scholarly journals An international survey on recognition and characterization of atrophic gastritis and intestinal metaplasia

2020 ◽  
Vol 08 (10) ◽  
pp. E1365-E1370
Author(s):  
Hon Chi Yip ◽  
Noriya Uedo ◽  
Shannon M. Chan ◽  
Anthony Yuen Bun Teoh ◽  
Simon Kin Hung Wong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diagnostic Accuracy ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Classification Systems ◽  
International Survey ◽  
Screening And Surveillance ◽  
The World ◽  
The Difference

Abstract Background and study aims Atrophic gastritis (AG) and intestinal metaplasia (IM) are premalignant conditions of gastric cancer and endoscopic recognition and characterization may help in stratifying the gastric cancer risk for screening and surveillance. However, there is currently lack of consensus in defining the severity of AG and IM. We aimed to conduct an international survey to understand the current practice of endoscopists worldwide. Methods An online survey was designed to collect data regarding participants’ practice in endoscopic assessment of AG & IM. A test using images was conducted to evaluate the difference in accuracy of characterization of AG & IM. Results From July to October 2017, 249 endoscopists responded to the survey. Around 70 % of participants received some form of training on recognition of AG & IM. There was significant variety in the training received across different continents. One hundred seventy-six participants (70 %) would document the presence of both AG and IM, but the classification systems used were inconsistent between endoscopists. Overall accuracy in diagnosis of AG & IM in the image test was 84.5 % and 80.7 % respectively. The diagnostic accuracy was significantly higher among Japanese and Korean endoscopists compared to the rest of the world. Conclusion Training regarding endoscopic recognition of AG & IM differs significantly in different parts of the world. The difference in diagnostic accuracy for these premalignant gastric conditions may also explain the discrepancy in the early cancer detection rates among different countries. A simple unified classification system may be beneficial for better stratification of cancer risks.

scholarly journals Tu1030 AN INTERNATIONAL SURVEY ON RECOGNITION AND CHARACTERIZATION OF ATROPHIC GASTRITIS AND INTESTINAL METAPLASIA

2018 ◽  
Vol 87 (6) ◽  
pp. AB501-AB502
Author(s):  
Hon Chi Yip ◽  
Noriya Uedo ◽  
Shannon M. Chan ◽  
Vivien W. Wong ◽  
Anthony Y. Teoh ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
International Survey

Discovery and genetic characterization of intestinal metaplasia in the Helicobacter felis-infected mouse model of gastric cancer

2018 ◽  
Vol 51 (2) ◽  
pp. 219-222
Author(s):  
Jiangrong Chen ◽  
Chunchao Zhu ◽  
Chaojie Wang ◽  
Xiaodan Zhang ◽  
Jian Ni ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mouse Model ◽  
Intestinal Metaplasia ◽  
Infected Mouse ◽  
Genetic Characterization ◽  
Helicobacter Felis

scholarly journals Trefoil Factor Family in Pre-neoplastic Lesions and Gastric Cancer

2018 ◽  
Vol 4 ◽  
Author(s):  
Zahra Behrooznia ◽  
Pouya Ghaderi ◽  
Narges Jafarzadeh ◽  
Azra Izanloo ◽  
Sepideh Mansoori Majoofardi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastrointestinal Tract ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Chronic Atrophic Gastritis ◽  
Suppressor Activity ◽  
Neoplastic Lesions ◽  
Tumor Suppressor Activity ◽  
Trefoil Factor Family

Gastric cancer is the fourth most common cancer and the second leading cause of cancer death worldwide. Although the global incidence of gastric cancer has been decreased dramatically in recent decades, north and northwest of Iran have the highest incidence rate of gastric cancer. Whilst the surgical procedures for gastric cancer have been improved, there is no cure for that. The intestinal type of GC results from pre-neoplastic conditions including atrophic gastritis, intestinal metaplasia and dysplasia. Trefoil Factors Family proteins (TFFs) are small and stable molecules secreted by the mammalian gastrointestinal tract. TFFs constitute a family of three peptides (TFF1, TFF2and TFF3) that are widely expressed in a tissue specific manner in the gastrointestinal tract. Variable TFFs expression in gastric cancer and pre-neoplastic lesions has been found. TFF1 has a tumor suppressor activity and inhibits tumorogenesis in gastric cancer. Its expression decreases in gastritis, gastric atrophy, dysplasia, intestinal metaplasia and gastric cancer.TFF2 has a protective effect on gastrointestinal epithelium. As a prognostic factor, TFF2 expression decreases in gastric ulcer, chronic atrophic gastritis and gastric cancer. TFF3 is considered as an oncogenic factor in gastric tissues. Whilst the normal gastric tissues don’t express TFF3, it increases in intestinal metaplasia. Therefore, more studies are necessary to clarify the role of TFFs in GC and pre-neoplastic conditions. This review has focused on elucidating the important role of TFFs in gastric cancer and pre-neoplastic lesions.

Көркөм тексттеги диалогдун табияты

2019 ◽  
pp. 51-54
Author(s):  
А.М. Токтосунова
Keyword(s):  
Literary Text ◽  
Conversational Speech ◽  
The World ◽  
The Difference

Аннотация. Макалада көркөм тексттеги диалогдун табияты жана аткарган кызматы жөнүндө сөз болот. Мисалдагы диалогдор Ч.Айтматовдун, Т.Касымбековдун чыгармаларынан алынып, талдоо жүргүзүлдү. Диалогдук кептин көркөм чыгармадагы орду жана оозеки кептеги диалогдон айырмачылыгы жөнүндө маалымат берилди. Диалог каармандардын деңгэлин, социалдык, моралдык, психологиялык, интеллектуалдык өзгөчөлүктөрүн, коомдогу социалдык-психологиялык кырдаалды ар тараптуу туюндурушу тууралуу сөз козголот. Ошону менен бирге диалогдун автордук идеяга, анын тажрыйбасына, чеберчилигине, дүйнө таанымына, чыгармачылык деңгээлине байланыштуу макалада белгиленди. Диалог аркылуу образ түзүү, дүйнөнү образдуу чагылдырылып берилери мисалдар менен бекемделди. Б.Усубалиевдин, Т.С.Маразыковдун пикирлери жетекчиликке алынды. Түйүндүү сөздөр: диалог, коммуникация, коннотация, стиль, семантика, функционалдык стиль, эстетика, прагматика, образ, подтексттик информация. Аннотация. В этой статье рассматриваются природа диалога и его роли в художественном тексте. Анализ приведен на примерах произведений Ч. Айтматова и Т. Касымбекова. Дана информация места диалога в художественных произведениях и устной речи, и различия от устной речи. В статье речь идёт о роли диалога в социально-психологической, моральной, интеллектуальной характеристике героев в различных социально-психологических ситуациях. В статье отмечается, что диалог связан с идеями, опытом, мировоззрением, уровнем творческого мастерства автора. Приведены примеры того, что через диалог создаются образы, даётся образная картина мира в различных условиях и ситуациях в художественной литературе. Взяты за руководство мнения Б.Усубалиева и Т. Маразыкова. Ключевые слова: диалог, коммуникация, коннотация, стиль, семантика, функциональный стиль, эстетика, прагматика, образ, подтекстная информация. Annotation. In the article the speech is going about the nature of dialogue and the literary text. The dialogues on examples are from Ch. Aitmatov᾿s and T. Kasymbekov᾿s works and they were analysed. It has been informed about the difference the role of dialogue in creative works and conversational speech. The article deals with the role of dialogue in the socio-psychological, moral, intellectual characterization of the characters in various socio-psychological situations. The article notes that the dialogue is connected with the ideas, experience, worldview, level of the creative skill of the author. Examples are given that images are created through dialogue, an imaginative picture of the world is given in various conditions and situations in fiction.The article has been guided by the opinions of T. Marazykov and B. Usubaliev. Keyword: dialogue, communication, connotation, style, semantics, functional style, aesthetics, pragmatics, image, subtext information.

Surveillance Strategy of Atrophic Gastritis and Intestinal Metaplasia in a Country with a High Prevalence of Gastric Cancer

2011 ◽  
Vol 57 (3) ◽  
pp. 746-752 ◽  
Author(s):  
Woon Geon Shin ◽  
◽  
Heung Up Kim ◽  
Ho June Song ◽  
Su Jin Hong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Surveillance Strategy ◽  
High Prevalence

scholarly journals Clinical Recommendations of Russian Gastroenterological Association and RENDO Endoscopic Society on Diagnosis and Treatment of Gastritis and Duodenitis

2021 ◽  
Vol 31 (4) ◽  
pp. 70-99
Author(s):  
V. T. Ivashkin ◽  
I. V. Maev ◽  
T. L. Lapina ◽  
E. D. Fedorov ◽  
A. A. Sheptulin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Chronic Gastritis ◽  
Eradication Therapy ◽  
Targeted Biopsy ◽  
High Quality ◽  
Familial History ◽  
History Of ◽  
H Pylori

Aim. The clinical guidelines are intended to supplement specialty decision-making for improved aid quality in patients with gastritis and duodenitis though acknowledging the latest clinical evidence and principles of evidencebased medicine.Key points. Gastritis is an inflammatory disease of stomach mucosa, with a separate definition of acute and chronic gastritis. Chronic gastritis is a cohort of chronic diseases uniting a typical morphology of persistent inflammatory infiltration, impaired cellular renewal with emergent intestinal metaplasia, atrophy and epithelial dysplasia of gastric mucosa. Oesophagogastroduodenoscopy (OGDS) or high-resolution OGDS with magnified or non-magnified virtual chromoendoscopy, including targeted biopsy for atrophy and intestinal metaplasia grading and neoplasia detection, are recommended to verify gastritis and duodenitis, precancer states and/or gastric mucosal changes. All chronic gastritis patients positive for H. рylori should undergo eradication therapy as aetiological and subsidiary for gastric cancer prevention. Chronic gastritis patients with symptoms of dyspepsia (epigastric pain, burning and congestion, early satiety), also combined with functional dyspepsia, are recommended proton pump inhibitors, prokinetics, rebamipide and bismuth tripotassium dicitrate in symptomatic treatment. With focal restricted intestinal metaplasia, follow-up is not required in most cases, mainly when advanced atrophic gastritis is ruled out in high-quality endoscopy with biopsy. However, a familial history of gastric cancer, incomplete intestinal metaplasia and persistent H. pylori infection render endoscopy monitoring with chromoendoscopy and targeted biopsy desirable once in three years. Patients with advanced atrophic gastritis should have high-quality endoscopy every 3 years, and once in 1–2 years if complicated with a familial history of gastric cancer.Conclusion. The recommendations condense current knowledge on the aetiology and pathogenesis of gastritis and duodenitis, as well as laboratory and instrumental diagnostic techniques, main approaches to aetiological H. pylori eradication and treatment of dyspeptic states.

Evaluation of the Applicability and Usefulness of the Latin American Guide for Psychiatric Diagnosis, Revised Version, in Comparison with other International Systems among Latin American Psychiatrists

2019 ◽  
Vol 7 (4) ◽  
Author(s):  
Javier Esteban Saavedra
Keyword(s):  
Diagnostic Accuracy ◽  
Latin American ◽  
Psychiatric Diagnosis ◽  
Diagnostic System ◽  
Clinical Situation ◽  
Classification Systems ◽  
Evaluation Instrument ◽  
Dsm 5 ◽  
The World ◽  
Icd 10

Background: The Latin American Guide to Psychiatric Diagnosis, Revised Version (GLADP-VR) represents an adaptation of the ICD-10 that seeks through a biopsychosocial approach to better reflect the holistic framework and culture of Latin American countries. This revision of the original GLADP included updated Latin American annotations and a new integrated diagnostic model centered on the person. Objectives: The aim of this study was to evaluate among Latin American psychiatrists the levels of applicability and usefulness of the GLADP-VR in comparison with major international diagnostic classification systems. Method: The survey evaluation instrument included questions about fundamental characteristics of a useful diagnostic guide and comparative questions about the acceptability and usefulness of the GLADP-VR, the original ICD-10, DSM-IV and DSM-5, and suggestions to improve the guide. The sample included 127 Latin American psychiatrists with an interest on Diagnosis and Classification and membership in one of the 17 national psychiatric societies affiliated with Latin American Psychiatric Association (APAL). They were sent the evaluation instrument by e-mail. Thirty-seven (29.1%) responses were obtained. There were no indications of demographic bias among respondents and no-respondents.The vast majority of respondents answered the questionnaire completely. Ninety-two percent reported knowing the GLADP-VR before the survey and 65.6% had actually used it before.Results: The most commonly used diagnostic system was the original ICD-10 (86.5%), followed by the GLADP-VR (56.8%). Regarding applicability, the diagnostic system recognized as the most user-friendly was the ICD-10 followed by the GLADP-VR, with the most difficult being the DSM-5. Concerning diagnostic accuracy, the GLADP-VR was found most useful; and the DSM-5 was least useful. Regarding usefulness for clinical care and professional practice, the ICD-10 was rated highest, followed by the GLADP-VR, and lowest was DSM-5. The least valued in this regard was the DSM-5. Regarding usefulness for yielding a complete view of the clinical situation, the GLADP-VR was best (83.3%), and DSM-5 was the lowest. Concerning cultural and psychosocial contextualization, the GLADP-VR was considered most useful, well above ICD-10 and the DSMs. Furthermore, the GLADP-VR was considered more useful for teaching and research by about 80% of psychiatrists, superior to the other diagnostic systems.Discussion: The findings of this study on the most prevalent use of ICD-10 are consistent with the results of a survey conducted earlier by the World Psychiatric Association across the world. In addition, in the present study less than half of the respondents used regularly the DSMs. The findings of the present study concerning the GLADP-VR were quite consistent with the corresponding findings of an earlier preliminary evaluation of the GLADP-VR. This seems to be related to the GLADP-VR comprehensive personalized diagnostic formulation with various components, including narratives. Conclusions: There are indications that the GLADP-VR is seen in Latin America as having higher diagnostic accuracy, yielding a comprehensive view of the clinical situation and its context, and more suitable for teaching, research, and work in community mental health.

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