Serum Selenium Levels in Glaucoma: a Pilot Study

2021 ◽  
Author(s):  
Marianna Lucio ◽  
Alexander Fick ◽  
Bernhard Michalke ◽  
Robert Laemmer ◽  
Sami Hosari ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Open Angle Glaucoma ◽  
Study Groups ◽  
Gender Effects ◽  
Total Serum ◽  
Serum Selenium ◽  
Serum Samples ◽  
Age And Gender ◽  
Inductively Coupled ◽  
And Gender

Abstract Background Trace elements are assumed to be involved in glaucoma pathogenesis via changes in oxidative stress. Especially serum selenium (Se) has been linked to this neurodegenerative disease. Serum Se levels differ between countries due to nutrition and ethnicity. It was the aim of the present study to investigate serum Se levels in primary open-angle glaucoma (POAG) patients and controls in Germany and to consider potential age and gender effects. Material and Methods The Se concentration of 39 serum samples (22 patients with POAG, 17 controls) were analyzed by inductively coupled plasma-sector field mass spectrometry (ICP-sf-MS) in high resolution mode. Covariance and percentile regression were analyzed. Age and gender were defined as confounding factors and their different trends were investigated. Moreover, age was examined across different quantiles of Se levels. Results Total serum least-squares means (LS-means) Se levels were 132.02 µg/L (controls) and 134.86 µg/L (POAG). Total serum Se levels did not differ between the study groups (p > 0.05). Significant age and gender effects of serum Se were observed. Quantile analysis showed that the 1st serum Se quantile decreased with increasing age in POAG patients in contrast to controls. The odds ratios of the 1st serum Se were 1.3 (with 2nd quantile) and 1.3 (with 3rd quantile), respectively. Conclusion The serum Se level of the German cohort was almost half of those of the published US cohort (glaucoma 209.11 ng/mL; control 194.45 ng/mL). Age and gender effects were observed; the serum Se level increased with age in women (controls and POAG), however, Se levels decreased with age in men (controls and POAG).

Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy

2010 ◽  
Vol 3 ◽  
pp. PRI.S6145
Author(s):  
A.J. Russo ◽  
Robert deVito
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Zinc Levels ◽  
Hepatocyte Growth ◽  
Post Therapy

Aim To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels. Subjects and methods Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls ( P = 0.18) were tested for HGF concentration using ELISAs, and tested for copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with schizophrenia, before zinc and B-6 therapy, were significantly lower than age and gender similar controls ( P = 0.016), and significantly lower in schizophrenia patients pre-therapy compared to post therapy ( P = 0.028). HGF levels normalized (reached levels similar to controls) post-therapy. Zinc levels in these same individuals also normalized, and perceived symptoms, particularly anxiety ( P = 0.03), improved significantly after therapy. Discussion These results suggest an association between low HGF levels and schizophrenia and demonstrate that zinc and B-6 therapy may be associated with the normalization of HGF levels and perceived improvement in symptoms.

scholarly journals Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Bipolar Disorder Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5528 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Serum Concentration ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Zinc Levels ◽  
Bipolar Patients

Aim To assess serum HGF concentration in individuals with bipolar disorder and investigate the efficacy of zinc therapy on these levels. Subjects and Methods Serum from 35 individuals diagnosed with bipolar disorder and 19 age and gender similar controls were tested for HGF concentration using ELISAs, and copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with bipolar disorder were significantly lower than age and gender similar controls ( P = 0.0021). HGF serum concentration was significantly lower in Bipolar patients pre-therapy ( P = 0.0009) and HGF levels normalized post-therapy. Zinc levels in these same individuals also normalized ( P = 0.0046) and patient's perceived severity of Bipolar symptoms significantly decreased after therapy ( P = 0.0003). We also found a significant direct correlation between Zinc and HGF serum concentration in the bipolar patients ( P = 0.04). Discussion These results suggest an association between low HGF levels and bipolar disorder and also demonstrate that zinc therapy may be associated with the normalization of HGF levels and decrease in severity of disease.

scholarly journals Analysis of eight nutrient elements in peripheral blood of children and adolescents using inductively coupled plasma‐mass spectrometry

2021 ◽  
Author(s):  
Fang Luan ◽  
Bin Liu ◽  
Shuzhen Sun ◽  
Yuan Chen ◽  
Yanqiu Xu ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Whole Blood ◽  
Inductively Coupled Plasma ◽  
Age Groups ◽  
Reference Intervals ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
And Gender

Abstract Background Several researches have been conducted on the associations between elements and diseases. Few studies have examined trace elements in young people’s hair. The objective of this study is to investigate the influence of age, gender and season on the contents of magnesium (Mg), calcium (Ca), Iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), selenium (Se) and strontium (Sr) as well as to establish the reference intervals (RIs). Methods We conducted a retrospective study of 589 apparently healthy children and adolescents under 19 years old. Quantitative analysis has been carried out using inductively coupled plasma-mass spectrometry (ICP-MS). Eight nutrient elements in peripheral blood of children and adolescents in eastern China were grouped according to age, sex or season, and analyzed using and Mann-Whitney U test and spearman statistical analyses. RIs were defined by using 95% confidence interval. Results Precisions of ICP-MS detecting for Mg, Ca, Fe, Cu, Zn, Mn, Se and Sr are 2.8%~12.2%. The linearity were all > 0.999 and the bias were all within 10%. Differences between contents of particularly Mg, Fe, Cu and Zn in girls’ and boys’ whole blood were found, and higher contents of Mg, Cu for boys were measured in some age groups. Positive correlations for Fe, Zn, Se and Sr, while negative for Ca and Cu were found with age. And substantial differences between age groups were stated. In general, an increasing trend was found for bioelements (Fe, Zn,Se) both for girls and boys in all age groups, while for Ca and Cu changes were even decreasing for children and teenagers. The most frequently correlating element pairs were Fe-Zn, Mg-Se, and Fe-Se in five successive age groups. Lower contents of essential elements (Mg, Ca, Fe, Zn, Se) were found in summer comparing with other seasons. Finally, the reference interval of each element was initially established according to age and gender grouping. Conclusions The contents of elements in whole blood varies depending mainly on the gender and age of children and adolescents. Besides, season is also a factor that affects the contents of elements in the body. The reference intervals of elements in whole blood grouped by age and gender provide a reference basis for clinical diagnosis and treatment of element-related diseases.

A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels

2020 ◽  
Author(s):  
Luciana Albuquerque ◽  
Catarina Oliveira ◽  
António Teixeira ◽  
Pedro Sa-Couto ◽  
Daniela Figueiredo
Keyword(s):  
Comprehensive Analysis ◽  
Gender Effects ◽  
Age And Gender ◽  
European Portuguese ◽  
And Gender

Age and gender effects on quantitative sudomotor axon reflex testing and application to idiopathic pure sudomotor failure

2010 ◽  
Vol 158 (1-2) ◽  
pp. 137
Author(s):  
Kimiko Yoshimaru ◽  
Yoshihiko Nakazato ◽  
Naotoshi Tamura ◽  
Nobuo Araki
Keyword(s):  
Gender Effects ◽  
Age And Gender ◽  
Axon Reflex ◽  
Reflex Testing ◽  
And Gender

scholarly journals Biophysical properties of the human finger for touch comprehension: influences of ageing and gender

2017 ◽  
Vol 4 (8) ◽  
pp. 170321 ◽  
Author(s):  
A. Abdouni ◽  
M. Djaghloul ◽  
C. Thieulin ◽  
R. Vargiolu ◽  
C.  Pailler-Mattei ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Adhesive Force ◽  
Arithmetic Mean ◽  
Tactile Perception ◽  
Gender Effects ◽  
Biophysical Properties ◽  
Age And Gender ◽  
Positive Correlation ◽  
And Gender ◽  
Human Finger

The human finger plays an extremely important role in tactile perception, but little is known about how age and gender affect its biophysical properties and their role in tactile perception. We combined studies on contact characteristics, mechanical properties and surface topography to understand age and gender effects on the human finger. The values obtained regarding contact characteristics (i.e. adhesive force) were significantly higher for women than for men. As for mechanical properties (i.e. Young's modulus E ), a significant and positive correlation with age was observed and found to be higher for women. A positive correlation was observed between age and the arithmetic mean of surface roughness for men. However, an inverse age effect was highlighted for women. The age and gender effects obtained have never been reported previously in the literature. These results open new perspectives for understanding the weakening of tactile perception across ages and how it differs between men and women.

Age and gender effects in the cultural life script of Japanese adults

2014 ◽  
Vol 26 (3) ◽  
pp. 307-321 ◽  
Author(s):  
Steve M. J. Janssen ◽  
Ai Uemiya ◽  
Makiko Naka
Keyword(s):  
Gender Effects ◽  
Age And Gender ◽  
Cultural Life ◽  
Japanese Adults ◽  
And Gender ◽  
Life Script
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