficient diabetes patients with comorbid chronic kidney disease. In the group that received the higher vitamin D dose, the lipid profiles showed significant improvement, but there were no beneficial effects on other metabolic parameters.

Ankle-brachial index in chronic kidney disease

VASA ◽  
2012 ◽  
Vol 41 (3) ◽  
pp. 159-160
Author(s):  
Espinola-Klein ◽  
F. Dopheide ◽  
Gori
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Ankle Brachial Index
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