Einsatz und Nutzen funktioneller Parameter als Endpunkte in klinischen Ernährungsstudien

2018 ◽  
Vol 43 (03) ◽  
pp. 162-172
Author(s):  
Ulrike Haß ◽  
Susann Schwejda-Güttes ◽  
Katharina Kuhn ◽  
Anja Markant

Zusammenfassung Hintergrund Eine ausreichende Muskelkraft und -funktion stellt eine Grundvoraussetzung für die Teilhabe am alltäglichen Leben und der damit verbundenen Autonomie des Patienten dar. Der diagnostische und prognostische Einsatz funktioneller Parameter zur Einschätzung von Muskelkraft und -funktion gewinnt zunehmend an Bedeutung. Hinsichtlich des Nutzens dieser Parameter als Endpunkte in klinischen Ernährungsstudien besteht allerdings noch Klärungsbedarf. Material und Methoden Es wurde eine umfangreiche Literaturrecherche zur Extraktion und Evaluierung etablierter funktioneller Parameter in der medizinischen Literaturdatenbank Pubmed ausgeführt. Die folgenden, häufig in Ernährungsstudien angewendeten, 8 Parameter wurden detailliert aufgearbeitet und miteinander verglichen: Handgreifkraft, knee extension peak torque, Six-Minute-Walk Test (6MWT), Timed-Up-and-Go (TUG), Short Physical Performance Battery (SPPB), Physical Performance Test (PPT), Akzelerometrie und Barthel-Index. Ergebnisse und Schlussfolgerung Die Anwendung der funktionellen Parameter hat sich insbesondere in geriatrischen Ernährungsstudien bewährt. Hier zeigten sich neben der Handgreifkraft, dem SPPB und TUG auch das knee extension peak torque, der 6MWT sowie der Barthel-Index als geeignete funktionelle Endpunkte. Lediglich der PPT zeigte keine nennenswerten Vorteile gegenüber den in dieser Arbeit evaluierten funktionellen Parametern. Außerhalb der geriatrischen Population könnte die Akzelerometrie in der Onkologie als funktioneller Endpunkt in klinischen Ernährungsstudien herangezogen werden. Innerhalb der Intensivmedizin stellt die Nutzung funktioneller Parameter hinsichtlich der erforderlichen willkürlichen Muskelkraft derzeit noch eine Herausforderung dar.

Author(s):  
Rene Przkora ◽  
Kimberly Sibille ◽  
Sandra Victor ◽  
Matthew Meroney ◽  
Christiaan Leeuwenburgh ◽  
...  

Measurements of physical function after total knee arthroplasty (TKA) are uncertain and require investments for special equipment, space, and staff. Therefore, we evaluated the Short Physical Performance Battery (SPPB) 4 to 6 weeks preoperatively and 2 weeks following TKA as this test battery addresses lower extremity strength, coordination, and balance, without additional special investments. For context, we also employed the Six-Minute Walk test (6MWT) and peak torque knee extension. Our analysis consisted of three women and one man, with average ages of 68.3±3.9 years. Patients showed a decrease in all functional measurements: SPPB (mean change: −4.8±1.9, 44% decrease), 6MWT (−0.37±.21 m/s, 34% decrease), and peak torque (−11.8±8.8°/s, 68% decrease). Our findings suggest the SPPB is feasible and can be integrated easily in daily clinical practice.


Author(s):  
Julie Broderick ◽  
Sinead Kiernan ◽  
Niamh Murphy ◽  
Joanne Dowds ◽  
Cliona Ní Cheallaigh

Background: People who are homeless experience poor health. Reflective of overall health and factors such as acquired injuries, physical ability or functioning is often low among people who are homeless, but there is a lack of consistency of measures used to evaluate this construct. The aim of this study was to evaluate the feasibility of a broad test battery to evaluate limitations in physical functioning among people who are homeless. Methods: This cross-sectional, observational study occurred in a hospital in Dublin, Ireland. We evaluated lower extremity physical function (Short Physical Performance Battery), falls risk (timed up and go), functional capacity (six-minute walk test), stair-climbing ability (stair climb test), frailty (Clinical Frailty Scale), grip strength (handgrip dynamometer) and muscular mass (calf circumference measurement) in a population of people experiencing homelessness admitted for acute medical care. The test completion rate was evaluated for feasibility. Results: The completion rate varied: 65% (Short Physical Performance Battery), 55.4% (timed up and go), 38% (six-minute walk test), 31% (stair climb test), 97% (Clinical Frailty Scale), 75% (handgrip dynamometer), 74% (calf circumference measurement)). Collectively, the most common reasons for test non-participation were pain (24.1%, n = 40), not feeling well or able enough (20.1%, n = 33), and declined (11%, n = 18). Conclusion: The feasibility of the test battery was mixed as test participation rates varied from 31% to 97%. Physical functioning tests need to be carefully chosen for people who are homeless as many standard tests are unsuitable due to pain and poor physical ability.


Arthritis ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Robin L. Marcus ◽  
Yuri Yoshida ◽  
Whitney Meier ◽  
Christopher Peters ◽  
Paul C. LaStayo

Rehabilitation services are less-studied aspects of the management following total knee arthroplasty (TKA) despite long-term suboptimal physical functioning and chronic deficits in muscle function. This paper describes the preliminary findings of a six-week (12 session) eccentrically-biased rehabilitation program targeted at deficits in physical function and muscle function, initiated one month following surgery. A quasiexperimental, one group, pretest-posttest study with thirteen individuals (6 female, 7 male; mean age years) examined the effectiveness of an eccentrically-biased rehabilitation program. The program resulted in improvements in the primary physical function endpoints (SF-36 physical component summary and the six-minute walk test) with increases of 59% and 47%, respectively. Muscle function endpoints (knee extension strength and power) also increased 107% and 93%, respectively. Eccentrically-biased exercise used as an addition to rehabilitation may help amplify and accelerate physical function following TKA surgery.


2018 ◽  
Vol 66 (1) ◽  
pp. 31-36
Author(s):  
Marie Carmen Valenza ◽  
María José Ariza-Mateos ◽  
Araceli Ortiz-Rubio ◽  
Jesús Casilda-López ◽  
Ramón Romero-Fernández ◽  
...  

Introducción. El envejecimiento se ha relacionado con una mayor prevalencia de deterioro cognitivo. Las personas mayores con pérdida de funciones cognitivas presentan elevadas tasas de caídas. El desarrollo de las actividades de la vida diaria engloba dos o más tareas, siendo necesarios componentes cognitivos y motores.Objetivo. Analizar el rendimiento en pruebas sencillas y duales de sujetos en entorno residencial con diferentes grados de deterioro cognitivo.Materiales y métodos. Se realizó un estudio observacional de corte transversal en ancianos institucionalizados >65 años (n=80). Se evaluó el deterioro cognitivo con el Mini-Mental State Examination y se solicitó a los participantes realizar una tarea simple y dual en las pruebas Six-Minute Walk Test (6MWT) y Timed Up and Go (TUG).Resultados. Se distribuyeron los participantes en tres grupos. Se encontraron diferencias significativas entre los grupos con deterioro cognitivo y el grupo sin deterioro cognitivo para las pruebas 6MWT (p<0.05) y TUG (p<0.05), tanto en la tarea simple como en la tarea dual. Un peor rendimiento se asoció con una menor capacidad cognitiva.Conclusión. La severidad del deterioro cognitivo se encuentra relacionada con el desempeño en las tareas duales.


1970 ◽  
Vol 3 (2) ◽  
pp. 45-49
Author(s):  
Farzana Tabassum ◽  
Meerjady Sabrina Flora

There is growing recognition that the complications associated with type-2 diabetes may translate into functional impairments in older people. This cross sectional study was conducted between January and June 2008 to determine the influence of diabetes on physical functions in an elderly (≥55 years) population. Fifty-five elderly diabetics attending the out-patient department of a diabetic centre were selected by convenient sampling and compared with fifty-five non-diabetic elderly persons of the near-by community. Their physical functions were assessed by Barthel Index, SF-36 Health Survey and Modified Physical Performance test. Diabetic elderly persons, on average, obtained lower scores in all these three tests. After removing the effect of socio-demographic variables, influence of diabetes on level of independence measured by Barthel Index did not persist. However, the difference in SF-36 health survey and Modified Physical Performance test scores between diabetics and non-diabetics remained significant after controlling for socio-demographic variables. The current study showed influence of diabetes on physical functions in the elderly. People should be motivated and guided properly to practice a healthy lifestyle in order to prevent and control diabetes and thus avoid complications of diabetes mellitus and disabilities in later life. Ibrahim Med. Coll. J. 2009; 3(2): 45-49 Keywords: Diabetes mellitus, Physical function, Barthel Index, Short Form-36 Health Survey, Modified Physical Performance Test. DOI: 10.3329/imcj.v3i2.4162


2018 ◽  
Vol 66 (1) ◽  
pp. 31-36
Author(s):  
Marie Carmen Valenza ◽  
María José Ariza-Mateos ◽  
Araceli Ortiz-Rubio ◽  
Jesús Casilda-López ◽  
Ramón Romero-Fernández ◽  
...  

Introducción. El envejecimiento se ha relacionado con una mayor prevalencia de deterioro cognitivo. Las personas mayores con pérdida de funciones cognitivas presentan elevadas tasas de caídas. El desarrollo de las actividades de la vida diaria engloba dos o más tareas, siendo necesarios componentes cognitivos y motores.Objetivo. Analizar el rendimiento en pruebas sencillas y duales de sujetos en entorno residencial con diferentes grados de deterioro cognitivo.Materiales y métodos. Se realizó un estudio observacional de corte transversal en ancianos institucionalizados >65 años (n=80). Se evaluó el deterioro cognitivo con el Mini-Mental State Examination y se solicitó a los participantes realizar una tarea simple y dual en las pruebas Six-Minute Walk Test (6MWT) y Timed Up and Go (TUG).Resultados. Se distribuyeron los participantes en tres grupos. Se encontraron diferencias significativas entre los grupos con deterioro cognitivo y el grupo sin deterioro cognitivo para las pruebas 6MWT (p<0.05) y TUG (p<0.05), tanto en la tarea simple como en la tarea dual. Un peor rendimiento se asoció con una menor capacidad cognitiva.Conclusión. La severidad del deterioro cognitivo se encuentra relacionada con el desempeño en las tareas duales.


2016 ◽  
Vol 47 (S 01) ◽  
Author(s):  
S.-M. Park ◽  
C. McDonald ◽  
H. Sweeney ◽  
X. Luo ◽  
G. Elfring ◽  
...  

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